Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.5.1.1 (asparaginase)
 2,695 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In experiments with mongrel male rats the asparaginase and adenosine deaminase activities in the liver tissue and adenosine deaminase in blood serum were determined under different conditions of parenteral nutrition. The intraperitoneal administration of the preparations of parenteral nitrogen nutrition-aminosol and amikin (0.25 g of conditioned protein per 100 g of body weight) against a background of protein deficiency and exhaustion is shown to cause no changes as compared to the control of these enzymes activity in the liver tissue and blood serum. The asparaginase activity in the liver increases noticeably with the dose of aminosol and amikin up to 0.5 g of conditioned protein per 100 g of body weight and the adenosine deaminase activity undergo no essential changes. A statistically significant decrease in the adenosine deaminase activity is observed only under administration of aminosol against a background of protein deficiency. Under oral feeding of rats with amikin in the composition of protein-free (0.5 g of conditioned protein per 100 g of body weight), as distinct from its parenteral administration, the asparaginase activity in the liver is considerably lower. The adenosine deaminase activity in the liver and blood serum is not practically changed. A part of the nitrogen excreted from the organism with urea and ammonia under protein deficiency is supposed to be a product of deamination of endogenic purine and pyrimidine derivatives.
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PMID:[Dynamics of asparaginase and adenosine deaminase activity in the liver with intraperitoneal administration of aminosol and amikin preparations of parenteral nitrogen nutrition]. 680 84

The activities of asparaginase and adenosine desaminase were determined in the liver tissue and that of adenosine desaminase--in blood serum of rats under different conditions of protein and protein-free diet. The asparaginase activity is shown to decrease significantly in the liver tissue under conditions of protein-free diet and increases under long complete protein and complete caloric diet as well as under complete fasting. The adenosine desaminase activity in the liver tissue lowers significantly as compared to the control under conditions of both the 20-day complete protein diet and protein diet and increases to some extent as compared to its level in the animals under conditions of protein deficiency and complete fasting. In blood serum the adenosine desaminase activity decreases under the 20-day complete protein diet and when transferring rats from the 10-day protein-free diet to the 10-day complete protein diet. It is supposed that the unidirectional change in the adenosine desaminase activity in the liver tissue under different conditions of feeding is associated with the diversity of ways stimulating the production of adenosine in the decomposition processes.
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PMID:[Asparaginase and adenosine deaminase activities in rat liver under different conditions of protein and protein-free diet]. 721 Feb 7