Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.5.1.52 (PNGase F)
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Human Gene/Protein
chromosome 2 open reading frame 7 14.3
N-glycanase 13.7
PNG1 13.6
hPAP21 13.3
Retinal pigment epithelium-specific protein 13.3
C19orf24 13.3
tyrosinase precursor 13.3
SID1 transmembrane family, member 2 12.8
NGLY1 12.6
B3GNT8 12.3
LPHA 12.3
lysozyme precursor 12.3
Acid carboxypeptidase 11.9
hCLCA4 11.8
Na+/H+ exchanger isoform NHE-3 11.8
HUT11 11.4
SLC4A8 11.2
PGDS protein 11.2
Endo-beta-N-acetylglucosaminidase 11.1
glucosaminyl 11.0
SDS protein 10.9
SAKS1 10.9
B4GALNT3 10.8
FR-beta 10.8
Hyal-3 10.6
PAP-2a 10.6
neighbor of BRCA1 gene 1 10.6
GLUT11 10.6
Fbs1 10.6
PUB 10.6
Maltase-glucoamylase 10.5
B4GALNT2 10.5
MANB 10.4
NXN 10.3
B4-2 10.3
GP55 10.3
Man9-mannosidase 10.3
endo-beta-N-acetylglucosaminidase 10.2
LW blood group 10.2
skin tryptase 10.1
CSS3 10.1
ERIC-1 10.0
basic proline-rich protein 10.0
B3GNT2 9.9
sodium-dependent organic anion transporter 9.9
SPC1 9.9
RhD protein 9.8
SLC4A10 9.8
H3P 9.8
DDI1 9.8
beta4Gal-T1 9.7
Glucosidase I 9.7
MGAT3 9.6
MGAT5 9.6
O-sialoglycoprotein endopeptidase 9.6
COL8A2 9.6
alpha 1,2-mannosidase 9.5
LacCer synthase 9.5
hSBP 9.5
EC-SOD 9.5
telencephalin 9.5
ALG2 9.4
SVEP1 9.4
osteoinductive factor 9.4
ST6GAL1 9.3
Butyrophilin 9.3
sodium-dependent vitamin C transporter 2 9.3
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9.3
PMP22 protein 9.3
B transferase 9.2
BST-1 9.2
CD9P-1 9.2
DM9 9.2
Coagulation factor V 9.2
LRG 9.2
cyclophilin C 9.2
N-acetylglucosaminyltransferase II 9.2
KLKB1 9.1
TCF11 9.1
STF-1 9.1
more...
Disease
Carbohydrate-deficient glycoprotein syndrome 9.8
Feline Leukemia 9.4
FAIDS 9.4
X-linked ocular albinism 8.7
JMS 7.7
fucosidosis 7.6
CLN5 7.4
EL2 7.4
mixed gliomas 7.4
toxic nodular goiter 7.1
Aspartylglucosaminuria 6.9
LQT2 6.8
hereditary fructose intolerance 6.7
pineoblastoma 6.6
Pfeiffer 6.6
STL 6.5
diffuse goiter 6.3
SDS 6.3
sialidosis 6.3
HMS 6.2
East Coast fever 6.1
metastatic osteosarcoma 5.9
FDC 5.9
corneal dystrophy 5.9
hyperviscosity syndrome 5.8
monocytic leukemia 5.8
mannosidosis 5.8
Papilloma 5.6
gangliosidosis 5.6
uterine sarcoma 5.5
AAA 5.4
neuronal ceroid lipofuscinosis 5.3
Classical swine fever 5.3
congenital disorder 5.2
Ovary 5.2
NMS 5.1
Farber 5.0
MPS I 5.0
LCA 5.0
Hurler 5.0
Angiostrongylus cantonensis 4.9
Gerstmann 4.9
Tic 4.9
RMD 4.9
Schistosoma japonicum 4.8
ADCC 4.8
lysosomal storage disease 4.8
IPS 4.8
autoimmune thyroid disease 4.8
prostatic disease 4.7
galactosemia 4.7
CLN3 4.7
CEM 4.6
MSA 4.6
avian sarcoma 4.6
NS2 4.6
brain disorder 4.6
hyperosmolality 4.5
NMS 4.5
MEC 4.5
cervical adenocarcinoma 4.5
Ovary 4.5
HPC 4.5
Fraser 4.4
renal tubular acidosis 4.4
HES 4.3
PHA 4.3
Wiskott-Aldrich syndrome 4.2
HOS 4.2
Moore 4.2
epididymis 4.1
bovine leukemia 4.1
long QT syndrome 4.1
primitive neuroectodermal tumor 4.0
papilloma 4.0
choriocarcinoma 3.9
abdominal aortic aneurysm 3.9
Rous sarcoma 3.8
vaccinia 3.8
primitive neuroectodermal tumor 3.7
more...
