Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.69 (botulinum neurotoxin)
 1,901 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SNAP 206
heavy chain 154
Sep 132
SNARE 132
syntaxin 82
Mol 64
membrane protein 59
VAMP 51
metalloprotease 46
N-ethylmaleimide-sensitive factor 31
VAMP-2 29
fused 28
SDS 25
axonal 24
polypeptide 21
mer 17
substance P 17
ATP 17
insulin 17
SV2 17
VAMP2 17
syntaxin 1A 16
strabismus 15
Aplysia 15
SNAP-23 15
synaptotagmin II 14
calcitonin 13
gut 12
cellubrevin 10
SV2C 10
VAMP1 9
NSF 9
ADP 9
serum albumin 9
P2' 8
amyloid precursor protein 8
neuraminidase 8
endoprotease 8
choline acetyltransferase 8
cytokine 7
scFv 7
nerve growth factor 7
synaptophysin 7
TRPV1 7
C-terminal peptide 6
N-ethylmaleimide-sensitive fusion protein 6
lectin 6
albumin 6
GABA 6
peroxidase 6
neuronal protein 6
MLD 6
p47 6
GTP 6
endoplasmic reticulum 5
MHC 5
proteasome 5
VAMP7 5
acetylcholinesterase 5
She 5
CD1 5
NMR 5
synaptotagmin 2 5
phospholipase A2 5
CA1 5
CGRP 5
amylase 5
ANOVA 5
TOF 5
glycoprotein 5
CA3 4
C15 4
MRI 4
prion 4
LCA 4
HCR 4
v-SNARE 4
E-cadherin 4
ACS 4
Met 4
syntaxin 4 4
NMDA receptor 4
AMP 4
C10 4
thioredoxin 4
SV2A 4
synaptotagmin I 4
VRP 4
ATPase 4
caspase-3 4
NK1 3
alkaline phosphatase 3
beta-3 3
ORF 3
olfactory 3
prostate-specific antigen 3
P47 3
chimeric protein 3
p21 3
peptidase 3
glutathione S-transferase 3
member 1 3
CO2 3
ABC 3
aminopeptidase 3
lacrimal 3
titin 3
metabotropic glutamate receptor 3
VAMP-1 3
IVA 3
cell surface receptor 3
HA1 3
ICD 3
L19 3
GST 3
P2X 3
L14 3
syntaxin 3 3
GLUT4 3
complement receptor 3
Rho 3
mast cell 3
MPN 3
ADP-ribosyltransferase 3
Cellubrevin 3
SV2B 3
brain-derived neurotrophic factor 3
HLA 3
alpha-SNAP 3
Trypsin 3
epidermal growth factor 3
muscarinic receptor 3
calcium channel 3
Gen 3
RhoA 3
IgA 3
L12 3
ubiquitin 3
GTPase 3
glial fibrillary acidic protein 3
membrane-bound 3
MEP 3
novel gene 3
NAD+ 2
acetylcholine receptor 2
Pol 2
Q-SNARE 2
CD11b 2
INS-1 2
gephyrin 2
HCC 2
mucin 2
metalloproteinase 2
EGFR 2
TRPA1 2
Pseudomonas 2
L21 2
microsomal 2
X-linked 2
RAZ1 2
ADL 2
HLA-DRB1 2
CD4 2
kit 2
transient receptor potential vanilloid 1 2
C protein 2
tomosyn 2
opioid receptor 2
GalNAcT 2
5-hydroxytryptamine 2
tyrosine hydroxylase 2
hinge 2
reserved 2
Rec 2
mouse) 2
soluble NSF attachment protein 2
ChAT 2
EPM 2
dilute 2
GMP 2
sarcomeric 2
heavy chain variable region 2
IFN 2
L15 2
esterase 2
L10 2
myosin heavy chain 2
serotonin transporter 2
Golgi protein 2
SAR 2
c-Jun 2
gag 2
C11 2
PBS 2
GABA transporter 2
transferrin 2
