Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.5 (
urease
)
7,257
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Three mononuclear Cu(II) complexes Cu(HL
1
)Cl
2
(1), Cu(HL
2
)Cl
2
(2), and Cu(L
3
)
SCN
(3) have been synthesized based on chelating hydrazone ligands HL
1
, HL
2
, and HL
3
, respectively. These new compounds gave satisfactory IR-spectroscopic data and were further characterized by elemental and X-ray diffraction analyses. Their
urease
inhibitory evaluation was tested in vitro against jack bean
urease
. The results showed that the inhibitory activities of the copper complexes are all superior to the positive reference. Enzyme kinetics studies were undertaken to estimate the inhibition mechanism of the copper complexes. Molecular docking simulations have been performed to rationalize their binding models. In addition, their interactions with serum albumin were also studied.
...
PMID:Preparations, characterization, and biological features of mononuclear Cu(II) complexes based on hydrazone ligands. 2763 93
