Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Immune checkpoint inhibitors (ICIs) are promising drugs for various cancers. However, immune activation by ICIs can lead to immune-related adverse events (irAEs).
Autoimmune encephalitis
is a rare irAE, and its clinical features remain unknown. We herein report two patients with ICI-associated autoimmune encephalitis who, saliently, showed elevated
adenosine deaminase
(
ADA
) levels in the cerebrospinal fluid (CSF). This is the first report of increased
ADA
levels in the CSF of patients with ICI-induced autoimmune encephalitis. Although the mechanism of the
ADA
increase is poorly understood, elevated
ADA
in the CSF may be informative in the diagnosis of this rare disorder.
...
PMID:Elevated Adenosine Deaminase Levels in the Cerebrospinal Fluid in Immune Checkpoint Inhibitor-induced Autoimmune Encephalitis. 3124 6
