Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.5.1.1 (
asparaginase
)
2,695
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The antitumour activity of the preparations of
L-asparaginase
from E. coli and Erw. carotovora with respect to lymphadenosis L-5178 and Yorker's
carcinosarcoma
(ascitic cariants) has been established. No difference in antitumour efficacy of the preparation of
L-asparaginase
obtained from E. coli and Erw. carotovora was noted.
...
PMID:[Results of an experimental study of the antitumor activity of 1-asparaginase from E. coli and Erw. carotovora]. 32 Sep 35
Cisplatinum given intravenously (i.v.), hydroxyurea given orally (os), procarbazine (os) and
L-asparaginase
(i.v.), on a decreasing scale, produce significant (p less than 0.01) adrenocortical activation over 4-h period at a single dose per kg 10 times higher than those employed in human therapy. Only hydroxyurea retained this activity after a 5-day treatment both in normal and Walker
carcinosarcoma
-bearing rats. Adrenocortical activation depends on the presence of pituitary ACTH both after single or repeated treatments.
...
PMID:Tolerance to pituitary-adrenal axis activation by anticancer drugs in normal and tumour-bearing rats. 659 30
