Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.25.1 (
proteasome
)
28,817
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To investigate the effectiveness of high oral doses of the antiemetic agent 4-amino-5-chloro-N-(2-diethyl-aminoethyl)-
2-methoxybenzamide
(metoclopramide,
MCP
, Gastrosil) against nausea and vomiting induced by certain cyostatic drugs, blood was withdrawn repeatedly from 9 patients;
MCP
plasma levels were then determined. Patients received 3 X 50 mg
MCP
-hydrochloride tablets in intervals of 4 h. Plasma levels determined from 7 patients were as follows: 173 ng/ml 1 h following the first dose of
MCP
235 ng/ml 1 h following the second dose and finally 265 ng/ml following the third dose. Using the oral
MCP
dosage regimen presented in this study, high and relatively constant
MCP
plasma concentrations without undesired peak levels could be achieved.
...
PMID:[Metoclopramide plasma levels following oral administration of high doses for prophylaxis of emesis in cytostatic therapy]. 654 37
