Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.B1 (
angiotensin-converting enzyme 2
)
1,025
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Fibroblast growth factor 21
(
FGF21
) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. However, the role of
FGF21
in hypertension remains elusive. Here we show that
FGF21
deficiency significantly exacerbates angiotensin II-induced hypertension and vascular dysfunction, whereas such negative effects are reversed by replenishment of
FGF21
. Mechanistically,
FGF21
acts on adipocytes and renal cells to promote induction of
angiotensin-converting enzyme 2
(
ACE2
), which in turn converts angiotensin II to angiotensin-(1-7), then inhibits hypertension and reverses vascular damage. In addition,
ACE2
deficiency strikingly abrogates these beneficial effects of
FGF21
in mice, including alleviation of angiotensin II-associated hypertension and vascular damage. Otherwise, pharmaceutical inhibition of angiotensin-(1-7) attenuates the protective effect of
FGF21
on angiotensin II-induced vascular dysfunction, but not on hypertension. Thus,
FGF21
protects against angiotensin II-induced hypertension and vascular impairment by activation of the
ACE2
/angiotensin-(1-7) axis via fine-tuning the multi-organ crosstalk between liver, adipose tissue, kidney, and blood vessels.
...
PMID:FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. 2979 43
