Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.64 (MPP)
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Human Gene/Protein
FLJ32798 14.1
MPP 14.1
parkin isoform 13.1
PMPCA 12.7
EMTh 12.5
MTERFD3 12.5
plasma membrane Ca(2+)-ATPase isoform 2 12.1
MEF2D protein 11.9
YME1L1 11.9
VAM-1 11.7
Myocyte enhancer factor 2D 11.7
SLC22A15 11.7
MPP6 11.7
mitochondrial intermediate peptidase 11.6
B3GALT4 11.5
RNF13 11.5
tryptase epsilon 11.2
PreP 11.2
PCD17 11.1
SLC22A23 11.1
BPOZ 11.1
LIM domain kinase 2 11.1
extraneuronal monoamine transporter 11.0
plasma membrane monoamine transporter 10.9
myocyte enhancer factor 2D 10.9
MPP5 10.9
Cytochrome P4502D6 10.9
PEMP 10.9
NSUN4 10.9
organic cation transporter 3 10.8
SLC22A3 10.7
BNIP2 10.7
MPP7 10.7
hOCT2 10.7
SLC22A17 10.6
iron-sulfur protein 3 10.6
LIN7C 10.6
TIMM23 10.6
LIN7B 10.6
INADL 10.5
RNF138 10.5
NGP1 10.5
MPP-9 10.4
SLC41A2 10.4
dimethylglycine dehydrogenase 10.4
FASTKD2 10.2
organic cation transporter 1 10.2
thiamine transporter 1 10.1
MTERF 10.1
translocase of the inner mitochondrial membrane 10.1
F1 beta subunit 10.1
SCG3 10.1
G1L 10.1
OCT2 10.0
OCT1 10.0
DLGAP4 10.0
OPA1 protein 9.9
seven in absentia homolog 1 9.9
MPP4 9.9
MPP2 9.9
SLC22A2 9.7
ALPI 9.7
LIN7 9.7
calcium binding and coiled-coil domain 2 9.7
MPP10 9.7
NPM1 protein 9.7
TFAM protein 9.7
MPP3 9.7
organic cation transporter 9.6
RBM3 9.5
organic cation transporter 2 9.5
PDIp 9.5
UCP4 9.4
PPT 9.4
THTR2 9.4
NgR3 9.4
TP53INP2 9.4
MPDZ 9.4
QCR8 9.4
SLC22A1 9.3
hOAT4 9.3
somatostatin receptor 1 9.2
CHAC1 9.2
cytochrome c oxidase subunit 3 9.2
TRPC1 protein 9.2
ubiquinol-cytochrome c reductase complex 9.2
MATE1 9.2
polo-like kinase 2 9.2
GPR6 9.2
TRA2B 9.2
ALG2 9.1
Voltage-gated potassium channel 9.1
UFD1 9.1
Tom5 9.1
vacuolar protein sorting 35 9.1
Lipoyl synthase 9.0
NgR2 9.0
PGAM5 9.0
cytochrome bc1 9.0
Fibroblast growth factor 9 8.9
insulysin 8.9
Histone deacetylase 4 8.9
MT-CO2 8.9
Necl-4 8.9
glia maturation factor 8.9
NFE2L1 8.9
LPP 8.9
PALS1 8.9
ARHGAP26 8.8
Methionine sulfoxide reductase 8.8
putative serine/threonine protein kinase 8.8
COX4I2 8.8
CASP-1 8.8
MATE2-K 8.8
BAG6 8.8
G15 8.7
SCG2 8.7
activating transcription factor 5 8.7
OCT3 8.7
Frataxin 8.7
CCT2 8.7
PRDX5 8.7
Synphilin-1 8.7
RTN1 8.7
CNNM2 8.7
Monoamine oxidase B 8.6
secretogranin III 8.6
LONP1 8.6
ATPase subunit 9 8.6
COQ7 8.6
ferrocytochrome c:oxygen oxidoreductase 8.6
NPTX2 8.6
nardilysin 8.6
MPP1 8.5
CRB3 8.5
HPTP 8.5
PAK-1 8.5
EPP 8.5
PEP1 8.5
SLC30A10 8.4
TBN 8.4
AIMP2 8.4
Sab 8.4
PITSLRE 8.4
SKI-1 8.4
PSST 8.4
VMAT2 8.4
Rieske iron-sulfur protein 8.3
GPER 8.3
DLP1 8.3
clone 10 8.3
LETM1 8.3
PATJ 8.3
NIPA1 8.3
BAT3 8.3
THTR-1 8.2
NDUFS3 8.2
sirtuin 2 8.2
MT-ND6 8.2
AIFM1 8.2
more...
