Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.B1 (angiotensin-converting enzyme 2)
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Human Gene/Protein
angiotensin-converting enzyme 2 14.3
COVA1 13.9
netrin G1 12.9
transmembrane protease, serine 2 12.9
SARS protein 12.3
adducin 1 12.1
SLC6A19 11.8
collectrin 11.5
UTS2 11.3
sodium-dependent neutral amino acid transporter 11.3
RAB1A 11.2
transmembrane protease, serine 4 11.2
SLC6A20 11.2
SLC6A18 11.1
vasoactive intestinal peptide receptor 2 11.1
B(0)AT1 11.0
SOC3 11.0
PRCP 10.9
MRGPRD 10.9
S protein 10.9
paternally expressed gene 1 10.8
TMPRSS2 10.5
vascular endothelial growth factor D 10.5
ACE2 10.5
SOX14 10.4
APLN 10.3
SARS 10.3
ENPEP 10.2
SIT1 10.2
CAPG 10.2
Rev-erb alpha 9.9
sirtuin 6 9.9
airway trypsin-like protease 9.8
cytoskeleton-associated protein 4 9.8
RAC2 9.6
HAT1 9.6
angiotensin II type 2 receptor 9.6
XT2 9.6
KDM5B 9.6
orphan transporter 9.5
Activated leukocyte cell adhesion molecule 9.3
SLC34A3 9.3
SBP1 9.2
SLC36A1 9.1
AT1R 9.1
AGTR1 8.9
SLC15A1 8.8
K26 8.8
EIF2 8.8
JARID1B 8.8
CTSL 8.7
AGTR2 8.7
SP-10 8.6
RNASEL 8.6
Na(+)/H(+) exchanger 3 8.5
renin receptor 8.5
neutral amino acid transporter 8.5
abc 8.5
prolylcarboxypeptidase 8.4
AT1B 8.4
Surfactant protein B 8.4
FOXJ1 8.4
ACE 8.3
AT3 8.3
BSG 8.2
SLC7A7 8.2
LGR4 8.1
zinc metallopeptidase 8.1
G protein-coupled receptor 30 8.0
SFRP5 8.0
CD147 8.0
TRIB3 8.0
DCAF1 8.0
apelin 8.0
ADAM17 7.9
apelin receptor 7.9
Ang II 7.9
ADD1 7.8
BST2 7.8
TNF-alpha converting enzyme 7.8
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Disease
Kidney replacement 12.1
SLC34A3, 11.5
glycinuria 10.9
HND 10.9
influenza-like disease 10.2
SARS 10.2
Cytokine storm 10.0
Coronavirus infection 9.2
BK virus nephropathy 8.4
AT3 8.3
AT3 8.3
AT3 8.3
AT3 8.3
AT3 8.3
AT3 8.3
AT3 8.3
AT3 8.3
AT3 8.3
neurogenic hypertension 8.1
MODY3 7.9
viral pneumonia 7.4
aminoaciduria 7.2
emerging infectious disease 7.2
Acute infection 7.1
EMC 6.9
intestinal tuberculosis 6.7
hypertensive nephropathy 6.6
gastrointestinal infection 6.6
Inflammatory Bowel Disease 6.3
Alport syndrome 6.2
MAS 6.2
STEMI 6.1
white coat hypertension 6.1
myocarditis 5.9
respiratory disease 5.9
paralytic ileus 5.7
ATM 5.6
atypical pneumonia 5.6
virus infection 5.5
lymphopenia 5.5
acute tubular necrosis 5.4
PCT 5.2
Guillain-Barre syndrome 5.2
coagulopathy 5.1
acute myocarditis 5.1
cardiovascular disease 5.0
Ludwig 4.9
NPC 4.9
diabetic nephropathy 4.8
adult respiratory distress syndrome 4.8
sialadenitis 4.8
SRS 4.7
hypertension 4.7
respiratory failure 4.6
stomatitis 4.6
Hereditary angioedema 4.5
Pulmonary arterial hypertension 4.5
emotional stress 4.5
pneumonia 4.4
ARF 4.4
interstitial pneumonia 4.3
gallbladder cancer 4.3
Chronic kidney disease (CKD) 4.3
trypanosomiasis 4.3
Proteinuria 4.2
diabetic cardiomyopathy 4.2
Tag 4.2
hypernatremia 4.2
systolic hypertension 4.2
porphyria cutanea tarda 4.2
respiratory infection 4.2
disseminated intravascular coagulation 4.2
Syndrome 4.1
silicosis 4.1
essential hypertension 4.1
infectious diseases 4.1
Endothelial dysfunction 4.1
heart failure 4.0
atherosclerotic cardiovascular disease 4.0
immunopathology 4.0
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Symptom
loss of taste 9.0
cardiovascular impairment 8.2
anosmia 7.8
Gastrointestinal symptoms 6.7
respiratory distress 6.5
cough 4.8
shortness of breath 4.6
myalgia 4.6
polyuria 4.3
despair 4.3
dizziness 4.0
polydipsia 3.8
acute stress 3.8
tachypnea 3.6
anorexia 3.5
diarrhea 3.3
vomiting 3.1
cerebellar ataxia 3.1
cyanosis 3.0
nausea 3.0