BAT 2
transcriptional regulator 2
DQB1 2
NAD 2
C21 2
colon carcinoma 2
glucose transporter 2
neurotrophin 2
lactate dehydrogenase 2
nitric oxide synthase 2
NTM 2
dopamine transporter 2
21 kDa protein 2
vesicular acetylcholine transporter 2
lamp 2
IGF-1 2
signal peptidase 2
rat) 2
growth hormone 2
Reelin 2
L18 2
IL-10 2
lipase 2
DQA1 2
L23 2
VCIP135 1
glycoprotein 2 1
Kir6.2 1
p75 1
PTC 1
RNase 1
Titin 1
S100 1
cell surface protein 1
Poly 1
B17 1
metallopeptidase 1
LIF 1
zinc metallopeptidase 1
IL-2 1
PPP 1
NADPH 1
KA2 1
cys 1
matrix metalloproteinase 1
apoptosis-inducing factor 1
chemokine 1
Gag 1
CSF 1
SPR 1
CIC 1
adaptor protein 1
STS 1
HLA DQA1 1
cardiac muscle 1
ATP receptor 1
S100A13 1
VIP2 1
R-SNARE 1
C17 1
L13 1
Mil 1
xenin 1
zinc-binding protein 1
SMA 1
dopamine beta-hydroxylase 1
proteasome inhibitor 1
wts 1
DNMT3B 1
NR2C 1
amisyn 1
triadin 1
purinergic receptor 1
prolactin 1
HES 1
sodium channel 1
HLA-DR3 1
GAT-2 1
ESI 1
MDC 1
glutamine synthetase 1
DNA ligase 1
butyrylcholinesterase 1
MES 1
UTI 1
IgE 1
P2X2 1
caspase-9 1
Rho kinase 1
VAMP-8 1
34 kD 1
cot 1
Dihydrofolate reductase 1
B antigen 1
interferon-gamma 1
LPA 1
Na+/Ca2+ exchanger 1
DSP-4 1
CCL22 1
Synaptophysin 1
RAMP 1
SOD 1
FM1 1
MCP-3 1
vasoactive intestinal peptide 1
synaptotagmin VII 1
NR2B 1
PNG 1
adapter protein 1
amino acid transporter 1
syntaxin-4 1
ABO 1
IDO 1
HA2 1
EGF receptor 1
adenylate cyclase 1
growth hormone releasing hormone 1
FMLP 1
SUFU 1
synaptotagmin IX 1
myostatin 1
thrombin 1
binding peptide 1
ASP 1
more...
Disease
tetanus 126
stroke 45
cerebral palsy 45
migraine 35
SDS 25
Parkinson's disease 25
chronic pain 23
anthrax 19
depression 19
incontinence 18
interstitial cystitis 18
neuroblastoma 17
strabismus 17
dysphagia 17
multiple sclerosis 15
cancer 14
prolapse 13
cholera 11
movement disorder 10
BPS 9
cold 8
incontinence 7
epilepsy 7
insulinoma 7
osteoarthritis 7
trigeminal neuralgia 6
influenza 6
dysphonia 6
diabetes 6
Overactive bladder 6
metachromatic leukodystrophy 6
Alzheimer's disease 5
toxemia 5
parkinsonism 5
dysautonomia 5
neurological disease 5
plaque 5
infectious diseases 5
urinary tract infection 5
arthritis 4
postherpetic neuralgia 4
diphtheria 4
Evans 4
anal fissure 4
carpal tunnel syndrome 4
varices 4
dementia 4
achalasia 4
pheochromocytoma 4
amyotrophic lateral sclerosis 4
plantar fasciitis 4
Chronic migraine 4
status epilepticus 4
prostatitis 4
Dystonia 4
xerostomia 4
nocturia 4
diplopia 4
diabetic neuropathy 4
LCA 4
tumor 4
neuropathy 4
temporal lobe epilepsy 3
carcinoma 3
