Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.4.17 (
adenosine deaminase
)
5,206
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The activity expression and corticosterone inhibition of
adenosine deaminase
(
ADA
) were studied in the spleen, stomach, and liver of mice at various postnatal ages. The specific activity of
ADA
is very low in the spleen and stomach of 5- and 10-day-old mice, and increases significantly (2.5- to 3.0-fold) in 20- and 30-day-old animals. Its level shows a further increase in the spleen of 60-day-old mice while stomach increase of
ADA
is not significant. In contrast, the activity of
ADA
is significantly higher in the liver of 5- and 10-day-old mice, decreases markedly (2.5-fold) in 20- and 30-day-old animals and shows a sharp increase in the liver of 60-day-old mice.
Corticosterone
administration brings a marked inhibition in the activity of
ADA
at all ages studied in the spleen and stomach whereas it inhibits the liver
ADA
only at 30 and 60 days postnatal age. These findings suggest an age- and tissue-specific expression of
ADA
activity and also indicate corticosterone as an inhibitory regulator of this enzyme.
...
PMID:Developmental expression and corticosterone inhibition of adenosine deaminase activity in different tissues of mice. 756 66