Symptom
HSA 2.8
cachexia 1.9
Ill 0.9
thinning 0.9
starvation 0.7
collapse 0.5
seizures -0.4
diarrhea -1.5
Drug
1-Deoxynojirimycin 8.7
Batroxobin 8.4
Ceftibuten 8.0
Swainsonine 8.0
Ancrod 7.7
Asn 7.6
Estracyt 7.5
Estracyt 7.3
GNA 7.3
Pronase 7.0
Darbepoetin alfa 7.0
Bromelain 6.9
NAG 6.4
Epoetin 6.3
Papain 6.2
NovoSeven 6.1
Monensin 6.0
Enrofloxacin 5.9
Flunitrazepam 5.9
beta-Galactosidase 5.6
MEA 5.6
Gel 5.5
Hyaluronidase 5.5
Maltose 5.5
Hyaluronidase 5.4
Thyroglobulin 5.4
Galactose 5.3
Iloprost 5.3
ABC 5.2
TES 5.2
Urokinase 5.1
Campath 4.8
Campath 4.8
BoNT/A 4.6
DFP 4.5
Cetuximab 4.4
ADR 4.3
Infliximab 4.2
Infliximab 4.2
Herceptin 4.2
RFP 4.1
DPA 4.0
CTA 3.9
Gelatin 3.6
Bevacizumab 3.6
Glucagon 3.5
uPA 3.3
G418 3.2
ETA 2.9
Rituximab 2.9
CaCl2 2.7
CaCl2 2.7
CaCl2 2.7
lactose 2.6
Retinoic acid 2.6
MRC 2.6
THF 2.4
DNase I 2.3
Leaf 2.3
Angiotensin II 2.0
CAM 1.8
Bifidobacterium 1.8
CSF 1.8
NH3 1.6
IL-2 1.5
EE2 1.4
lysine 1.3
ENT 1.3
IFN-gamma 0.5
MAP 0.4
NADH -0.1
Dermatol -2.1
Enzyme
PNGase F 14.3
okinaxobin II 13.3
endomannosidase 10.9
aminopeptidase W 10.9
Rmd 10.5
endo-beta-galactosidase 10.5
endoglycosidase H 10.4
endo-beta-galactosidase 10.2
endo-alpha-N-acetylgalactosaminidase 10.2
deuterolysin 9.8
mannosidase I 9.5
N-acetylglucosaminyltransferase II 9.4
glycoprotease 9.4
stem bromelain 9.2
GPI-PLD 9.1
mannosylphosphoryldolichol synthase 9.1
endo-N 8.8
N-acetylglucosaminyltransferase I 8.7
chymotrypsin C 8.7
beta-1,4-galactosyltransferase 8.6
aspartylglucosaminidase 8.6
GalT 8.5
alpha-mannosidase 8.5
chondroitinase B 8.4
alpha-L-fucosidase 8.4
alpha-L-fucosidase 8.2
galactosyltransferase I 8.2
alpha-L-fucosidase 8.1
leishmanolysin 8.1
carboxyl proteinase 8.1
endoproteinase Asp-N 8.1
mannosidase II 8.1
alpha-N-acetylgalactosaminidase 8.0
GPI-specific phospholipase C 8.0
neuraminidase 7.8
polypeptide N-acetylgalactosaminyltransferase 7.8
glucosidase II 7.8
sialidase 7.8
endoproteinase Glu-C 7.6
ancrod 7.5
alpha-N-acetylglucosaminidase 7.5
deaminase 7.4
chondroitinase 7.3
N-acetylgalactosaminidase 7.3
