Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.12 (
biotinidase
)
392
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Biotinidase shows two binding sites for biotin, with Kd = 59 and 3 nM respectively, and requires
tryptophan
and cysteine residues of the
biotinidase
protein for biotin-binding activity. Analysis of human serum by various column-chromatographic techniques indicates that
biotinidase
is the only protein which exchanges with labelled (+)-biotin. It was shown previously that epileptic patients receiving a high average dose of anticonvulsants (containing a carbamide group) have lower biotin concentrations than those receiving a low dose. We have shown in human serum and with purified
biotinidase
that these anticonvulsant drugs compete with biotin for binding to the protein moiety.
...
PMID:Role of human serum biotinidase as biotin-binding protein. 322 2
