Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: EC:3.4.24.69 (
botulinum neurotoxin
)
1,901
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies have demonstrated that botulinum toxin type A (BoNT-A) attenuates orofacial nociception. However, there has been no evidence of the participation of the voltage-gated sodium channels (Navs) in the antinociceptive mechanisms of
BoNT
-A. This study investigated the cellular mechanisms underlying the antinociceptive effects of
BoNT
-A in a male Sprague-Dawley rat model of trigeminal neuropathic pain produced by malpositioned dental implants. The left mandibular second molar was extracted under anesthesia, followed by a miniature dental implant placement to induce injury to the inferior alveolar nerve. Mechanical allodynia was monitored after subcutaneous injection of
BoNT
-A at 3, 7, or 12 d after malpositioned dental implant surgery. Subcutaneous injections of 1 or 3 U/kg of
BoNT
-A on postoperative day 3 significantly attenuated mechanical allodynia, although 0.3 U/kg of
BoNT
-A did not affect the air-puff threshold. A single injection of 3 U/kg of
BoNT
-A produced prolonged antiallodynic effects over the entire experimental period. Treatment with
BoNT
-A on postoperative days 7 and 12, when pain had already been established, also produced prolonged antiallodynic effects. Double treatments with 1 U/kg of
BoNT
-A produced prolonged, more antiallodynic effects as compared with single treatments. Subcutaneous administration of 3 U/kg of
BoNT
-A significantly inhibited the upregulation of Nav isoform 1.7 (
Nav1.7
) expression in the trigeminal ganglion in the nerve-injured animals. These results suggest that antinociceptive effects of
BoNT
-A are mediated by an inhibition of upregulated
Nav1.7
expression in the trigeminal ganglion.
BoNT
-A is therefore a potential new therapeutic agent for chronic pain control, including neuropathic pain.
...
PMID:Antinociceptive Effects of Botulinum Toxin Type A on Trigeminal Neuropathic Pain. 2741 74
