Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.69 (botulinum neurotoxin)
1,901 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SNAP 206
heavy chain 154
Sep 132
SNARE 132
syntaxin 82
Mol 64
membrane protein 59
VAMP 51
metalloprotease 46
N-ethylmaleimide-sensitive factor 31
VAMP-2 29
fused 28
SDS 25
axonal 24
polypeptide 21
insulin 17
substance P 17
SV2 17
mer 17
ATP 17
VAMP2 17
syntaxin 1A 16
strabismus 15
SNAP-23 15
Aplysia 15
synaptotagmin II 14
calcitonin 13
gut 12
cellubrevin 10
SV2C 10
serum albumin 9
VAMP1 9
ADP 9
NSF 9
endoprotease 8
choline acetyltransferase 8
amyloid precursor protein 8
neuraminidase 8
P2' 8
nerve growth factor 7
cytokine 7
TRPV1 7
synaptophysin 7
scFv 7
albumin 6
p47 6
C-terminal peptide 6
neuronal protein 6
peroxidase 6
lectin 6
N-ethylmaleimide-sensitive fusion protein 6
GTP 6
GABA 6
MLD 6
CD1 5
TOF 5
CA1 5
synaptotagmin 2 5
glycoprotein 5
She 5
VAMP7 5
NMR 5
CGRP 5
ANOVA 5
endoplasmic reticulum 5
acetylcholinesterase 5
phospholipase A2 5
amylase 5
MHC 5
proteasome 5
C10 4
C15 4
caspase-3 4
prion 4
SV2A 4
ACS 4
thioredoxin 4
synaptotagmin I 4
Met 4
E-cadherin 4
more...
Disease
tetanus 126
stroke 45
cerebral palsy 45
migraine 35
Parkinson's disease 25
SDS 25
chronic pain 23
anthrax 19
depression 19
incontinence 18
interstitial cystitis 18
dysphagia 17
strabismus 17
neuroblastoma 17
multiple sclerosis 15
cancer 14
prolapse 13
cholera 11
movement disorder 10
BPS 9
cold 8
insulinoma 7
osteoarthritis 7
epilepsy 7
incontinence 7
Overactive bladder 6
dysphonia 6
influenza 6
diabetes 6
trigeminal neuralgia 6
metachromatic leukodystrophy 6
infectious diseases 5
Alzheimer's disease 5
toxemia 5
neurological disease 5
parkinsonism 5
urinary tract infection 5
dysautonomia 5
plaque 5
tumor 4
prostatitis 4
neuropathy 4
status epilepticus 4
amyotrophic lateral sclerosis 4
anal fissure 4
varices 4
carpal tunnel syndrome 4
dementia 4
arthritis 4
LCA 4
diplopia 4
diphtheria 4
diabetic neuropathy 4
Dystonia 4
postherpetic neuralgia 4
plantar fasciitis 4
achalasia 4
Chronic migraine 4
nocturia 4
Evans 4
pheochromocytoma 4
xerostomia 4
temporal lobe epilepsy 3
rabies 3
tennis elbow 3
IVA 3
ischemia 3
respiratory failure 3
Venezuelan equine encephalitis 3
psoriasis 3
carcinoma 3
disinhibition 3
ICD 3
akinesia 3
fits 3
hemiparesis 3
muscular atrophy 3
regional pain syndrome 3
HCC 2
Bladder 2
more...
Symptom
pain 153
spasticity 103
dystonia 102
blepharospasm 36
weakness 34
spasm 33
headache 30
bladder pain 17
pelvic pain 11
paresis 11
functional recovery 10
tremor 10
hypertonia 9
seizures 9
torticollis 7
drooling 7
low back pain 7
Cervical dystonia 6
Spasmodic Torticollis 6
analgesia 6
constipation 6
fatigue 5
arthralgia 5
hemiplegia 5
acidity 5
lethargy 4
dry eye 4
anesthesia 4
orofacial pain 4
back pain 4
Neuropathic pain 4
knee pain 3
discomfort 3
discomfort 3
myalgia 3
insomnia 3
neuralgia 3
muscle stiffness 3
hand pain 3
Chronic pelvic pain 3
motor symptom 2
excessive sweating 2
collapse 2
vomiting 2
neck pain 2
ataxia 2
hypotonia 2
acute pain 2
stridor 2
facial pain 2
limb pain 2
shoulder pain 2
urinary frequency 2
dizziness 1
Hudson 1
Breathiness 1
neurological pain 1
pachyonychia 1
dysarthria 1
Synkinesis 1
syncope 1
dyspnea 1
dysuria 1
Palatal myoclonus 1
overweight 1
twitching 1
pallor 1
paresthesia 1
stigma 1
shortness of breath 1
distraction 1
No toxic effect 1
HSA 1
myoclonus 1
colic 1
respiratory distress 1
Prostatodynia 1
sneezing 1
Motor dysfunction 1
agitation 1
more...
