Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neurons of the tuberomammillary nucleus (TM) in the rat have previously been shown to contain the enzymes
adenosine deaminase
(
ADA
), histidine decarboxylase (HDC) and
glutamate decarboxylase
(
GAD
). Some neurons coextensive with this cell group also exhibit immunoreactivity for the neuropeptide galanin, express monoamine oxidase activity (MAO), or display the ability to accumulate and decarboxylate 5-hydroxytryptophan (5-HTP). Histochemical and immunohistochemical techniques were used to determine the extent to which these neurochemical properties are colocalized in neurons immunoreactive for
adenosine deaminase
. Galanin was found to coexist with
ADA
in about 45% of the neurons in the TM. In addition, a large number of cells immunoreactive for galanin alone were observed in the posterior hypothalamus outside the confines of TM. Neurons displaying MAO activity formed a subpopulation of those immunoreactive for
ADA
; all neurons containing MAO also contained
ADA
whereas only 60% of the
ADA
-immunoreactive cells were reactive for MAO. Approximately 20% of
ADA
-immunoreactive neurons represented nearly all cells having 5-HTP uptake capability. However, a very few cells in TM showing 5-HTP uptake capability appeared to be devoid of
ADA
immunoreactivity. These results demonstrate that although neurons of TM are homogeneous with respect to a number of possible neurotransmitters markers and associated enzymes, these neurons are heterogeneous with respect to their expression of galanin, MAO and 5-HTP uptake. In certain respects the segregation of histochemical properties within TM correlates with previous histochemical work by others, and suggests the possibility of functional diversity of TM.
...
PMID:Neuronal colocalization of adenosine deaminase, monoamine oxidase, galanin and 5-hydroxytryptophan uptake in the tuberomammillary nucleus of the rat. 242 41
