Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.69 (
botulinum neurotoxin
)
1,901
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
SNAP
206
heavy chain
154
Sep
132
SNARE
132
syntaxin
82
Mol
64
membrane protein
59
VAMP
51
metalloprotease
46
N-ethylmaleimide-sensitive factor
31
VAMP-2
29
fused
28
SDS
25
axonal
24
polypeptide
21
insulin
17
substance P
17
SV2
17
mer
17
ATP
17
VAMP2
17
syntaxin 1A
16
strabismus
15
SNAP-23
15
Aplysia
15
synaptotagmin II
14
calcitonin
13
gut
12
cellubrevin
10
SV2C
10
serum albumin
9
VAMP1
9
ADP
9
NSF
9
endoprotease
8
choline acetyltransferase
8
amyloid precursor protein
8
neuraminidase
8
P2'
8
nerve growth factor
7
cytokine
7
TRPV1
7
synaptophysin
7
scFv
7
albumin
6
p47
6
C-terminal peptide
6
neuronal protein
6
peroxidase
6
lectin
6
N-ethylmaleimide-sensitive fusion protein
6
GTP
6
GABA
6
MLD
6
CD1
5
TOF
5
CA1
5
synaptotagmin 2
5
glycoprotein
5
She
5
VAMP7
5
NMR
5
CGRP
5
ANOVA
5
endoplasmic reticulum
5
acetylcholinesterase
5
phospholipase A2
5
amylase
5
MHC
5
proteasome
5
C10
4
C15
4
caspase-3
4
prion
4
SV2A
4
ACS
4
thioredoxin
4
synaptotagmin I
4
Met
4
E-cadherin
4
more...
Disease
tetanus
126
stroke
45
cerebral palsy
45
migraine
35
Parkinson's disease
25
SDS
25
chronic pain
23
anthrax
19
depression
19
incontinence
18
interstitial cystitis
18
dysphagia
17
strabismus
17
neuroblastoma
17
multiple sclerosis
15
cancer
14
prolapse
13
cholera
11
movement disorder
10
BPS
9
cold
8
insulinoma
7
osteoarthritis
7
epilepsy
7
incontinence
7
Overactive bladder
6
dysphonia
6
influenza
6
diabetes
6
trigeminal neuralgia
6
metachromatic leukodystrophy
6
infectious diseases
5
Alzheimer's disease
5
toxemia
5
neurological disease
5
parkinsonism
5
urinary tract infection
5
dysautonomia
5
plaque
5
tumor
4
prostatitis
4
neuropathy
4
status epilepticus
4
amyotrophic lateral sclerosis
4
anal fissure
4
varices
4
carpal tunnel syndrome
4
dementia
4
arthritis
4
LCA
4
diplopia
4
diphtheria
4
diabetic neuropathy
4
Dystonia
4
postherpetic neuralgia
4
plantar fasciitis
4
achalasia
4
Chronic migraine
4
nocturia
4
Evans
4
pheochromocytoma
4
xerostomia
4
temporal lobe epilepsy
3
rabies
3
tennis elbow
3
IVA
3
ischemia
3
respiratory failure
3
Venezuelan equine encephalitis
3
psoriasis
3
carcinoma
3
disinhibition
3
ICD
3
akinesia
3
fits
3
hemiparesis
3
muscular atrophy
3
regional pain syndrome
3
HCC
2
Bladder
2
more...
Symptom
pain
153
spasticity
103
dystonia
102
blepharospasm
36
weakness
34
spasm
33
headache
30
bladder pain
17
pelvic pain
11
paresis
11
functional recovery
10
tremor
10
hypertonia
9
seizures
9
torticollis
7
drooling
7
low back pain
7
Cervical dystonia
6
Spasmodic Torticollis
6
analgesia
6
constipation
6
fatigue
5
arthralgia
5
hemiplegia
5
acidity
5
lethargy
4
dry eye
4
anesthesia
4
orofacial pain
4
back pain
4
Neuropathic pain
4
knee pain
3
discomfort
3
discomfort
3
myalgia
3
insomnia
3
neuralgia
3
muscle stiffness
3
hand pain
3
Chronic pelvic pain
3
motor symptom
2
excessive sweating
2
collapse
2
vomiting
2
neck pain
2
ataxia
2
hypotonia
2
acute pain
2
stridor
2
facial pain
2
limb pain
2
shoulder pain
2
urinary frequency
2
dizziness
1
Hudson
1
Breathiness
1
neurological pain
1
pachyonychia
1
dysarthria
1
Synkinesis
1
syncope
1
dyspnea
1
dysuria
1
Palatal myoclonus
1
overweight
1
twitching
1
pallor
1
paresthesia
1
stigma
1
shortness of breath
1
distraction
1
No toxic effect
1
HSA
1
myoclonus
1
colic
1
respiratory distress
1
Prostatodynia
1
sneezing
1
Motor dysfunction
1
agitation
1
more...
