Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.1 (
asparaginase
)
2,695
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Asparaginase of Escherichia coli obtained according to the previously developed scheme (extraction, acidification, heating with ammonium sulphate, twice repeated precipitation with ethanol and DEAE-cellulose chromatography) was examined by the methods of polyacrylamide gel electrophoresis, isoelectric focusing and molecular weight assay. Asparaginase activity was measured by the Nessler method. With respect to the above characteristics, the
asparaginase
preparation was very similar to those described in the literature, e.g. Krasnitin (
FRG
) and Leunase (Japan).
...
PMID:[Characteristics of asparaginase from Escherichia coli at different stages of purification]. 80 Feb 57
Glutamine(asparagine)ase from Ps. boreopolis 526 has an antineoplastic effect on lymphoid leukemia P-388. The enzyme half-life in the mouse serum is 8.5 hours. Glutamine(asparagine)ase has no cross-antigenicity with
L-asparaginase
from E. coli (Bayer,
FRG
). Specific antibodies against
L-asparaginase
(Bayer,
FRG
) do not influence the activity of glutamine(asparagine)ase.
...
PMID:[Biological properties of glutamin-(asparagin-)ase from Pseudomonas boreopolis 526]. 373 May 98
Preparations of
L-asparaginase
made in the USSR,
FRG
and Japan were studied comparatively in 277 patients with acute lymphoblastic leukemia and lymphosarcomas. It was shown that the clinical characteristics of the preparation made in the USSR and the preparation (crasnitin) made in the
FRG
were identical. By the antileukemic action the preparation made in the USSR was superior to the preparation (
leunase
) made in Japan in the treatment of adult patients with such hemoblastosis forms. The effect of the three drugs in the treatment of children was analogous. The nature of the side effects of the three drugs was the same. However, their level was different. The allergenic effect of
leunase
on the patients was the most pronounced. L-Asparaginase made in the USSR and crasnitin are recommended for wide use in clinical practice.
...
PMID:[Comparative evaluation of the clinical effectiveness of 3 preparations of E. coli L-asparaginase]. 638 31