ischemia 3
regional pain syndrome 3
IVA 3
disinhibition 3
ICD 3
fits 3
muscular atrophy 3
psoriasis 3
Venezuelan equine encephalitis 3
akinesia 3
respiratory failure 3
hemiparesis 3
tennis elbow 3
rabies 3
Equine grass sickness 2
coma 2
hepatocellular carcinoma 2
compartment syndrome 2
rare disease 2
skin disease 2
glioma 2
acute disease 2
Bladder 2
SAR 2
SARS 2
liver cancer 2
dermatitis 2
Blocking 2
ARF 2
virus infection 2
malaria 2
HCC 2
Bladder 2
diplegia 2
Frey 2
gas gangrene 2
obesity 2
apraxia 2
Bladder 2
HIV 2
stress incontinence 2
hyperglycemia 2
mimicry 2
Raynaud 2
gastroparesis 2
acromegaly 2
Hunner 2
mole 2
tetany 1
DIG 1
lupus 1
motor neuron disease 1
mole 1
Hailey-Hailey disease 1
Giant 1
pneumonia 1
leukemia 1
sialadenitis 1
colorectal cancer 1
chronic obstructive pulmonary disease 1
thiamine deficiency 1
EMD 1
Hodgkin's disease 1
lagophthalmos 1
Lower limb 1
triplegia 1
Mitchell 1
bacterial infection 1
lupus 1
HES 1
Downer cow syndrome 1
neuromyotonia 1
neurogenic bladder 1
sensory disturbance 1
nerve entrapment 1
systemic lupus erythematosus 1
glioblastoma 1
PCA 1
Marion 1
fibromyalgia 1
ABS 1
nerve lesion 1
Chronic prostatitis 1
pneumothorax 1
MAS 1
rosacea 1
disuse osteoporosis 1
peripheral neuropathy 1
Poland 1
hydrocephalus 1
Ileum 1
Tongue 1
hypertension 1
smallpox 1
hepatitis E 1
generalized disease 1
Worms 1
acne 1
meningitis 1
Robinson 1
CNS diseases 1
abdominal aortic aneurysm 1
Schmidt 1
Hereditary spastic paraplegia 1
spastic diplegia 1
orphan disease 1
irritable bowel syndrome 1
sepsis 1
bruxism 1
amyloidosis 1
facial palsy 1
EDC 1
AAA 1
transient ischemic attack 1
cardiovascular risk factor 1
dyskinesia 1
PPP 1
Wound botulism 1
Bateman 1
Friedreich's ataxia 1
anemia 1
emotional distress 1
sialolithiasis 1
Adenovirus 1
priapism 1
fecal incontinence 1
MCD 1
orf 1
joint effusion 1
Charcot-Marie-Tooth disease 1
hamartoma 1
urolithiasis 1
rash 1
paraplegia 1
neuromuscular disorder 1
Jensen 1
Thomsen 1
Wallenberg's syndrome 1
PDB 1
Nose 1
prostatic disease 1
medullary thyroid carcinoma 1
Proteus 1
papillary thyroid cancer 1
Hashimoto's thyroiditis 1
hemiparkinsonism 1
cystic fibrosis 1
phantom limb pain 1
pertussis 1
pruritus 1
multiple myeloma 1
Langerhans cell histiocytosis 1
Crohn's disease 1
embryonal carcinoma 1
neuroendocrine tumor 1
sepsis 1
CNF 1
encephalitis 1
Ross syndrome 1
Rosenthal 1
RCM 1
HPP 1
serum sickness 1
sarcoidosis 1
myasthenia gravis 1
Yersinia 1
erectile dysfunction 1
Shiga 1
Mycobacterium 1
Primary focal hyperhidrosis 1