Disease
RP24 11.2
RHN 10.9
Lichen planus pemphigoides 9.1
panmyelosis 8.8
Age-related cognitive decline 8.7
manic disorder 8.7
Complex I deficiency 8.1
Frontal fibrosing alopecia 7.9
Parkinson's disease 7.8
FRDA 7.7
Pituitary gland 7.7
Pituitary gland 7.7
Pituitary gland 7.7
Klebsiella infection 7.6
PARK7 7.6
disorders of iron metabolism 7.4
PARK6 7.4
OPA1 7.3
lgl 7.2
Hallervorden-Spatz disease 7.1
RDP 6.8
parkinsonism 6.8
PARK2 6.6
AD2 6.6
hemiparkinsonism 6.6
neuroblastoma 6.5
codependency 6.4
nagana 6.4
PAPA 6.4
erythropoietic protoporphyria 6.3
MSF 6.3
BOS 6.2
PPP 6.2
Friedreich's ataxia 6.0
MIN 6.0
MIN 6.0
Mycoplasma pneumoniae pneumonia 6.0
HPP 5.9
BPP 5.9
HPP 5.8
movement disorder 5.8
Landau-Kleffner syndrome 5.8
CLN1 5.8
FHF 5.7
DMT1 5.6
glutaric aciduria 5.6
Forbes 5.5
CEP 5.3
MEC 5.2
THC 5.2
pica 5.2
Morquio 5.2
BPS 5.1
AAA 5.1
Class III malocclusion 5.0
Pineal 4.9
excessive drinking 4.9
vascular obstruction 4.9
granulosa cell tumor 4.8
GSH 4.7
LIN 4.6
localized infection 4.6
ERS 4.5
pheochromocytoma 4.5
Cannabis 4.4
multiple disorders 4.4
catalepsy 4.4
PDC 4.4
MSA 4.3
dyskinesia 4.3
MTS 4.2
HTS 4.2
HCA 4.2
PNS 4.2
neurosyphilis 4.2
EMT 4.2
behavior disorder 4.1
Testes 4.1
TAS 4.0
neuronal ceroid lipofuscinosis 4.0
Angelman syndrome 4.0
PAL 4.0
Ovary 3.9
vitreous humor 3.9
optic atrophy 3.9
akinesia 3.9
PER 3.9
MDS 3.8
renal ischemia 3.8
MIP 3.7
CNS diseases 3.7
EPS 3.7
DDP 3.7
Pulmonary arterial hypertension 3.6
achondroplasia 3.6
infectious endocarditis 3.6
abdominal aortic aneurysm 3.6
nicotine addiction 3.5
EPS 3.5
tetanus 3.4
genital herpes 3.3
progressive supranuclear palsy 3.3
lichen 3.3
hyperostosis 3.3
respiratory infection 3.3
Fibrillation 3.3
FBS 3.2
PAM 3.2
AGA 3.2
Blocking 3.2
TCP 3.2
mitochondrial disease 3.2
Ovary 3.2
myelofibrosis 3.2
choriocarcinoma 3.1
melioidosis 3.1
Alzheimer's disease 3.1
NPC 3.0
osteoma 3.0
IVA 3.0
NAME 2.9
bacterial pneumonia 2.9
NOD 2.9
Huntington's disease 2.9
Mycoplasma 2.8
ovarian cysts 2.8
HSP 2.8
diplopia 2.7
PDE 2.7
narcolepsy 2.7
BDE 2.7
Schmidt 2.7
T-cell lymphomas 2.7
malignant mesothelioma 2.6
cerebral ischemia 2.6
degenerative disease 2.6
African trypanosomiasis 2.5
sympathomimetic 2.5
ACP 2.5
Gaucher disease 2.5
iron overload 2.5
Tourette syndrome 2.4
pemphigoid 2.4
filariasis 2.4
sclera 2.4
lichen planus 2.3
domestic violence 2.3
embryonal carcinoma 2.3
craniosynostosis 2.3
medullary thyroid carcinoma 2.3
claudication 2.3
Wright 2.2
gingivitis 2.2
insulinoma 2.2
retinoblastoma 2.2
amyotrophic lateral sclerosis 2.2
lymphoblastic leukemia 2.1
MCF 2.1
B-cell lymphoma 2.0
ATM 2.0
more...
