Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.69 (botulinum neurotoxin)
 1,901 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
RAZ1 12.7
synaptotagmin II 11.9
SV2C 11.7
synaptotagmin IX 11.7
syntaxin 1C 11.7
Cellubrevin 11.3
Myopalladin 11.2
HECTD2 11.2
VAMP5 11.0
SNAP protein 10.9
VAMP 10.7
VAMP1 10.6
synaptotagmin 2 10.5
VAMP-1 10.4
VAMP-2 10.2
amisyn 10.2
CDIP 10.0
VCIP135 9.9
SNAP-47 9.9
SNAP 9.8
Vesicle-associated membrane protein 2 9.8
SV2B 9.6
VAMP2 9.6
SNAP-23 9.6
cellubrevin 9.6
syntaxin 9.5
syntaxin 1A 9.5
VRP 9.5
SV2 9.4
SNARE 9.3
gcv 9.2
synaptotagmin VII 9.1
tomosyn 9.0
VAMP7 9.0
SV2A 8.9
N-ethylmaleimide-sensitive factor 8.9
syntaxin 3 8.8
Synaptosomal-associated protein 8.8
syntaxin 4 8.7
21 kDa protein 8.7
N-ethylmaleimide-sensitive fusion protein 8.7
Q-SNARE 8.6
P47 8.4
syntaxin 1B 8.3
alpha-SNAP 8.3
AAAT 8.3
GAT-2 8.2
HLA DQA1 8.1
VIP2 8.1
MAPA 8.0
VAMP4 7.9
P2' 7.9
BTF 7.9
TSN 7.9
MLD 7.9
heavy chain 7.8
LCB 7.8
S100A13 7.8
L21 7.7
choline acetylase 7.7
synaptotagmin I 7.7
L19 7.7
GLYT1 7.7
VAMP-8 7.7
L14 7.7
CARP 7.6
v-SNARE 7.6
NSF 7.6
C1D 7.5
HCR 7.5
LNP 7.4
Hb1 7.4
soluble NSF attachment protein 7.4
GalNAc-transferase 7.3
BSG 7.3
metalloprotease 7.3
P33 7.3
endoprotease 7.3
VAMP3 7.2
P140 7.2
zinc metallopeptidase 7.2
SUFU 7.2
GalNAcT 7.1
R-SNARE 7.1
BASP1 7.1
Glycophorin A 7.0
heavy chain variable region 7.0
34 kD 7.0
neuronal protein 6.9
GM3 synthase 6.8
KA1 6.8
zinc-binding protein 6.7
beta-3 6.7
KChIP2 6.7
RAMP 6.7
L15 6.7
synaptotagmin 1 6.7
L23 6.7
dynamin 1 6.6
MNT 6.6
LCE 6.6
PNG 6.5
ST7 6.5
glycoprotein 2 6.5
L18 6.5
KA2 6.5
EPM 6.3
L13 6.3
24 kDa protein 6.3
ST4 6.3
syntaxin-4 6.3
L30 6.3
L17 6.2
xenin 6.2
Aplysia 6.1
NBP 6.1
p47 6.0
MNB 6.0
L22 6.0
strabismus 6.0
telomerase catalytic subunit 6.0
TCI 5.9
prothymosin alpha 5.9
GAT1 5.9
L12 5.9
GHRH receptor 5.9
LCA 5.8
elastase inhibitor 5.8
LPA1 5.8
gephyrin 5.8
Myosin heavy chain 5.8
N-acetylgalactosaminyltransferase 5.8
ATP receptor 5.7
growth hormone releasing hormone 5.7
CD205 5.7
Nav1.7 5.7
L10 5.6
MEP 5.6
Myf-5 5.6
Dihydrofolate reductase 5.6
ADP-ribosyltransferase 5.6
NR2C 5.6
ChAT 5.6
choline transporter 5.6
HA1 5.6
actin-depolymerizing factor 5.6
RIL 5.5
Titin 5.5
Golgi protein 5.5
vesicular acetylcholine transporter 5.5
Drosophila) 5.5
L16 5.5
MPN 5.5
CGRP 5.5
GAP43 5.5
chromogranin B 5.4
amphiphysin 5.4
cot 5.4
TRPV1 5.4
myelin protein zero 5.3
more...