dyspnea 3.0
paresthesia 2.6
fatigue 2.6
thinning 2.5
headache 2.3
abdominal pain 2.3
flushing 2.3
arthralgia 2.1
ataxia 2.0
constipation 1.6
Ill 1.5
weakness 1.3
chest pain 0.8
seizures 0.6
overweight 0.2
pain -0.8
anesthesia -1.8
Drug
Pemirolast 11.6
Z-Pro-Prolinal 11.2
Ambroxol hydrochloride 10.8
Bisolvon 10.2
Ebastine 9.0
Mepolizumab 8.6
Olmesartan 8.2
Angiotensin II 7.2
Mycophenolic acid 6.5
Liraglutide 6.2
Ramipril 6.2
Valsartan 6.0
Emodin 6.0
Papain 5.8
Emodin 5.7
Azithromycin 5.7
Oseltamivir 5.7
Rosiglitazone 5.3
Aprotinin 5.1
Isoniazid 5.0
CTC 4.9
Doxycycline 4.8
Captopril 4.8
CTC 4.6
Alanine 4.5
Glycyrrhiza 4.5
GEO 4.3
Amiloride 4.1
Fructose 4.0
Paraffin 3.8
Silica 3.7
Ringer's solution 3.5
Heme 3.3
Glutathione 2.5
CAM 2.4
ROS 2.3
IL-2 2.1
ROC 2.0
Cardiovasc 1.8
Asn 1.4
Nephron 1.4
Asthma 1.3
IFN-gamma 1.1
CSF 1.0
MAP 1.0
Nephron 0.8
lysine 0.7
caffeine 0.5
ascorbate 0.4
Dial 0.0
Monit -0.2
Enzyme
angiotensin-converting enzyme 2 14.9
A-transferase 10.0
quercetinase 9.8
renin 7.7
ACE 7.3
furin 7.3
acetylesterase 7.2
aminopeptidase A 7.2
cathepsin L 6.3
chymase 5.5
AGT 5.3
prolyl endopeptidase 5.3
TACE 5.3
m-calpain 5.3
transcriptase 5.2
CD13 5.1
CD10 5.0
bromelain 4.9
thymidine phosphorylase 4.9
flavin-containing monooxygenase 4.8
heparinase 4.6
NADPH oxidase 4.5
indoleamine 2,3-dioxygenase 4.4
NADPH oxidase 4.4
kallikrein 4.4
PRA 4.2
thermolysin 4.0
heme oxygenase 3.9
MMP 3.9
glutamate decarboxylase 3.8
subtilisin 3.8
soluble epoxide hydrolase 3.8
RNase H 3.5
firefly luciferase 3.5
glucokinase 3.4
acetyl-CoA carboxylase 3.4
NQO1 3.3
isocitrate dehydrogenase 3.3
caspase-1 3.3
AMPK 3.3
papain 3.2
aldose reductase 3.2
isocitrate dehydrogenase 3.2
PCP 3.0
cathepsin D 2.9
cdc2 2.9
cathepsin B 2.9
CPT 2.8
mitogen-activated protein kinase 2.7
pyruvate kinase 2.6
glucose oxidase 2.5
demethylase 2.5
ACS 2.5
glyceraldehyde-3-phosphate dehydrogenase 2.5
dihydrofolate reductase 2.4
phosphoinositide 3-kinase 2.4
AMPK 2.3
AMP-activated protein kinase 2.2
RNA polymerase 2.2
MAP 2.1
NO synthase 2.0
thrombin 1.9
pepsin 1.8
caspase-3 1.8
MEK 1.8
glutathione reductase 1.7
ERK 1.7
phosphatidylinositol 3-kinase 1.5
tissue plasminogen activator 1.5
alkaline phosphatase 1.4
luciferase 1.3
thromboplastin 1.2
beta-lactamase 1.2
PARP 1.2
trypsin 1.1
proteasome 1.1
tyrosine hydroxylase 1.1
RNase 0.9
RNase 0.8
collagenase 0.8
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Compound
C14H15N7 14.9
C14H15N7 14.9
C14H15N7 14.9
C14H12N2O3 12.9
C17H16N2O2 11.8
aceturate 9.9
Citronellol 9.5
Withanolide 9.5
Eriodictyol 9.0
Berenil 8.7
Ang II 8.6
Xanthan 8.5
Paricalcitol 8.2
Hydroxychloroquine 8.0
Monocrotaline 7.4
Angiotensin II 7.3
Oridonin 7.2
Lopinavir 7.2
TGR 7.2
EMC 7.1
maslinic acid 6.9
Angiotensin I 6.9
ADMA 6.5
Candesartan 6.3
Oseltamivir 6.3
Ritonavir 6.3
Ribavirin 6.2
4-methylphenyl 6.1
Azithromycin 6.1
APN 6.0
aldosterone 6.0
Emodin 6.0
Baicalin 6.0
Telmisartan 6.0
Sphingosine 1-phosphate 5.9
Losartan 5.4
STZ 5.4
TACE 5.3
benzenesulfonamide 5.2
benzenesulfonamide 5.2
AICAR 5.2
benzenesulfonamide 5.2
Enalapril 5.1
Chloroquine 5.1
Chloroquine 5.1
DPI 5.0
AGE 5.0
Silymarin 5.0
Doxycycline 4.9
Emodin 4.8
Bradykinin 4.8
Hydroxyproline 4.8
PCM 4.7
POP 4.6
acetate 4.6
MES 4.6
MES 4.6
Alanine 4.5
AICAR 4.4
Quercetin 4.3
8-OHdG 4.3
Biotin 4.2
Serine 4.2
Ibuprofen 4.2
serine 4.1
Proline 4.1
BNP 4.1
D-Ala 4.0
DOCA 4.0
MCP 4.0
Fructose 4.0
Piper 3.9
PPI 3.9
Collagen 3.8
Bisphenol A 3.7
Bisphenol A 3.7
Parenteral 3.7
DPP 3.6
Vimentin 3.6
TBI 3.6
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