Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:3.4.25.1 (proteasome)
28,817 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein proteasome 26143 ubiquitin 11111 Mol 3420 proteasome inhibitor 2336 Sep 1729 endoplasmic reticulum 1706 MCP 1571 p53 1145 Ubiquitin 1094 ATP 1042 Proteasome 1039 E3 ubiquitin ligase 994 ubiquitin ligase 974 ATPase 767 chymotrypsin-like 711 cytokine 551 caspase-3 521 insulin 492 SCF 479 MHC class I 466 polypeptide 416 mTOR 408 Bcl-2 397 peptidase 379 p21 367 calpain 341 interferon 319 threonine 306 histone 299 p27 297 F-box protein 291 tumor necrosis factor 290 LMP7 286 p62 279 MAPK 277 cyclin 274 fused 274 major histocompatibility complex 271 histone deacetylase 268 SDS 268 muscle protein 267 p97 255 Pseudomonas 254 IFN 251 MHC 250 phosphatase 236 p38 236 TNF 235 AKT 232 alpha-synuclein 232 CD8 230 LMP2 230 interacting protein 227 AAA 224 ERK 221 atrogin-1 217 HSP70 216 LC3 215 Hsp90 211 tyrosine kinase 205 cullin 201 PI3K 201 Skp1 197 deubiquitinating enzyme 195 p65 192 cyclin D1 189 heat shock protein 187 IL-6 186 synuclein 184 JNK 183 VCP 182 COP9 182 MDM2 181 lipopolysaccharide 181 cytochrome c 178 APC 178 NMR 177 membrane protein 176 catenin 175 CD46 170 more...

Disease cancer 4327 tumor 2451 multiple myeloma 1373 Parkinson's disease 831 Alzheimer's disease 713 breast cancer 606 tumorigenesis 483 leukemia 427 muscular atrophy 398 tumor growth 390 HIV 335 hepatocellular carcinoma 315 amyotrophic lateral sclerosis 291 diabetes 285 prostate cancer 279 Huntington's disease 272 carcinogenesis 271 SDS 269 carcinoma 255 virus infection 251 lymphoma 237 lung cancer 232 abdominal aortic aneurysm 228 melanoma 227 neuroblastoma 225 AAA 224 tumor progression 214 MCF 189 APC 183 immunodeficiency 172 dementia 171 ischemia 170 cold 165 colon cancer 162 mantle cell lymphoma 155 Hippel 154 colorectal cancer 153 adenocarcinoma 147 heart failure 147 cytomegalovirus 142 sepsis 137 hematologic malignancies 132 sepsis 131 cystic fibrosis 130 retinoblastoma 127 acute myeloid leukemia 121 ovarian cancer 119 atherosclerosis 118 wasting 114 glioma 111 parkinsonism 110 influenza 110 Mycobacterium 110 hypertension 109 obesity 109 tuberculosis 99 pancreatic cancer 99 glioblastoma 99 Epstein 98 rheumatoid arthritis 97 cervical cancer 94 infectious diseases 92 acute promyelocytic leukemia 92 peripheral neuropathy 91 non-small cell lung cancer 91 metastases 90 herpes simplex 88 squamous cell carcinoma 87 hepatitis B 86 GSH 84 type 2 diabetes 84 stroke 84 myopathy 84 ATM 83 renal cell carcinoma 82 gastric cancer 81 anemia 81 Leukemia 80 Hodgkin's disease 80 lung carcinoma 78 more...

Symptom starvation 257 cachexia 171 ataxia 96 pain 88 weakness 83 collapse 50 fatigue 44 diarrhea 33 seizures 32 anorexia 28 tremor 26 vomiting 18 exhaustion 17 agitation 16 nausea 15 functional recovery 15 acidity 15 respiratory distress 14 erythema 12 dystonia 12 headache 11 bradykinesia 10 acute stress 9 hyperoxia 9 memory loss 9 hypotonia 9 hypothermia 9 cerebellar ataxia 8 anesthesia 8 dyspnea 8 nausea and vomiting 7 arthralgia 7 discomfort 6 overweight 6 bone pain 6 thinning 5 asthenia 5 myalgia 5 numbness 5 discomfort 5 constipation 4 splenomegaly 4 autodigestion 4 dizziness 4 incoordination 4 skin damage 3 decreased appetite 3 hypercapnia 3 cough 3 angina 3 analgesia 3 hepatomegaly 3 HSA 3 joint stiffness 3 sleepiness 3 chills 2 lethargy 2 chest pain 2 general problem 2 Tenderness 2 twitching 2 stigma 2 tingling 2 paresis 2 spasticity 2 loss of balance 2 paresthesia 2 male subfertility 2 bitter taste 2 Halo 2 back pain 2 myoclonus 2 Scratch 1 sneezing 1 ENT 1 oliguria 1 limb pain 1 adenitis 1 apathy 1 spasm 1 more...