tardive dyskinesia 1
cognitive deficit 1
zoonosis 1
EBM 1
cystitis 1
diabetic retinopathy 1
sudden infant death syndrome 1
carcinoid 1
Lambert-Eaton myasthenic syndrome 1
blindness 1
respiratory acidosis 1
immunodeficiency 1
psychosis 1
hemoglobinuria 1
SEM 1
Still 1
MIP 1
Myofascial pain syndrome 1
LAP 1
aggression 1
STS 1
chondrolysis 1
metastases 1
SCP 1
Infection 1
cleft palate 1
carcinoma in situ 1
autonomic disorder 1
trismus 1
impotence 1
affective disorder 1
tumor growth 1
urethra 1
asthma 1
ventral hernia 1
inflammatory bowel disease 1
HPP 1
glaucoma 1
lipoma 1
PHP 1
PSA 1
astigmatism 1
ABS 1
atherosclerosis 1
esotropia 1
NHS 1
tetraplegia 1
meninges 1
cytomegalovirus 1
hernia 1
Symptom
pain 153
spasticity 103
dystonia 102
blepharospasm 36
weakness 34
spasm 33
headache 30
bladder pain 17
pelvic pain 11
paresis 11
functional recovery 10
tremor 10
hypertonia 9
seizures 9
torticollis 7
drooling 7
low back pain 7
analgesia 6
Cervical dystonia 6
constipation 6
Spasmodic Torticollis 6
arthralgia 5
hemiplegia 5
acidity 5
fatigue 5
dry eye 4
orofacial pain 4
anesthesia 4
back pain 4
Neuropathic pain 4
lethargy 4
hand pain 3
knee pain 3
discomfort 3
myalgia 3
insomnia 3
neuralgia 3
discomfort 3
muscle stiffness 3
Chronic pelvic pain 3
motor symptom 2
excessive sweating 2
collapse 2
vomiting 2
limb pain 2
facial pain 2
ataxia 2
hypotonia 2
acute pain 2
neck pain 2
stridor 2
shoulder pain 2
urinary frequency 2
dizziness 1
Hudson 1
Breathiness 1
neurological pain 1
pachyonychia 1
dysarthria 1
Synkinesis 1
syncope 1
dyspnea 1
dysuria 1
Palatal myoclonus 1
overweight 1
twitching 1
pallor 1
paresthesia 1
stigma 1
Spastic 1
Spasmodic dysphonia 1
No toxic effect 1
Chronic pelvic pain syndrome 1
flushing 1
shortness of breath 1
distraction 1
HSA 1
myoclonus 1
colic 1
respiratory distress 1
Prostatodynia 1
sneezing 1
Motor dysfunction 1
agitation 1
blurred vision 1
clonus 1
leg pain 1
photophobia 1
ophthalmoplegia 1
neurological disability 1
erythema 1
cough 1
diarrhea 1
Drug
BoNT/A 444
Botox 39
Dermatol 28
BOTOX 27
Diphenhydramine 13
Myobloc 7
Asn 6
lysine 4
ABC 3
Alanine 3
Fragment 2
lactose 2
Gel 2
Xanthium 1
nitroglycerin 1
Nephron 1
Myricetin 1
NH3 1
Atropine 1
p75 1
CTX 1
Meth 1
pyridoxal phosphate 1
Ammonium chloride 1
Glide 1
Monit 1
IL-2 1
niacin 1
Elm 1
Taxol 1
Kainic acid 1
CSF 1
DNase I 1
Apomorphine 1
Theophylline 1
Nitric Oxide 1
DPA 1
PTC 1
ROC 1
Adenosine triphosphate 1
MAP 1
Ethanol 1
Clopidogrel 1
Enzyme
botulinum neurotoxin 1901
CD10 75
tetanus neurotoxin 44
trypsin 30
