Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study was carried out to investigate the neurotoxic and immunotoxic effects of
Indole-3-butyric acid
(
IBA
), a plant growth regulator (PGR), on rats at subacute and subchronic exposure. The neurotoxic effects of
IBA
were evaluated by measuring the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Biomarkers selected for immunotoxic monitoring were the activities of
adenosine deaminase
(
ADA
) and myeloperoxidase (MPO) in various tissues of rats exposed to 25 and 50 ppm dosages of
IBA
for 20 and 45 days. Results showed that the administrations of
IBA
decreased AChE and BChE activities in some tissues of the rats treated with both dosages and periods of
IBA
. With regard to the immunotoxic effects,
ADA
activity significantly decreased whereas MPO activity increased after subacute and subchronic exposure with both dosages in most of the tissues of rats compared with controls. The observations presented led us to conclude that the administrations of
IBA
at subacute and subchronic exposure decreased AChE, BChE and
ADA
activities whereas increased MPO activity in various tissues of rats. This may reflect the potential role of these parameters as useful biomarkers for toxicity of
IBA
.
...
PMID:Neurotoxic and immunotoxic effects of Indole-3-butyric acid on rats at subacute and subchronic exposure. 1944 22