Drug
BoNT/A
444
Botox
39
Dermatol
28
BOTOX
27
Diphenhydramine
13
Myobloc
7
Asn
6
lysine
4
ABC
3
Alanine
3
Fragment
2
lactose
2
Gel
2
Xanthium
1
nitroglycerin
1
Nephron
1
Myricetin
1
NH3
1
Atropine
1
p75
1
CTX
1
Meth
1
pyridoxal phosphate
1
Ammonium chloride
1
Glide
1
Monit
1
IL-2
1
niacin
1
Elm
1
Taxol
1
Kainic acid
1
CSF
1
DNase I
1
Apomorphine
1
Theophylline
1
Nitric Oxide
1
DPA
1
PTC
1
ROC
1
Adenosine triphosphate
1
MAP
1
Ethanol
1
Clopidogrel
1
Enzyme
botulinum neurotoxin
1901
CD10
75
tetanus neurotoxin
44
trypsin
30
protein kinase C
14
ricin
10
thermolysin
9
choline acetyltransferase
9
neuraminidase
8
peroxidase
7
glutathione S-transferase
6
phospholipase A2
6
acetylcholinesterase
5
RNA polymerase
5
proteasome
5
pepsin
4
ATPase
4
ACS
4
PARP
3
mitogen-activated protein kinase
3
ADP-ribosyltransferase
3
alkaline phosphatase
3
ADP-ribosyltransferase
3
prostate-specific antigen
3
phospholipase C
3
reverse transcriptase
3
proteinase K
2
creatine kinase
2
ERK
2
lipase
2
NO synthase
2
BAT
2
protein kinase
2
SPC
2
lactate dehydrogenase
2
tyrosine hydroxylase
2
urease
1
sialidase
1
monoamine oxidase
1
DD-carboxypeptidase
1
clostripain
1
thioredoxin reductase
1
firefly luciferase
1
serralysin
1
sialyltransferase
1
DD-carboxypeptidase
1
cholinesterase
1
kallikrein
1
MIP
1
sialyltransferase
1
caspase-3
1
RNase
1
Hageman factor
1
guanylate cyclase
1
lysozyme
1
histidine kinase
1
DNA ligase
1
endoglycoceramidase
1
thrombin
1
tryptase
1
collagenase
1
RNase
1
histidine decarboxylase
1
PNGase F
1
MAT
1
DAT
1
tissue plasminogen activator
1
deaminase
1
plasmin
1
ACE
1
caspase-9
1
focal adhesion kinase
1
adenosine deaminase
1
transpeptidase
1
dopamine beta-hydroxylase
1
adenylate cyclase
1
glutamine synthetase
1
topoisomerase
1
PKG
1
beta-lactamase
1
more...
Compound
Dec
164
zinc
109
calcium
85
DNA
82
Clin
52
water
45
glutamate
42
sodium
31
tyrosine
27
SDS
26
Botulinum toxin type A
26
arginine
26
sulfate
24
His
22
alanine
20
cysteine
19
ATP
17
phosphate
17
Asp
16
lysine
15
leucine
14
glucose
14
potassium
13
Phe
13
Allergan
13
Diphenhydramine
13
acetate
12
noradrenaline
12
oxygen
10
tryptophan
10
Ile
10
tryptophan
10
ADP
9
tryptophan
9
glycerol
9
tryptophan
9
ADP
9
ADP
9
GM1
9
methanol
8
nitric oxide
8
galactose
8
aluminum
8
EDTA
7
EDTA
7
glutamine
7
silver
6
urea
6
NH2
6
guanidine
6
hydrogen
6
formaldehyde
6
GABA
6
formaldehyde
6
GABA
6
GTP
6
Gly
6
ammonium
6
GM3
5
hydroxide
5
cAMP
5
serine
5
gamma-aminobutyric acid
5
ACh
5
sodium chloride
5
3,4-DAP
5
methionine
5
TOF
5
salt
5
CO2
5
hyaluronic acid
5
HCl
5
ACS
4
iodine
4
Neuronal
4
cGMP
4
aspartic acid
4
threonine
4
ACS
4
NAD
4
more...