Symptom
bradykinesia 6.0
Scratch 5.4
motor symptom 5.2
sinus pressure 5.0
muscle rigidity 4.0
collapse 3.2
chorea 3.0
tremor 2.7
hypothermia 2.3
cerebellar ataxia 2.2
functional recovery 1.9
acidity 1.7
hypotonia 1.5
starvation 1.4
exhaustion 1.3
nausea and vomiting 0.8
constipation 0.7
thinning 0.6
stigma 0.3
ataxia 0.1
fatigue -0.0
weakness -0.2
discomfort -0.5
seizures -0.7
diarrhea -1.8
anesthesia -2.7
pain -2.9
Drug
5-Nitroindazole 14.1
6-Nitroindazole 12.5
Bupleurum root 10.9
Asoprisnil 10.5
Alsterpaullone 10.5
Fidarestat 9.2
Fidarestat 9.2
Epalrestat 8.4
7-Nitroindazole 7.6
Valproic Acid 7.5
Ddc 7.4
Quinine, 7.4
Pramipexole 7.4
Pramipexole 7.3
Madopar 7.2
Parkin 7.2
Parkin 7.2
Tenoxicam 7.1
Vandetanib 7.0
Myricetin 6.8
3-Methyladenine 6.7
SPP 6.5
CFT 6.4
ICI 6.4
Tween 60 6.4
Ipratropium bromide 6.3
Poloxamer 188 6.3
Cytidine 6.2
Swertia 6.2
Compound 9 6.1
EMB 6.0
Ringer's solution 5.8
Rimonabant 5.7
Reserpine 5.7
Fulvestrant 5.6
Zonisamide 5.5
Rosiglitazone 5.4
Rolipram 5.3
ROS 5.2
ISP 5.2
PFT 5.1
BH4 5.1
Glutamic acid 5.1
Misoprostol 5.0
Salicylate 4.9
Emodin 4.9
Gefitinib 4.8
Digitalis 4.8
EE2 4.7
Gelfoam 4.5
OTC 4.5
Estrogens 4.5
TEL 4.4
SF6 4.3
Oxaliplatin 4.2
FAD 4.2
TAK 4.1
Heme 4.0
Ketoconazole 4.0
OTC 4.0
Clopidogrel 3.9
MDS 3.9
NADH 3.9
RFP 3.8
Apomorphine 3.8
DPA 3.7
Lovastatin 3.7
Ginseng 3.4
9-THC 3.3
Glutathione 3.2
Fructose 3.2
DHT 2.9
Captopril 2.9
DHT 2.9
EPA 2.8
TAT 2.8
Ouabain 2.8
Fraction 2.7
caffeine 2.7
Fluorescein 2.6
MAP 2.4
Retinoic acid 2.3
Glucagon 2.2
Fluorescein 2.2
niacin 2.2
ascorbate 2.1
Spectrum 2.1
Portal 2.0
ENT 2.0
vitamin E 1.5
lysine 1.5
Bifidobacterium 1.5
Indomethacin 1.4
Gel 1.2
Spectrum 1.1
citric acid 0.8
CSF 0.7
Leaf 0.6
IFN-gamma -0.8
IL-2 -0.8
Dermatol -4.0
Enzyme
MPP 14.1
N-acetyl-gamma-glutamyl-phosphate reductase 11.2
oligopeptidase A 10.6
dimethylglycine dehydrogenase 10.4
i-AAA protease 10.2
Mucor pusillus rennin 10.1
6-hydroxy-D-nicotine oxidase 9.9
m-AAA protease 9.5
ubiquinol-cytochrome c oxidoreductase 9.2
N-acetylglutamate kinase 8.2
nardilysin 8.1
protease La 8.1
complex I 7.9
N-acetylglutamate synthase 7.3
tyrosine hydroxylase 7.3
site-1 protease 7.2
RGP 7.2
DAT 7.1
LipA 6.8
N-acetylglutamate synthase 6.8
kynurenine aminotransferase 6.6
insulin-degrading enzyme 6.5
prostacyclin synthase 6.5
phosphatidylserine decarboxylase 6.4
thimet oligopeptidase 6.4
pregnancy-associated plasma protein-A 6.3
monoamine oxidase 6.3
glutaryl-CoA dehydrogenase 6.3
PTR 6.3
NADH dehydrogenase 6.2
pantothenate kinase 6.1
caspase-3 6.0
thromboxane synthase 5.9
fumarase 5.9
aconitase 5.9
dimethylarginine dimethylaminohydrolase 5.8
diaphorase 5.8
GSK 5.7
MsrA 5.7
MIP 5.7
caspase-9 5.6
Lys4 5.6
gamma-glutamylcysteine synthetase 5.6
CEP 5.5
SNO 5.5
caspase-2 5.5
branched-chain alpha-keto acid dehydrogenase 5.4
transaldolase 5.4
methylmalonyl-CoA mutase 5.4
GABA transaminase 5.4
