Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.B1 (
angiotensin-converting enzyme 2
)
1,025
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Vascular and cardiovascular inflammation and thrombosis occur in patients with severe coronavirus disease-2019 (COVID-19). Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, the authors found that: 1) cardiovascular tissues and endothelial cells express putative genes for severe acute respiratory syndrome coronavirus-2 infection, including
angiotensin-converting enzyme 2
(
ACE2
) and basigin (
BSG
); 2) severe acute respiratory syndrome coronavirus-2 receptor pathways
ACE2
/transmembrane serine protease 2 and
BSG
/
peptidylprolyl isomerase B
(A) polarize to lung/epithelium and vessel/endothelium, respectively; 3) expression of host genes is relatively stable with age; and 4) notable exceptions are
ACE2
, which decreases with age in some tissues, and
BSG
, which increases with age in endothelial cells, suggesting that
BSG
expression in the vasculature may explain the heightened risk for severe disease with age.
...
PMID:Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells. 3313 10