Drug lysine 610 Bortezomib 544 Parkin 155 Parkin 155 IFN-gamma 154 ROS 134 Cardiovasc 67 AMC 56 CSF 45 IL-2 43 Dermatol 40 MAP 38 Asn 36 ascorbate 31 Gel 29 Leaf 23 NADH 23 vitamin E 21 Lenalidomide 19 Ethanol 17 Arsenic trioxide 17 Angiotensin II 16 ABC 16 caffeine 16 DFP 16 ICI 15 G-CSF 15 CAM 14 Kenyan 14 Alanine 14 Nitric Oxide 13 Rituximab 13 CaCl2 13 CaCl2 13 CaCl2 13 Adriamycin 13 NVP 13 citric acid 12 ETS 11 Imatinib 11 IFN-beta 11 Dial 11 TAT 10 lactose 10 Sorafenib 10 Herceptin 9 Glycerol 9 MRC 9 CoCl2 9 BH4 9 Etoposide 9 CoCl2 9 TAK 9 Capsicum 8 Vorinostat 8 ATV 8 Monit 8 p75 8 ROC 8 Heme 8 Biopolymers 8 Mutagen 8 Taxol 8 GEO 8 CTX 7 Gefitinib 7 DNase I 7 Amiloride 7 ALA 7 RFP 7 ADM 7 PCP 7 Fulvestrant 7 Retinoic acid 7 Troglitazone 6 HCH 6 ADR 6 Gleevec 6 BoNT/A 6 Lovastatin 6 more...

Enzyme proteasome 28817 protein kinase 855 mitogen-activated protein kinase 848 ATPase 793 trypsin 503 ERK 437 caspase-3 424 focal adhesion kinase 208 APC 202 luciferase 201 protein kinase C 199 ubiquitin-protein ligase 188 cdc2 188 MEK 177 IKK 175 RNA polymerase 168 chymotrypsin 161 calcineurin 142 elastase 138 PARP 135 superoxide dismutase 132 glutathione S-transferase 130 ornithine decarboxylase 123 caspase-8 123 AMP-activated protein kinase 109 cathepsin B 105 isopeptidase 101 ACS 96 catalase 94 GSK 94 phosphatidylinositol 3-kinase 92 caspase-9 89 subtilisin 89 AMPK 88 RNase 78 RNase 74 topoisomerase 71 AMPK 67 topoisomerase 67 peroxidase 61 alkaline phosphatase 58 cathepsin D 58 m-calpain 56 complex I 55 lysozyme 53 MIP 53 caspase-1 51 reverse transcriptase 50 tyrosine hydroxylase 50 CD10 50 prolyl hydroxylase 49 tyrosinase 47 lactate dehydrogenase 47 protein phosphatase 2A 46 TPP 45 chaperonin 43 beta-galactosidase 41 PNGase F 41 endonuclease 39 ATP synthase 39 NQO1 38 NO synthase 38 phosphoinositide 3-kinase 38 papain 37 ClpP 36 glyceraldehyde-3-phosphate dehydrogenase 36 MAP 35 P-glycoprotein 35 lipase 34 cathepsin L 33 glyceraldehyde-3-phosphate dehydrogenase 33 NADPH oxidase 32 creatine kinase 30 glutathione peroxidase 30 NADPH oxidase 30 p100 30 glyceraldehyde-3-phosphate dehydrogenase 30 ACE 30 kinesin 29 glyceraldehyde-3-phosphate dehydrogenase 29 more...

Compound DNA 2529 Dec 1986 MCP 1571 ATP 1042 oxygen 960 lysine 803 serine 639 Ubiquitin 619 tyrosine 539 calcium 507 Clin 492 leucine 481 glucose 471 threonine 464 cysteine 432 alanine 386 arginine 323 SDS 278 sodium 274 water 273 TNF 235 AAA 224 nitrogen 213 iron 199 nitric oxide 195 hydrogen 194 zinc 190 aldehyde 187 phosphate 187 methionine 184 Phe 183 aldehyde 172 cAMP 162 proline 151 salt 151 sulfate 146 MDA 146 His 144 Asp 141 glutamate 141 copper 140 acetate 128 glutamine 128 CHIP 127 Ile 125 retinoic acid 122 TAP 121 ethanol 120 MEK 115 boron 110 urea 106 Insulin 104 ammonium 103 Gly 101 galactose 99 TOF 99 COS 97 ACS 96 ACS 96 H2O2 94 GSH 88 GSH 88 MTT 85 ADP 79 N-acetylcysteine 78 ADP 74 NH2 74 GTP 74 ADP 74 glycerol 71 Cardiol 70 cadmium 70 AMP 69 Ethylene 66 Cbl 64 DEAE 62 NAD 62 tryptophan 61 potassium 58 vinyl 56 more...

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