Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.5.1.1 (asparaginase)
 2,695 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antineoplastic properties of different Schiff bases obtained by the interaction of 5-nitrofuran with substituted pyrimidines have been examined both in vitro and in vivo. In vitro studies on L 5178Y/asparaginase sensitive, HL 60 and P 388 cell lines and in vivo studies on the P 388 cell line indicate that all the compounds are potential antineoplastic agents. However, 2-(5-nitro-2-furfurylidene-amino)-pyrimidine (SBP1) is the most effective, and 2-(5-nitro-2-furfurylidene-amino)-6-hydroxypyrimidine (SBP3) is the least effective agent. Doubling time, rates of protein and DNA synthesis inhibition and LD50 values-1,000 mg/kg body weight for SBP1 and 1,275 mg/kg body weight for 2-(5-nitro-2-furfurylidene-amino)-4- methylpyrimidine (SBP2)- in the oral route support the activity and use of SBP1 and SBP2 as future anticancer agents.
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PMID:Studies on the antineoplasticity of Schiff bases containing 5-nitrofuran and pyrimidine. 221