Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.12 (
biotinidase
)
392
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
DL-ethionine increases the activity of liver
biotinidase
, an enzyme which hydrolyzes biotinylesters and biotinylpeptides. Chronic DL-ethionine feeding increases transiently the activity of
biotinidase
in mouse and rat liver, after which it remains elevated in the serum. In the present work we show that both isomers of DL-ethionine are equally good enhancers of the liver
biotinidase
, while, 3-ethylthiopropionate, the toxic metabolite of DL-ethionine, has no effect on the
biotinidase
activity of either liver or serum. We have also employed two different combinations of inhibitors of the hydrolytic pathway of
SAH
, a transmethylation product and potent inhibitor of methylation. It was found that these inhibitors (EHNA and Ara-A, 2-deoxycoformycin and adenosine) increase the activity of serum
biotinidase
as was the case with ethionine. Because
SAH
does not ethylate biomolecules, these changes in
biotinidase
activity, which can not be prevented by adenine, biotin or lecithin are most probably related to the inhibition of methylation.
...
PMID:Enhancement of biotinidase activity in mouse serum by inhibitors of methylation. 349 18