Disease
Downer cow syndrome 12.4
Equine grass sickness 11.3
Primary focal hyperhidrosis 9.8
Hunner 9.3
Wound botulism 9.3
triplegia 9.1
Chronic migraine 9.1
Ross syndrome 8.7
BPS 8.3
Overactive bladder 8.0
interstitial cystitis 7.9
Myofascial pain syndrome 7.8
autonomic disorder 7.6
anal fissure 7.5
tetanus 7.4
tennis elbow 7.1
plantar fasciitis 7.0
Ileum 6.8
disuse osteoporosis 6.7
Dystonia 6.6
hemiparkinsonism 6.6
dysautonomia 6.5
cerebral palsy 6.3
Wallenberg's syndrome 6.3
metachromatic leukodystrophy 6.3
anthrax 6.3
Chronic prostatitis 6.2
diplegia 6.1
toxemia 6.0
Bateman 5.8
nocturia 5.8
orphan disease 5.8
chondrolysis 5.7
dysphonia 5.6
lagophthalmos 5.6
regional pain syndrome 5.5
Venezuelan equine encephalitis 5.5
gas gangrene 5.5
EBM 5.5
postherpetic neuralgia 5.5
DIG 5.4
Hailey-Hailey disease 5.4
Hereditary spastic paraplegia 5.4
sialolithiasis 5.4
Marion 5.3
trigeminal neuralgia 5.2
generalized disease 5.2
movement disorder 5.2
SCP 5.2
migraine 5.1
neuromyotonia 5.1
LCA 5.1
Lower limb 5.1
PHP 5.0
insulinoma 5.0
CNF 4.9
strabismus 4.9
HPP 4.9
phantom limb pain 4.9
Thomsen 4.9
HPP 4.8
spastic diplegia 4.8
hemoglobinuria 4.8
ventral hernia 4.8
MCD 4.8
Lambert-Eaton myasthenic syndrome 4.7
serum sickness 4.6
prostatitis 4.6
joint effusion 4.6
gastroparesis 4.6
achalasia 4.6
IVA 4.5
incontinence 4.5
Worms 4.5
akinesia 4.5
tetany 4.4
Raynaud 4.4
prostatic disease 4.4
chronic pain 4.3
nerve entrapment 4.2
ABS 4.2
diabetic neuropathy 4.2
prolapse 4.2
orf 4.2
dysphagia 4.2
Tongue 4.1
ABS 4.1
Rosenthal 4.1
acute disease 4.0
xerostomia 4.0
HES 4.0
esotropia 3.9
trismus 3.9
bruxism 3.9
sialadenitis 3.9
carpal tunnel syndrome 3.8
PPP 3.8
nerve lesion 3.8
LAP 3.8
sensory disturbance 3.8
thiamine deficiency 3.8
incontinence 3.7
diplopia 3.7
Bladder 3.7
Bladder 3.7
Bladder 3.7
Frey 3.7
neuromuscular disorder 3.7
RCM 3.6
priapism 3.6
apraxia 3.6
EMD 3.5
Mitchell 3.5
HCC 3.5
respiratory acidosis 3.5
rosacea 3.4
disinhibition 3.4
neuroblastoma 3.4
compartment syndrome 3.3
EDC 3.3
neurogenic bladder 3.2
status epilepticus 3.2
neurological disease 3.2
diphtheria 3.2
cholera 3.2
Jensen 3.1
stress incontinence 3.1
Robinson 3.1
cardiovascular risk factor 3.1
SDS 3.1
acromegaly 3.0
temporal lobe epilepsy 3.0
Friedreich's ataxia 3.0
hemiparesis 2.9
fecal incontinence 2.9
urinary tract infection 2.8
cognitive deficit 2.8
neuroendocrine tumor 2.8
STS 2.7
Parkinson's disease 2.7
tardive dyskinesia 2.7
CNS diseases 2.7
rabies 2.7
Schmidt 2.6
muscular atrophy 2.6
varices 2.6
multiple sclerosis 2.5
parkinsonism 2.5
mimicry 2.5
motor neuron disease 2.5
tetraplegia 2.5
ARF 2.5
Charcot-Marie-Tooth disease 2.5
AAA 2.5
Evans 2.5
ICD 2.4
hepatitis E 2.4
Adenovirus 2.4
astigmatism 2.4
Langerhans cell histiocytosis 2.4
more...
