Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.52 (
PNGase F
)
1,527
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
CD22
and CD21 are glycoproteins primarily expressed on normal and neoplastic human B cells. The surface expression of these two molecules parallel each other during normal B cell differentiation, and the reported relative mobilities for
CD22
and CD21 are 130/140 kDa and 140 kDa, respectively. Herein we present a detailed analysis of the biosynthesis and structure of
CD22
and also compare it directly to CD21. Electrophoresis under reducing and nonreducing conditions suggested that
CD22
and CD21 may have similarities in intra-chain disulfide bond formation. Biosynthesis and processing of
CD22
and CD21 were very similar with respect to kinetics and post-translational modification, and both could be phosphorylated. However, endoglycosidase digestion (using
N-glycanase
and endoglycosidase H) and peptide mapping (using V8 protease and N-chlorosuccinimide) strongly suggested that
CD22
and CD21 are distinct gene products.
...
PMID:Structural characterization of the human B lymphocyte-restricted differentiation antigen CD22. Comparison with CD21 (complement receptor type 2/Epstein-Barr virus receptor). 296 6