Drug
BoNT/A 444
Botox 39
Dermatol 28
BOTOX 27
Diphenhydramine 13
Myobloc 7
Asn 6
lysine 4
ABC 3
Alanine 3
Fragment 2
lactose 2
Gel 2
Xanthium 1
nitroglycerin 1
Nephron 1
Myricetin 1
NH3 1
Atropine 1
p75 1
CTX 1
Meth 1
pyridoxal phosphate 1
Ammonium chloride 1
Glide 1
Monit 1
IL-2 1
niacin 1
Elm 1
Taxol 1
Kainic acid 1
CSF 1
DNase I 1
Apomorphine 1
Theophylline 1
Nitric Oxide 1
DPA 1
PTC 1
ROC 1
Adenosine triphosphate 1
MAP 1
Ethanol 1
Clopidogrel 1
Enzyme
botulinum neurotoxin 1901
CD10 75
tetanus neurotoxin 44
trypsin 30
protein kinase C 14
ricin 10
thermolysin 9
choline acetyltransferase 9
neuraminidase 8
peroxidase 7
glutathione S-transferase 6
phospholipase A2 6
acetylcholinesterase 5
RNA polymerase 5
proteasome 5
pepsin 4
ATPase 4
ACS 4
PARP 3
mitogen-activated protein kinase 3
ADP-ribosyltransferase 3
alkaline phosphatase 3
ADP-ribosyltransferase 3
prostate-specific antigen 3
phospholipase C 3
reverse transcriptase 3
proteinase K 2
creatine kinase 2
ERK 2
lipase 2
NO synthase 2
BAT 2
protein kinase 2
SPC 2
lactate dehydrogenase 2
tyrosine hydroxylase 2
urease 1
sialidase 1
monoamine oxidase 1
DD-carboxypeptidase 1
clostripain 1
thioredoxin reductase 1
firefly luciferase 1
serralysin 1
sialyltransferase 1
DD-carboxypeptidase 1
cholinesterase 1
kallikrein 1
MIP 1
sialyltransferase 1
caspase-3 1
RNase 1
Hageman factor 1
guanylate cyclase 1
lysozyme 1
histidine kinase 1
DNA ligase 1
endoglycoceramidase 1
thrombin 1
tryptase 1
collagenase 1
RNase 1
histidine decarboxylase 1
PNGase F 1
MAT 1
DAT 1
tissue plasminogen activator 1
deaminase 1
plasmin 1
ACE 1
caspase-9 1
focal adhesion kinase 1
adenosine deaminase 1
transpeptidase 1
dopamine beta-hydroxylase 1
adenylate cyclase 1
glutamine synthetase 1
topoisomerase 1
PKG 1
beta-lactamase 1
more...
Compound
Dec 164
zinc 109
calcium 85
DNA 82
Clin 52
water 45
glutamate 42
sodium 31
tyrosine 27
SDS 26
Botulinum toxin type A 26
arginine 26
sulfate 24
His 22
alanine 20
cysteine 19
ATP 17
phosphate 17
Asp 16
lysine 15
leucine 14
glucose 14
potassium 13
Phe 13
Allergan 13
Diphenhydramine 13
acetate 12
noradrenaline 12
oxygen 10
tryptophan 10
Ile 10
tryptophan 10
ADP 9
tryptophan 9
glycerol 9
tryptophan 9
ADP 9
ADP 9
GM1 9
methanol 8
nitric oxide 8
galactose 8
aluminum 8
EDTA 7
EDTA 7
glutamine 7
silver 6
urea 6
NH2 6
guanidine 6
hydrogen 6
formaldehyde 6
GABA 6
formaldehyde 6
GABA 6
GTP 6
Gly 6
ammonium 6
GM3 5
hydroxide 5
cAMP 5
serine 5
gamma-aminobutyric acid 5
ACh 5
sodium chloride 5
3,4-DAP 5
methionine 5
TOF 5
salt 5
CO2 5
hyaluronic acid 5
HCl 5
ACS 4
iodine 4
Neuronal 4
cGMP 4
aspartic acid 4
threonine 4
ACS 4
NAD 4
more...