Symptom
Spasmodic Torticollis 10.2
Prostatodynia 10.1
Cervical dystonia 9.9
Synkinesis 9.6
bladder pain 9.5
blepharospasm 9.2
Chronic pelvic pain syndrome 9.2
neurological pain 9.1
Breathiness 9.1
Palatal myoclonus 8.9
Spasmodic dysphonia 8.1
spasticity 8.1
Chronic pelvic pain 8.0
hand pain 7.9
No toxic effect 7.7
dystonia 7.7
Motor dysfunction 7.7
drooling 7.4
hypertonia 6.9
Spastic 6.6
pachyonychia 6.5
spasm 6.2
torticollis 6.2
motor symptom 6.2
orofacial pain 6.1
excessive sweating 5.9
limb pain 5.6
Neuropathic pain 5.6
pelvic pain 5.5
muscle stiffness 5.4
paresis 5.0
urinary frequency 4.9
neuralgia 4.9
dry eye 4.7
clonus 4.5
hemiplegia 4.4
neurological disability 4.2
knee pain 4.2
Hudson 4.0
weakness 3.9
stridor 3.8
facial pain 3.8
functional recovery 3.6
shoulder pain 3.6
low back pain 3.6
lethargy 3.6
arthralgia 3.5
photophobia 3.4
constipation 3.3
pain 3.3
tremor 3.2
headache 3.2
sneezing 3.1
neck pain 3.1
acute pain 3.1
leg pain 3.0
twitching 3.0
blurred vision 3.0
myalgia 2.9
dysuria 2.8
pallor 2.7
hypotonia 2.5
HSA 2.5
acidity 2.5
back pain 2.5
colic 2.4
ophthalmoplegia 2.3
insomnia 2.2
dysarthria 2.2
myoclonus 2.0
analgesia 1.8
paresthesia 1.8
shortness of breath 1.7
flushing 1.4
discomfort 1.2
ataxia 1.1
discomfort 1.0
seizures 0.9
syncope 0.9
distraction 0.8
dizziness 0.8
fatigue 0.7
agitation 0.5
erythema 0.3
stigma 0.3
collapse 0.2
vomiting 0.1
respiratory distress -0.2
cough -0.5
overweight -0.7
anesthesia -0.7
dyspnea -0.7
diarrhea -1.8
Drug
BoNT/A 13.1
BOTOX 11.4
Myobloc 11.0
Botox 10.6
Elm 8.0
Diphenhydramine 7.7
Ammonium chloride 6.2
Myricetin 5.8
Glide 4.7
Kainic acid 4.7
Xanthium 4.3
Adenosine triphosphate 4.2
Alanine 4.2
Clopidogrel 3.9
Fragment 3.9
Apomorphine 3.8
DPA 3.7
Meth 3.6
PTC 3.3
Asn 3.1
Theophylline 3.0
pyridoxal phosphate 2.7
Nitric Oxide 2.7
ABC 2.5
Taxol 2.4
Atropine 2.3
niacin 2.2
p75 2.1
NH3 1.2
Gel 1.2
ROC 1.1
DNase I 1.0
lactose 1.0
nitroglycerin 0.9
Dermatol 0.8
Ethanol 0.8
CTX 0.7
lysine 0.2
MAP 0.1
Nephron -0.1
IL-2 -0.8
CSF -0.9
Monit -1.1
Enzyme
botulinum neurotoxin 14.0
tetanus neurotoxin 11.9
serralysin 7.9
endoglycoceramidase 7.7
thiaminase 7.7
CD10 7.0
DD-carboxypeptidase 6.6
VIP1 6.6
thermolysin 6.3
GM3 synthase 6.3
astacin 6.1
clostripain 6.1
DD-carboxypeptidase 6.1
ricin 5.7
endo-beta-galactosidase 5.7
ADP-ribosyltransferase 5.6
PNL 5.6
ADP-ribosyltransferase 5.6
BAT 5.3
SCP 5.2
endo-beta-galactosidase 5.1
Hageman factor 5.0
choline acetyltransferase 4.6
SPC 3.7
dopamine beta-hydroxylase 3.6
trypsin 3.6
aequorin 3.5
transpeptidase 3.5
histidine decarboxylase 3.5
DAT 3.5
MAT 3.5
PNGase F 3.5
sialyltransferase 3.4
sialyltransferase 3.4
sialyltransferase 3.4
MAT 3.3
neuraminidase 3.2
proteinase K 3.0
pepsin 3.0
prostate-specific antigen 2.9
phospholipase A2 2.8
histidine kinase 2.8
thioredoxin reductase 2.8
PKG 2.7
sialidase 2.6
DNA ligase 2.6
DNA ligase 2.6
tryptase 2.6
firefly luciferase 2.6
protein kinase C 2.3
glutathione S-transferase 2.2
PARP 1.9
MIP 1.8
glutamine synthetase 1.7
