Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.1 (
asparaginase
)
2,695
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report a girl with type II
Ehlers-Danlos syndrome
who developed acute lymphoblastic leukemia. At the age of 5 years, she was referred to our hospital with mild hyperelasticity of skin and mild joint hypermobility, 'cigarette paper' wrinkled scarring of the forehead, and moderate ecchymoses. She was diagnosed with type II
Ehlers-Danlos syndrome
(mitis type). Ten months after referral, she developed acute lymphoblastic leukemia (FAB classification; L1). Her leukemia cells expressed both CD 10 and HLA-DR antigens. We treated her with
L-asparaginase
, prednisolone, vincristine, doxorubicin, methotrexate, and cytosine arabinoside and she has remained disease-free for 6 years since the first remission. To our knowledge, this is the first report of
Ehlers-Danlos syndrome
in a patient who developed acute lymphoblastic leukemia.
...
PMID:Acute lymphoblastic leukemia in Ehlers-Danlos syndrome. 892 93
