Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.25.1 (
proteasome
)
28,817
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies have shown an association between coiled-coil domain-containing (CCDC) genes and different cancers. Our previous studies revealed that
CCDC43
is highly expressed in colorectal cancer, but the expression and molecular mechanisms of
CCDC43
in gastric cancer (GC) are yet to be determined. Here, we show that
CCDC43
is overexpressed in gastric tissues.
CCDC43
expression is closely related to tumor differentiation, lymph-node-metastasis, and prognosis of gastric cancer. Overexpression of
CCDC43
promotes the proliferation, invasion, and metastasis of GC cells.
CCDC43
may upregulate and stabilize ADRM1, resulting in the construction of the ubiquitin-mediated
proteasome
. In contrast, inhibition of ADRM1 could reverse the function of
CCDC43
in GC both in vitro and in vivo. Our data demonstrate that transcription factor YY1 directly binds to
CCDC43
and ADRM1 gene promoters, leading to over-expression of
CCDC43
and ADRM1. Furthermore, in vitro experiments demonstrate that knock down of
CCDC43
or ADRM1 attenuates the YY1-mediated malignant phenotypes. Finally, the association among YY1,
CCDC43
and ADRM1 is validated in clinical samples. Our findings suggest that the
CCDC43
-ADRM1 axis regulated by YY1, promotes proliferation and metastasis of GC, and the axis may be a potential therapeutic target for GC.
...
PMID:The CCDC43-ADRM1 axis regulated by YY1, promotes proliferation and metastasis of gastric cancer. 3227 16
