Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.69 (botulinum neurotoxin)
 1,901 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SNAP 206
heavy chain 154
SNARE 132
Sep 132
syntaxin 82
Mol 64
membrane protein 59
VAMP 51
metalloprotease 46
N-ethylmaleimide-sensitive factor 31
VAMP-2 29
fused 28
SDS 25
axonal 24
polypeptide 21
substance P 17
ATP 17
insulin 17
SV2 17
mer 17
VAMP2 17
syntaxin 1A 16
strabismus 15
SNAP-23 15
Aplysia 15
synaptotagmin II 14
calcitonin 13
gut 12
SV2C 10
cellubrevin 10
NSF 9
ADP 9
serum albumin 9
VAMP1 9
P2' 8
neuraminidase 8
amyloid precursor protein 8
choline acetyltransferase 8
endoprotease 8
synaptophysin 7
scFv 7
cytokine 7
TRPV1 7
nerve growth factor 7
lectin 6
GABA 6
GTP 6
peroxidase 6
N-ethylmaleimide-sensitive fusion protein 6
albumin 6
MLD 6
neuronal protein 6
C-terminal peptide 6
p47 6
CD1 5
amylase 5
VAMP7 5
proteasome 5
ANOVA 5
synaptotagmin 2 5
NMR 5
acetylcholinesterase 5
She 5
CGRP 5
TOF 5
phospholipase A2 5
CA1 5
MHC 5
endoplasmic reticulum 5
glycoprotein 5
NMDA receptor 4
CA3 4
VRP 4
syntaxin 4 4
prion 4
ACS 4
v-SNARE 4
Met 4
AMP 4
C10 4
MRI 4
C15 4
HCR 4
SV2A 4
synaptotagmin I 4
caspase-3 4
E-cadherin 4
ATPase 4
thioredoxin 4
LCA 4
glutathione S-transferase 3
alpha-SNAP 3
mast cell 3
alkaline phosphatase 3
chimeric protein 3
NK1 3
olfactory 3
HA1 3
ICD 3
L14 3
L19 3
RhoA 3
ORF 3
beta-3 3
P47 3
GST 3
syntaxin 3 3
peptidase 3
lacrimal 3
P2X 3
prostate-specific antigen 3
aminopeptidase 3
IVA 3
VAMP-1 3
metabotropic glutamate receptor 3
cell surface receptor 3
ABC 3
CO2 3
titin 3
GLUT4 3
epidermal growth factor 3
ubiquitin 3
IgA 3
calcium channel 3
Cellubrevin 3
Gen 3
ADP-ribosyltransferase 3
brain-derived neurotrophic factor 3
member 1 3
Trypsin 3
SV2B 3
Rho 3
muscarinic receptor 3
GTPase 3
L12 3
MPN 3
glial fibrillary acidic protein 3
p21 3
membrane-bound 3
complement receptor 3
HLA 3
MEP 3
novel gene 3
metalloproteinase 2
mucin 2
colon carcinoma 2
NTM 2
C21 2
HLA-DRB1 2
lactate dehydrogenase 2
NAD+ 2
X-linked 2
RAZ1 2
glucose transporter 2
opioid receptor 2
mouse) 2
C protein 2
tomosyn 2
GalNAcT 2
dopamine transporter 2
more...
Disease
tetanus 126
cerebral palsy 45
stroke 45
migraine 35
Parkinson's disease 25
SDS 25
chronic pain 23
anthrax 19
depression 19
interstitial cystitis 18
incontinence 18
neuroblastoma 17
dysphagia 17
strabismus 17
multiple sclerosis 15
cancer 14
prolapse 13
cholera 11
movement disorder 10
BPS 9
cold 8
incontinence 7
epilepsy 7
osteoarthritis 7
insulinoma 7
trigeminal neuralgia 6
influenza 6
diabetes 6
dysphonia 6
Overactive bladder 6
metachromatic leukodystrophy 6
dysautonomia 5
plaque 5
urinary tract infection 5
Alzheimer's disease 5
toxemia 5
neurological disease 5
infectious diseases 5
parkinsonism 5
plantar fasciitis 4
LCA 4
diplopia 4
pheochromocytoma 4
anal fissure 4
carpal tunnel syndrome 4
dementia 4
achalasia 4
varices 4
neuropathy 4
tumor 4
arthritis 4
Dystonia 4
nocturia 4
Chronic migraine 4
diabetic neuropathy 4
status epilepticus 4
xerostomia 4
prostatitis 4
amyotrophic lateral sclerosis 4
postherpetic neuralgia 4
Evans 4
diphtheria 4
carcinoma 3
regional pain syndrome 3
temporal lobe epilepsy 3
rabies 3
