Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The transmural distribution of the adenosine metabolizing enzyme activities 5'nucleotidase (5'N) and
adenosine deaminase
(
ADA
) across the left ventricular wall was explored in rats with heart hypertrophy induced by aortocaval shunt (
FAC
), or coarctation of the abdominal aorta (S) or by tireotoxicosis (T).
FAC
caused largest heart hypertrophy with a very short latency (1 day: + 0%, 3.5 days: + 30%, 7 days: + 41%, 21 days: + 49%). A 30% increase in the left ventricle free wall was observed after 3.5, 14 or 28 days of treatment with
FAC
, T or S respectively. Different changes in enzyme levels and alteration of transmural distribution profiles were observed with the different types of heart hypertrophy. Level of 5'N was decreased with
FAC
, did not change with T and increased with S; levels of
ADA
were always increased. The pattern of the transmural distribution of 5'N was affected by S but not by T and
FAC
, whereas distribution of
ADA
was not affected by S and T and was altered by
FAC
transiently.
...
PMID:[The enzymatic activity of adenosine metabolism in the rat heart. The effects of cardiac hypertrophy]. 129 73
