Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.25.1 (
proteasome
)
28,817
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
DUG
gene of Drosophila encodes a putative ATPase that is a structural and functional homolog of the yeast SUG1 product. When introduced into S. cerevisiae, the Drosophila
DUG
gene rescued the lethality associated with a SUG1 mutant. Anti-
DUG
antibodies recognized a protein that migrated in high molecular weight complexes, along with components of the 26S
proteasome
, and also immunoprecipitated components of the 26S
proteasome
from embryonic extracts. Proteins recognized by the affinity-purified antibody raised against
DUG
were localized in either a punctate cytoplasmic distribution or in the nucleus, depending on the cell type, consistent with the subcellular localization of the 26S
proteasome
in various cell types.
...
PMID:The DUG gene of Drosophila melanogaster encodes a structural and functional homolog of the S. cerevisiae SUG1 predicted ATPase associated with the 26S proteasome. 946 29