deaminase 1.7
adenosine deaminase 1.7
adenosine deaminase 1.7
acetylcholinesterase 1.6
proteasome 1.5
dihydrofolate reductase 1.5
kallikrein 1.5
phospholipase C 1.4
RNA polymerase 1.3
urease 1.2
tyrosine hydroxylase 1.2
urease 1.2
caspase-9 1.2
NO synthase 1.1
guanylate cyclase 1.0
plasmin 0.9
topoisomerase 0.9
lipase 0.8
peroxidase 0.8
creatine kinase 0.8
transcriptase 0.8
topoisomerase 0.8
reverse transcriptase 0.7
monoamine oxidase 0.6
tissue plasminogen activator 0.6
cholinesterase 0.4
beta-lactamase 0.3
lactate dehydrogenase 0.2
alkaline phosphatase 0.1
ATPase 0.0
RNase 0.0
DNA polymerase -0.0
RNase -0.1
ACE -0.1
collagenase -0.1
adenylate cyclase -0.2
ACS -0.2
lysozyme -0.4
mitogen-activated protein kinase -0.9
thrombin -1.0
caspase-3 -1.1
luciferase -1.2
protein kinase -1.3
focal adhesion kinase -1.4
ERK -1.5
Compound
7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol 13.4
Botulinum toxin type A 10.7
4-amino-1-naphthol 10.1
disialyllactose 10.0
3-piperidinecarboxylic acid 9.8
3,4-DAP 8.8
Allergan 8.8
Diphenhydramine 8.3
8-quinolinol 7.1
8-quinolinol 7.1
8-quinolinol 7.1
8-quinolinol 7.1
8-quinolinol 7.1
8-quinolinol 7.0
A 150 7.0
Saxitoxin 6.9
Iodoacetamide 6.9
1,2-cyclohexanedione 6.6
Risedronate 6.5
Elan 6.5
8-quinolinol 6.5
MNT 6.5
8-quinolinol 6.3
Sarcosine 6.2
Elan 6.2
PMB 6.2
nitrosobenzene 6.1
BON 5.9
Ibotenic acid 5.9
Ibotenic acid 5.9
Topiramate 5.8
Tacrine 5.8
ONA 5.7
MEP 5.6
MEP 5.5
Calcein 5.4
GM2 5.3
GM3 5.3
Nitrendipine 5.2
His-Leu 5.2
GD3 5.1
Alum 5.0
DETA 5.0
B17 4.9
Glu-Glu 4.9
myricetin 4.9
Isoform 4.8
Kainic acid 4.7
Kainic acid 4.7
Phorbol 4.6
GM1 4.6
adamantane 4.5
HEPES 4.4
zinc 4.4
MAD 4.3
Brefeldin A 4.3
Brefeldin A 4.3
norleucine 4.3
Alanine 4.2
Nodular 4.2
Chloroquine 4.2
Chloroquine 4.2
DMP 4.1
DTT 4.1
hippurate 4.1
DTT 4.0
norleucine 4.0
Trypsin 3.9
DPA 3.9
DPA 3.9
4-AP 3.9
Wortmannin 3.9
FMLP 3.9
DPA 3.8
dipropyl 3.8
DPA 3.7
keratan sulfate 3.7
POP 3.7
DPA 3.7
MES 3.7
MES 3.7
Tyrosine 3.7
1,3,5-hexatriene 3.7
1,3,5-hexatriene 3.7
Capsaicin 3.7
1,3,5-hexatriene 3.7
MPA 3.6
DAB 3.6
MPA 3.6
DPA 3.6
CNQX 3.6
HPP 3.5
MPA 3.5
DAT 3.5
APV 3.5
DPA 3.5
Tetrodotoxin 3.5
DPA 3.5
DPA 3.5
DPA 3.5
DPA 3.5
DPA 3.5
guanidine 3.5
CPA 3.4
Amide 3.4
Amphetamine 3.4
Amphetamine 3.4
CPA 3.3
CPA 3.3
glutamate 3.3
EDC 3.2
ACh 3.2
nitrous acid 3.2
ADP-ribose 3.1
Tween 20 3.1
Agar 3.0
CPA 3.0
SDS 3.0
Ile 3.0
Rifampicin 3.0
Asp 2.9
sodium chloride 2.9
L-leucine 2.8
hyaluronic acid 2.8
NTA 2.7
isoxazole 2.7
Neu5Ac 2.7
formaldehyde 2.7
noradrenaline 2.6
Theophylline 2.6
Neuronal 2.6
Paclitaxel 2.5
thiophene 2.5
aspartic acid 2.5
AAA 2.5
ACM 2.5
gamma-aminobutyric acid 2.4
A 1 2.4
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2.4
Glutamate 2.4
Substance P 2.4
formaldehyde 2.3
Atropine 2.3
Cysteine 2.3
Serine 2.3
Valproic acid 2.3
isoleucine 2.3
DNP 2.3
Tris 2.3
isoleucine 2.3
aluminum 2.2
alanine 2.2
His 2.2
tyrosine 2.2
tryptophan 2.2
arginine 2.2
PDB 2.2
Neurotol 2.2
glutamine 2.1
EDTA 2.1
more...