protein kinase C 14
ricin 10
thermolysin 9
choline acetyltransferase 9
neuraminidase 8
peroxidase 7
glutathione S-transferase 6
phospholipase A2 6
acetylcholinesterase 5
RNA polymerase 5
proteasome 5
pepsin 4
ATPase 4
ACS 4
mitogen-activated protein kinase 3
alkaline phosphatase 3
ADP-ribosyltransferase 3
ADP-ribosyltransferase 3
prostate-specific antigen 3
reverse transcriptase 3
phospholipase C 3
PARP 3
lactate dehydrogenase 2
creatine kinase 2
ERK 2
lipase 2
BAT 2
NO synthase 2
protein kinase 2
SPC 2
proteinase K 2
tyrosine hydroxylase 2
urease 1
sialidase 1
monoamine oxidase 1
DD-carboxypeptidase 1
clostripain 1
thioredoxin reductase 1
firefly luciferase 1
serralysin 1
sialyltransferase 1
DD-carboxypeptidase 1
cholinesterase 1
kallikrein 1
MIP 1
sialyltransferase 1
Hageman factor 1
GM3 synthase 1
urease 1
caspase-3 1
PNL 1
dihydrofolate reductase 1
transcriptase 1
histidine kinase 1
endo-beta-galactosidase 1
collagenase 1
RNase 1
histidine decarboxylase 1
PNGase F 1
DNA ligase 1
endoglycoceramidase 1
thrombin 1
tryptase 1
adenosine deaminase 1
luciferase 1
adenosine deaminase 1
transpeptidase 1
dopamine beta-hydroxylase 1
MAT 1
DNA ligase 1
tissue plasminogen activator 1
adenylate cyclase 1
sialyltransferase 1
RNase 1
SCP 1
deaminase 1
plasmin 1
ACE 1
caspase-9 1
focal adhesion kinase 1
endo-beta-galactosidase 1
guanylate cyclase 1
lysozyme 1
glutamine synthetase 1
topoisomerase 1
thiaminase 1
DAT 1
PKG 1
beta-lactamase 1
astacin 1
DNA polymerase 1
MAT 1
aequorin 1
topoisomerase 1
VIP1 1
Compound
Dec 164
zinc 109
calcium 85
DNA 82
Clin 52
water 45
glutamate 42
sodium 31
tyrosine 27
Botulinum toxin type A 26
arginine 26
SDS 26
sulfate 24
His 22
alanine 20
cysteine 19
phosphate 17
ATP 17
Asp 16
lysine 15
leucine 14
glucose 14
Allergan 13
potassium 13
Phe 13
Diphenhydramine 13
noradrenaline 12
acetate 12
oxygen 10
Ile 10
tryptophan 10
tryptophan 10
tryptophan 9
ADP 9
tryptophan 9
glycerol 9
ADP 9
ADP 9
GM1 9
galactose 8
methanol 8
nitric oxide 8
aluminum 8
EDTA 7
glutamine 7
EDTA 7
formaldehyde 6
GABA 6
urea 6
Gly 6
NH2 6
GTP 6
guanidine 6
GABA 6
ammonium 6
hydrogen 6
silver 6
formaldehyde 6
ACh 5
salt 5
CO2 5
cAMP 5
3,4-DAP 5
hydroxide 5
TOF 5
gamma-aminobutyric acid 5
sodium chloride 5
GM3 5
hyaluronic acid 5
methionine 5
HCl 5
serine 5
iodine 4
cGMP 4
NAD 4
threonine 4
GM2 4
AMP 4
ACS 4
aspartic acid 4
ACS 4
Neuronal 4
acrylamide 4
nickel 4
Trypsin 3
isoleucine 3
Mg2+ 3
Tris 3
ethanol 3
iron 3
phenol 3
bromide 3
ADP-ribose 3
GD3 3
Phorbol 3
Tyrosine 3
NMDA 3
myricetin 3
MEP 3
