Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.5.4.4 (adenosine deaminase)
 5,136 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

About 280 unrelated individuals living in the province of Bologna (Northern Italy) have been studied for the following red cell enzymatic markers: phosphoglucomutase (PGM), adenylate kinase (AK), adenosine deaminase (ADA) and phosphohexose isomerase (PHI). 116 subjects from the same sample have also been analysed for red cell acid phosphatase (ACP). The observed gene frequencies are PGM21 = 0.280; AK2 = 0.030; ADA2 = 0.091; ACPa = 0.297; ACPb = 0.647; ACPc = 0.056. In the PHI system two individuals with the variant PHI 3-1 phenotype have been found.
 ...
PMID:An analysis of red cell enzymatic markers in the province of Bologna (Italy). 19 53

A series of Chinese hamster cell lines commonly used in somatic cell genetics research was examined for variations in either expression or electrophoretic mobility of 43 enzyme gene products by starch gel electrophoresis followed by histochemical staining. Stable variations in the qualitative expressions of the creatine kinase B and adenylate kinase 1 (AK1) loci were detected among the cell lines and verified in subclones. All ten cell lines examined were deficient in the expression of the lactate dehydrogenase B locus. Polymorphisms were detected for the adenosine deaminase (ADA) and AK2 loci among the cell lines and shown to exist in a series of Chinese hamsters. Electrophoretic banding patterns from tissues, sublines, and subclones of the same genetic source and Hardy-Weinberg distribution of phenotypes from different genetic sources confirmed that the polymorphisms were based on its inheritance of two codominant autosomal ADA and AK2 alleles that specified electrophoretically variant enzymes.
 ...
PMID:Genetic polymorphisms and gene expression variations at enzyme loci in chinese hamster cell lines. 719 2