Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.4 (
adenosine deaminase
)
5,136
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The paper summarizes the results of studies of the activity of
adenosine deaminase
(
ADA
) in biological fluids (including that during tuberculin tests) as a tool for the differential diagnosis of different forms of extrapulmonary tuberculosis, such as pleuritis,
synovitis
, meningitis, tuberculosis of female genitals and peripheral lymph nodes, and uveitis. The threshold for the activity of
ADA
or the magnitude of its increase in antigenic stimulation, which provides the optimum ratio of the sensitivity to specificity of the tests and their maximum diagnostic efficiency, are given. The optimization of diagnosis of tuberculous
synovitis
is shown to facilitate the study of
ADA
activity concomitantly with the determination of the level of antituberculosis antibodies. The tests under discussion are economically sound and yield results in several hours and, in case of a provocative test, in 3 days.
...
PMID:[Adenosine deaminase in the complex diagnosis of different forms of extrapulmonary tuberculosis]. 1719 84
