Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.69 (botulinum neurotoxin)
 1,901 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SNAP 206
heavy chain 154
SNARE 132
Sep 132
syntaxin 82
Mol 64
membrane protein 59
VAMP 51
metalloprotease 46
N-ethylmaleimide-sensitive factor 31
VAMP-2 29
fused 28
SDS 25
axonal 24
polypeptide 21
insulin 17
mer 17
substance P 17
VAMP2 17
ATP 17
SV2 17
syntaxin 1A 16
SNAP-23 15
Aplysia 15
strabismus 15
synaptotagmin II 14
calcitonin 13
gut 12
cellubrevin 10
SV2C 10
VAMP1 9
serum albumin 9
ADP 9
NSF 9
endoprotease 8
amyloid precursor protein 8
neuraminidase 8
P2' 8
choline acetyltransferase 8
cytokine 7
more...
Disease
tetanus 126
cerebral palsy 45
stroke 45
migraine 35
SDS 25
Parkinson's disease 25
chronic pain 23
depression 19
anthrax 19
interstitial cystitis 18
incontinence 18
strabismus 17
dysphagia 17
neuroblastoma 17
multiple sclerosis 15
cancer 14
prolapse 13
cholera 11
movement disorder 10
BPS 9
cold 8
osteoarthritis 7
epilepsy 7
insulinoma 7
incontinence 7
diabetes 6
Overactive bladder 6
dysphonia 6
influenza 6
trigeminal neuralgia 6
metachromatic leukodystrophy 6
Alzheimer's disease 5
plaque 5
toxemia 5
parkinsonism 5
neurological disease 5
urinary tract infection 5
infectious diseases 5
dysautonomia 5
pheochromocytoma 4
more...
Symptom
pain 153
spasticity 103
dystonia 102
blepharospasm 36
weakness 34
spasm 33
headache 30
bladder pain 17
paresis 11
pelvic pain 11
functional recovery 10
tremor 10
seizures 9
hypertonia 9
low back pain 7
torticollis 7
drooling 7
constipation 6
Cervical dystonia 6
analgesia 6
Spasmodic Torticollis 6
fatigue 5
hemiplegia 5
acidity 5
arthralgia 5
dry eye 4
anesthesia 4
Neuropathic pain 4
back pain 4
orofacial pain 4
lethargy 4
muscle stiffness 3
neuralgia 3
discomfort 3
knee pain 3
Chronic pelvic pain 3
myalgia 3
hand pain 3
insomnia 3
discomfort 3
more...
Drug
BoNT/A 444
Botox 39
Dermatol 28
BOTOX 27
Diphenhydramine 13
Myobloc 7
Asn 6
lysine 4
ABC 3
Alanine 3
Gel 2
Fragment 2
lactose 2
Xanthium 1
nitroglycerin 1
Nephron 1
Myricetin 1
NH3 1
Atropine 1
DPA 1
Nitric Oxide 1
Meth 1
Ammonium chloride 1
Glide 1
Monit 1
IL-2 1
niacin 1
Elm 1
Taxol 1
Kainic acid 1
CSF 1
Apomorphine 1
Theophylline 1
DNase I 1
CTX 1
PTC 1
ROC 1
Adenosine triphosphate 1
MAP 1
Ethanol 1
more...
Enzyme
botulinum neurotoxin 1901
CD10 75
tetanus neurotoxin 44
trypsin 30
protein kinase C 14
ricin 10
thermolysin 9
choline acetyltransferase 9
neuraminidase 8
peroxidase 7
glutathione S-transferase 6
phospholipase A2 6
RNA polymerase 5
acetylcholinesterase 5
proteasome 5
ATPase 4
pepsin 4
ACS 4
reverse transcriptase 3
mitogen-activated protein kinase 3
ADP-ribosyltransferase 3
PARP 3
alkaline phosphatase 3
ADP-ribosyltransferase 3
prostate-specific antigen 3
phospholipase C 3
lactate dehydrogenase 2
BAT 2
SPC 2
ERK 2
NO synthase 2
lipase 2
proteinase K 2
protein kinase 2
creatine kinase 2
tyrosine hydroxylase 2
RNase 1
urease 1
PNGase F 1
DD-carboxypeptidase 1
more...
Compound
Dec 164
zinc 109
calcium 85
DNA 82
Clin 52
water 45
glutamate 42
sodium 31
tyrosine 27
Botulinum toxin type A 26
arginine 26
SDS 26
sulfate 24
His 22
alanine 20
cysteine 19
phosphate 17
ATP 17
Asp 16
lysine 15
glucose 14
leucine 14
potassium 13
Diphenhydramine 13
Allergan 13
Phe 13
acetate 12
noradrenaline 12
tryptophan 10
Ile 10
tryptophan 10
oxygen 10
ADP 9
ADP 9
tryptophan 9
glycerol 9
tryptophan 9
GM1 9
ADP 9
methanol 8
more...