Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.1 (
asparaginase
)
2,695
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Acute Myeloid Leukemia (AML), a cancer of the myeloid line of blood cells, progresses rapidly and is typically fatal within weeks or months if left untreated. Asparaginases are a class of enzymatic anti-leukemia agents that induce apoptosis in leukemia cell lines; however, the role of
L-asparaginase
in the induction of apoptosis in AML cells has not been investigated. In this study, we investigated the apoptosis-inducing effect of
L-asparaginase
and its underlying mechanism in AML U937 cells. The results showed that
L-asparaginase
significantly inhibited the proliferation of U937 cells by inducing apoptosis. Furthermore, the low baseline expression level of
asparaginase
synthase (ASNS) demonstrated the sensitivity of U937 cells and AML M5, a rare subtype of AML, to
L-asparaginase
. Apoptosis induced by
L-asparaginase
is mediated by
apoptosis-inducing factor
(
AIF
). Our findings show the potential of
L-asparaginase
as an effective approach in treating AML via the induction of apoptosis mediated by
AIF
.
...
PMID:L-asparaginase induces in AML U937 cells apoptosis via an AIF-mediated mechanism. 2438 99
