Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.25.1 (proteasome)
 28,817 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prevalence of back and joint complaints and of rheumatoid arthritis (RA), chondrocalcinosis (CC) and osteoarthritis (OA) was studied in three representative population subsamples aged 70, 75 and 79 years. The prevalence of back pain was 38% and of joint complaints 40%, both significantly higher in females. The prevalence of RA was not significantly different between the age groups. Chondrocalcinosis increased with age in females. Radiographic and clinical OA of knees was less prevalent with increasing age. Symptoms of wrist and finger OA occurred in 1-4% of females but not males. Enlargement of DIP joints occurred in 50% of females and 25% males. Radiographic OA of first MCP joints was more prevalent with age in males but not females. Obesity correlated with radiographic OA of knees in females. Clinical and radiographic OA of fingers and knees did not correlate with previous strenuous occupations.
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PMID:Joint disorders at ages 70, 75 and 79 years--a cross-sectional comparison. 294 52

The SAPHO syndrome represents a variety of clinically similar disorders with the key features of hyperostotic bone lesions in combination with chronic pustular skin disease. The respective pathophysiology of bone and joint manifestations in SAPHO syndrome is still a matter of discussion. For example it does not appear to represent reactive arthritis and HLA B27 antigen, with the latter being typically present in patients with spondyloarthopathies. Treatment of SAPHO syndrome is also not well established and consists of various antiinflammatory and antirheumatic drugs. Here, we report a female patient with active SAPHO syndrome suffering from sternal swelling of unknown origin that had been known for 10 years and a 4-year-history of severe lower back pain. Remarkable were also a typical pustulous palmar erythema associated with swelling and decreased motility of both MCP-I joints. Inflammation parameters were high with an ESR 68 mm/1st hour and a CRP of 19.6 mg/l. She was initially treated with rofecoxib and doxycycline, followed by sulfasalazine with only partial clinical response. Thereafter, both articular symptoms as well as cutaneous lesions responded well to a combination therapy with methotrexate and sulfasalazine. Thus, the case illustrates nicely that methotrexate in combination with another DMARD can be successfully applied to patients with long-term active SAPHO syndrome.
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PMID:Sequential Combination Therapy Leading to Sustained Remission in a Patient with SAPHO Syndrome. 1947 1