galactanase 7.2
chondroitinase 7.2
H,K-ATPase 7.1
lichenase 7.1
lactase-phlorizin hydrolase 7.0
N-acetylglucosaminyltransferase V 7.0
pyroglutamate aminopeptidase 7.0
N-acetylglucosaminyltransferase 7.0
chondroitin ABC lyase 6.9
alpha-L-iduronidase 6.8
cathepsin C 6.7
lactase-phlorizin hydrolase 6.7
sialyltransferase 6.6
sialyltransferase 6.6
sialyltransferase 6.6
lysyl endopeptidase 6.4
alcohol oxidase 6.4
ribonuclease 6.4
ribonuclease 6.4
galactose oxidase 6.3
conjugase 6.2
arylsulfatase A 6.1
chondroitinase AC 6.1
heparinase 6.0
ceramidase 6.0
bromelain 5.9
ficin 5.9
phosphomannose isomerase 5.9
hyaluronidase 5.8
legumain 5.7
biotinidase 5.7
carboxypeptidase E 5.7
lecithin:cholesterol acyltransferase 5.7
tissue kallikrein 5.6
trypsin 5.6
carboxypeptidase Y 5.6
more...
Compound
N-Benzoyl-L-tyrosine ethyl ester 13.3
N-Acetyl-L-tyrosine 11.3
Neu4,5Ac2 10.9
2-AB 10.7
Ac-Tyr-OEt 10.5
2-aminobenzamide 10.5
2-AA 10.1
2-aminobenzoic acid 9.9
2-aminobenzoic acid 9.9
LNFP I 9.8
trifluoromethanesulfonic acid 9.8
trifluoromethanesulfonic acid 9.7
Sedoheptulose 9.7
palmitamide 9.6
Phenamil 9.2
Castanospermine 9.1
Tunicamycin 8.8
N-Hydroxysuccinimide 8.7
Zwittergent 3-14 8.4
asparagine 8.3
Benzamidine 8.2
GlcNAc 8.1
Ceftibuten 8.1
3-aminobenzoic acid 7.9
KDN 7.9
N-Acetylglucosamine 7.8
Estramustine 7.8
GDP-L-fucose 7.7
Swainsonine 7.7
GalNAc 7.6
Stains-all 7.6
iduronate 7.5
Rabeprazole 7.5
2-ethylhexanoic acid 7.4
Neu5Ac 7.4
Remazol Brilliant Blue R 7.3
TRU 7.3
keratan sulfate 7.2
Saxitoxin 7.2
DDM 7.2
Mannose 7.1
BPL 7.0
Estracyt 7.0
Estracyt 7.0
3'-AMP 6.9
Fucose 6.8
Lewis X 6.7
UDP-galactose 6.6
Brefeldin A 6.6
Brefeldin A 6.6
Sialic acid 6.5
nitrous acid 6.5
CH3-THF 6.5
BBM 6.5
SOA 6.4
galactose 6.4
DMM 6.3
SDS 6.3
PAG 6.3
Dermatan sulfate 6.2
Glu-Glu 6.2
TOF 6.2
DDM 6.2
HMS 6.2
phenyl acetate 6.1
N-acetyl-D-glucosamine 6.1
Monensin 6.1
Thiabendazole 6.1
Chondroitin 6.0
Cystine 5.9
CMP 5.9
Rhodopsin 5.9
PNA 5.9
TBT 5.8
CMP 5.7
propionamide 5.7
propionamide 5.7
TES 5.7
NH4OH 5.6
Cystine 5.6
more...