Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.5.1.4 (deaminase)
 5,113 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors observed changes in activity of leucine amino-peptidase (E.C. 3.4.1.1--LAP), gamma-glutamyl transpeptidase (F.C 2.3.2.2--GGTP) and Co++-activated acylase in blood serum of patients with ovarian carcinoma, with or without ascites, treated with Ledakrin (1-nitro-9-[3-dimethylaminopropylamino] acridine). It was stated that the activities of LAP and GGTP increased during the treatment and during tumor progression. The level of Co++-activated acylase increased only slightly during the treatment and therefore, the determination of this enzyme appeared to be of no use in monitoring the therapy of ovarian carcinoma.
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PMID:Blood serum peptidases in patients with ovarian carcinoma treated with Ledakrin. 1 75

Co++-activated acylase activity was studied in the blood serum and liver homogenates from rabbits poisoned with CCl4 in doses of 0-5 g/kg body weight intraperitoneally. Activity of this enzyme in serum increased on the first day after poisoning, but the rise was of short duration. Increased serum activity of the enzyme was accompanied by an increase in acylase activity in liver homogenates, which persisted to the ninth day, i.e. to the end of the observation period, when serum acylase activity returned to normal. Co++-activated acylase activity in serum was not correlated with its activity in liver homogenates. Co++-activated acylase activity was significantly correlated with AlAT and GGTP activities, but acylase and LAP were not correlated.
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PMID:Cobalt-activated acylase activity in experimental toxic liver damage. 2 21