tennis elbow 3
respiratory failure 3
ICD 3
disinhibition 3
Venezuelan equine encephalitis 3
psoriasis 3
hemiparesis 3
muscular atrophy 3
akinesia 3
fits 3
IVA 3
ischemia 3
HIV 2
stress incontinence 2
skin disease 2
gastroparesis 2
mimicry 2
acromegaly 2
Hunner 2
Equine grass sickness 2
glioma 2
acute disease 2
SARS 2
compartment syndrome 2
liver cancer 2
dermatitis 2
Bladder 2
rare disease 2
coma 2
Raynaud 2
malaria 2
Bladder 2
apraxia 2
Frey 2
hepatocellular carcinoma 2
gas gangrene 2
diplegia 2
obesity 2
Bladder 2
HCC 2
ARF 2
virus infection 2
Blocking 2
hyperglycemia 2
SAR 2
mole 2
sialadenitis 1
chronic obstructive pulmonary disease 1
DIG 1
Infection 1
Hodgkin's disease 1
mole 1
Giant 1
pneumonia 1
inflammatory bowel disease 1
lagophthalmos 1
MIP 1
SCP 1
glaucoma 1
neuromyotonia 1
neurogenic bladder 1
sensory disturbance 1
tumor growth 1
glioblastoma 1
HPP 1
fibromyalgia 1
ABS 1
lupus 1
pneumothorax 1
MAS 1
rosacea 1
disuse osteoporosis 1
systemic lupus erythematosus 1
PCA 1
Marion 1
nerve lesion 1
Chronic prostatitis 1
Poland 1
Ileum 1
Tongue 1
peripheral neuropathy 1
hydrocephalus 1
hypertension 1
smallpox 1
hepatitis E 1
generalized disease 1
Worms 1
acne 1
meningitis 1
spastic diplegia 1
Schmidt 1
sepsis 1
bruxism 1
facial palsy 1
more...
Symptom
pain 153
spasticity 103
dystonia 102
blepharospasm 36
weakness 34
spasm 33
headache 30
bladder pain 17
pelvic pain 11
paresis 11
functional recovery 10
tremor 10
hypertonia 9
seizures 9
torticollis 7
drooling 7
low back pain 7
analgesia 6
Cervical dystonia 6
constipation 6
Spasmodic Torticollis 6
arthralgia 5
hemiplegia 5
acidity 5
fatigue 5
dry eye 4
orofacial pain 4
anesthesia 4
back pain 4
Neuropathic pain 4
lethargy 4
hand pain 3
knee pain 3
discomfort 3
myalgia 3
insomnia 3
neuralgia 3
discomfort 3
muscle stiffness 3
Chronic pelvic pain 3
motor symptom 2
excessive sweating 2
collapse 2
vomiting 2
limb pain 2
facial pain 2
ataxia 2
hypotonia 2
acute pain 2
neck pain 2
stridor 2
shoulder pain 2
urinary frequency 2
dizziness 1
Hudson 1
Breathiness 1
neurological pain 1
pachyonychia 1
dysarthria 1
Synkinesis 1
syncope 1
dyspnea 1
dysuria 1
Palatal myoclonus 1
overweight 1
twitching 1
pallor 1
paresthesia 1
stigma 1
Spastic 1
Spasmodic dysphonia 1
No toxic effect 1
Chronic pelvic pain syndrome 1
flushing 1
shortness of breath 1
distraction 1
HSA 1
myoclonus 1
colic 1
respiratory distress 1
Prostatodynia 1
sneezing 1
Motor dysfunction 1
agitation 1
blurred vision 1
clonus 1
leg pain 1
photophobia 1
ophthalmoplegia 1
neurological disability 1
erythema 1
cough 1
diarrhea 1
Drug
BoNT/A 444
Botox 39
Dermatol 28
BOTOX 27
Diphenhydramine 13
Myobloc 7
Asn 6
lysine 4
ABC 3
Alanine 3
Fragment 2
lactose 2
Gel 2
Xanthium 1
nitroglycerin 1
Nephron 1
Myricetin 1
NH3 1
Atropine 1
p75 1
CTX 1
Meth 1
pyridoxal phosphate 1
Ammonium chloride 1
Glide 1
Monit 1
IL-2 1
niacin 1
Elm 1
Taxol 1
Kainic acid 1
CSF 1
DNase I 1
Apomorphine 1
Theophylline 1
Nitric Oxide 1
DPA 1
PTC 1
ROC 1
Adenosine triphosphate 1
MAP 1
Ethanol 1
Clopidogrel 1
Enzyme
botulinum neurotoxin 1901
CD10 75
tetanus neurotoxin 44
trypsin 30
protein kinase C 14
ricin 10
thermolysin 9
choline acetyltransferase 9