glutamic acid 3
HEPES 3
Alanine 3
isoleucine 3
MEP 3
DMSO 3
PMA 2
fluorine 2
7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol 2
Topiramate 2
DTT 2
Capsaicin 2
Glutamate 2
Neurotol 2
adamantane 2
PMA 2
cobalt 2
copper 2
Tris 2
thiophene 2
GMP 2
manganese 2
Chloroquine 2
A 1 2
proline 2
PEG 2
Triton X-100 2
DMP 2
aspartic acid 2
ethyl acetate 2
nicotinamide 2
nitrogen 2
acetone 2
aspartic acid 2
DTT 2
chloroform 2
NAD 2
tin 2
Optimal 2
Chloroquine 2
GlcNAc 2
aspartic acid 2
nitrate 2
retinoic acid 2
benzaldehyde 1
Glu-Glu 1
BCG 1
Rifampicin 1
Serine 1
4-amino-1-naphthol 1
8-quinolinol 1
HPP 1
Thrombin 1
CNQX 1
dipropyl 1
pyrimidine 1
THF 1
Agar 1
CPA 1
phosphoric acid 1
Nitrendipine 1
benzaldehyde 1
benzaldehyde 1
benzaldehyde 1
Neu5Ac 1
Elan 1
benzaldehyde 1
aldehyde 1
Kainic acid 1
GalNAc 1
isoxazole 1
benzaldehyde 1
DPA 1
DPA 1
selenium 1
chlorine 1
8-quinolinol 1
Norepinephrine 1
Ibotenic acid 1
FMLP 1
benzaldehyde 1
Tacrine 1
Tween 20 1
kaempferol 1
norleucine 1
strontium 1
pyrrolidine 1
PLA 1
DAT 1
5-HT 1
8-quinolinol 1
benzaldehyde 1
6-12 1
Yellow 1
benzaldehyde 1
1,2-cyclohexanedione 1
stearic acid 1
stearic acid 1
POP 1
ASA 1
DPA 1
Adriamycin 1
norleucine 1
benzaldehyde 1
nitrosobenzene 1
Wortmannin 1
benzaldehyde 1
Brefeldin A 1
tungsten 1
CPA 1
DPA 1
benzaldehyde 1
MES 1
Off 1
barium 1
Sarcosine 1
Testosterone 1
Iodoacetamide 1
APV 1
Testosterone 1
cadmium 1
Triton 1
MPA 1
8-quinolinol 1
1,3,5-hexatriene 1
keratan sulfate 1
Paclitaxel 1
PMB 1
DEAE 1
adenylate 1
ONA 1
benzaldehyde 1
nitrous acid 1
benzaldehyde 1
Theophylline 1
benzaldehyde 1
3-piperidinecarboxylic acid 1
benzaldehyde 1
GDP 1
MAD 1
mercury 1
benzaldehyde 1
CPA 1
benzaldehyde 1
Amphetamine 1
Adenosine 1
Elan 1
Risedronate 1
B17 1
dUTP 1
disialyllactose 1
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1
benzaldehyde 1
Calcein 1
aldehyde 1
PDB 1
benzaldehyde 1
Kainic acid 1
benzaldehyde 1
MPA 1
AAA 1
Tetrodotoxin 1
hexane 1
benzaldehyde 1
BMC 1
DPA 1
pyrrolidine 1
benzaldehyde 1
TSH 1
ammonia 1
L-leucine 1
BON 1
benzaldehyde 1
benzaldehyde 1
NTA 1
hippurate 1
methane 1
MES 1
MNT 1
Saxitoxin 1
DNP 1
DSM 1
ACM 1
Isoform 1
NADPH 1
stearic acid 1
benzaldehyde 1
Ibotenic acid 1
8-quinolinol 1
MPTP 1
8-quinolinol 1
H2S 1
DPA 1
NADPH 1
1,3,5-hexatriene 1
H2S 1
CTX 1
DAB 1
dicarboxylic acid 1
EDC 1
Amide 1
TCA 1
ADR 1
A 150 1
benzoic acid 1
PEG 1
8-quinolinol 1
CPA 1
DPA 1
Amphetamine 1
DPA 1
His-Leu 1
Atropine 1
DPA 1
AMPA 1
DPA 1
4-AP 1
Progesterone 1
Valproic acid 1
Cysteine 1
Nodular 1
more...