neuraminidase 8
peroxidase 7
glutathione S-transferase 6
phospholipase A2 6
acetylcholinesterase 5
RNA polymerase 5
proteasome 5
pepsin 4
ATPase 4
ACS 4
mitogen-activated protein kinase 3
alkaline phosphatase 3
ADP-ribosyltransferase 3
ADP-ribosyltransferase 3
prostate-specific antigen 3
reverse transcriptase 3
phospholipase C 3
PARP 3
lactate dehydrogenase 2
creatine kinase 2
ERK 2
lipase 2
BAT 2
NO synthase 2
protein kinase 2
SPC 2
proteinase K 2
tyrosine hydroxylase 2
urease 1
sialidase 1
monoamine oxidase 1
DD-carboxypeptidase 1
clostripain 1
thioredoxin reductase 1
firefly luciferase 1
serralysin 1
sialyltransferase 1
DD-carboxypeptidase 1
cholinesterase 1
kallikrein 1
MIP 1
sialyltransferase 1
Hageman factor 1
GM3 synthase 1
urease 1
caspase-3 1
PNL 1
dihydrofolate reductase 1
transcriptase 1
histidine kinase 1
endo-beta-galactosidase 1
collagenase 1
RNase 1
histidine decarboxylase 1
PNGase F 1
DNA ligase 1
endoglycoceramidase 1
thrombin 1
tryptase 1
adenosine deaminase 1
luciferase 1
adenosine deaminase 1
transpeptidase 1
dopamine beta-hydroxylase 1
MAT 1
DNA ligase 1
tissue plasminogen activator 1
adenylate cyclase 1
sialyltransferase 1
RNase 1
SCP 1
deaminase 1
plasmin 1
ACE 1
caspase-9 1
focal adhesion kinase 1
endo-beta-galactosidase 1
guanylate cyclase 1
lysozyme 1
glutamine synthetase 1
topoisomerase 1
thiaminase 1
DAT 1
PKG 1
beta-lactamase 1
astacin 1
DNA polymerase 1
MAT 1
aequorin 1
topoisomerase 1
VIP1 1
Compound
Dec 164
zinc 109
calcium 85
DNA 82
Clin 52
water 45
glutamate 42
sodium 31
tyrosine 27
arginine 26
SDS 26
Botulinum toxin type A 26
sulfate 24
His 22
alanine 20
cysteine 19
phosphate 17
ATP 17
Asp 16
lysine 15
glucose 14
leucine 14
Phe 13
potassium 13
Allergan 13
Diphenhydramine 13
noradrenaline 12
acetate 12
oxygen 10
Ile 10
tryptophan 10
tryptophan 10
ADP 9
GM1 9
glycerol 9
tryptophan 9
ADP 9
ADP 9
tryptophan 9
galactose 8
methanol 8
aluminum 8
nitric oxide 8
glutamine 7
EDTA 7
EDTA 7
NH2 6
ammonium 6
Gly 6
formaldehyde 6
GABA 6
hydrogen 6
urea 6
GTP 6
formaldehyde 6
guanidine 6
GABA 6
silver 6
GM3 5
serine 5
hyaluronic acid 5
TOF 5
gamma-aminobutyric acid 5
cAMP 5
CO2 5
ACh 5
3,4-DAP 5
salt 5
HCl 5
methionine 5
hydroxide 5
sodium chloride 5
ACS 4
aspartic acid 4
cGMP 4
iodine 4
threonine 4
GM2 4
ACS 4
Neuronal 4
NAD 4
AMP 4
acrylamide 4
nickel 4
DMSO 3
isoleucine 3
ADP-ribose 3
isoleucine 3
MEP 3
Tris 3
NMDA 3
Tyrosine 3
Trypsin 3
GD3 3
Phorbol 3
iron 3
Mg2+ 3
phenol 3
bromide 3
myricetin 3
glutamic acid 3
HEPES 3
Alanine 3
ethanol 3
MEP 3
proline 2
PEG 2
Optimal 2
GlcNAc 2
Topiramate 2
PMA 2
chloroform 2
DTT 2
nicotinamide 2
aspartic acid 2
tin 2
acetone 2
fluorine 2
Glutamate 2
nitrate 2
Triton X-100 2
aspartic acid 2
adamantane 2
cobalt 2
copper 2
DMP 2
NAD 2
manganese 2
ethyl acetate 2
PMA 2
aspartic acid 2
A 1 2
thiophene 2
GMP 2
Tris 2
nitrogen 2
Chloroquine 2
7-(phenyl(8-quinolinylamino)methyl)-8-quinolinol 2
DTT 2
Neurotol 2
Capsaicin 2
Chloroquine 2
retinoic acid 2
benzaldehyde 1
benzaldehyde 1
Glu-Glu 1
Serine 1
Rifampicin 1
HPP 1
AAA 1
dipropyl 1
pyrimidine 1
THF 1
DPA 1
benzaldehyde 1
phosphoric acid 1
ammonia 1
BON 1
benzaldehyde 1
benzaldehyde 1
more...