caspase-2 5.4
PKG 5.3
TPP 5.3
IscS 5.3
acetyl-CoA synthetase 5.2
ferrochelatase 5.2
glucosylceramide synthase 5.1
TPP 5.1
aldehyde reductase 5.1
aldehyde reductase 5.0
NQO1 5.0
CPR 5.0
aldehyde reductase 5.0
MMP 5.0
CEP 4.9
flavin-containing monooxygenase 4.9
glycine decarboxylase 4.9
ornithine transcarbamylase 4.9
serine hydroxymethyltransferase 4.9
adrenodoxin reductase 4.8
uricase 4.8
prolyl hydroxylase 4.8
diamine oxidase 4.8
arylsulfatase A 4.8
acetolactate synthase 4.7
ATP synthase 4.7
PARP 4.7
cellulose synthase 4.7
malate dehydrogenase 4.7
GTP cyclohydrolase I 4.7
poly(A) polymerase 4.7
monoacylglycerol lipase 4.6
SMP 4.6
PGM 4.6
ornithine aminotransferase 4.6
exoribonuclease 4.5
aldehyde oxidase 4.5
rhodanese 4.5
succinate dehydrogenase 4.5
AMP-activated protein kinase 4.5
superoxide dismutase 4.5
peptidyl-prolyl cis-trans isomerase 4.4
AMPK 4.4
MEK 4.4
lactate dehydrogenase 4.3
phosphatidylinositol 3-kinase 4.3
paraoxonase 4.3
KAT 4.3
caspase-7 4.2
Pla 4.2
NOS 4.2
glutathione peroxidase 4.2
caspase-7 4.2
MEKK1 4.2
thermolysin 4.2
glutaminase 4.2
GAS 4.1
PRE 4.1
phosphoinositide 3-kinase 4.1
mitogen-activated protein kinase 4.1
ALA synthase 4.1
aldehyde dehydrogenase 4.0
isocitrate dehydrogenase 4.0
paraoxonase 4.0
DOPA decarboxylase 4.0
caspase-1 4.0
chaperonin 4.0
aldehyde dehydrogenase 4.0
aldehyde dehydrogenase 4.0
cytochrome oxidase 3.9
aldehyde dehydrogenase 3.9
isocitrate dehydrogenase 3.9
pyruvate dehydrogenase 3.9
pyruvate dehydrogenase 3.9
xanthine oxidase 3.8
cellulose synthase 3.7
alpha-ketoglutarate dehydrogenase 3.7
NADPH oxidase 3.7
NO synthase 3.7
cellobiohydrolase 3.7
MDP 3.7
luciferase 3.6
caspase-8 3.6
AMPK 3.6
tryptase 3.6
heme oxygenase 3.6
NADPH oxidase 3.6
catalase 3.6
dihydrofolate reductase 3.5
glucocerebrosidase 3.5
citrate synthase 3.5
pyruvate carboxylase 3.5
triphosphatase 3.5
apyrase 3.5
proteasome 3.4
PAL 3.4
aldehyde dehydrogenase 3.4
aldose reductase 3.4
dipeptidyl peptidase IV 3.3
PTA 3.3
succinic dehydrogenase 3.3
endoglycosidase H 3.2
pyruvate dehydrogenase 3.2
PAM 3.2
phosphorylase 3.2
TdT 3.2
P-glycoprotein 3.2
DCF 3.1
BAL 3.1
cathepsin D 3.0
more...
Compound
5-Nitroindazole 14.1
MPP 14.0
MPP 14.0
MPDP 13.2
1-Methyl-4-phenylpyridinium 13.1
1-(2-pyridinyl)piperazine 11.7
6-Nitroindazole 11.7
Silychristin 11.5
4-phenylpyridine 11.3
1,10-decanedithiol 10.9
N-Formylkynurenine 10.6
Amdro 10.6
Chebulagic acid 10.5
Bruceine D 10.5
Chebulagic acid 10.5
3,4-Dihydroxyphenylacetaldehyde 10.5
Purpald 10.4
MPTP 10.3
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 10.3
4-phenyl-1,2,3,6-tetrahydropyridine 10.2
1-methyl-1,2,3,6-tetrahydropyridine 10.1
Retrorsine 10.1
Retrorsine 10.1
1-benzyl-1,2,3,4-tetrahydroisoquinoline 10.0
Chebulinic acid 9.7
BKF 9.6
Schisantherin A 9.5
Schisantherin A 9.5
Farrerol 9.5
Jatrorrhizine 9.3
Ginkgetin 9.3
DPN 9.3
Kavain 9.1
Tectorigenin 9.1
Carnosol 9.0
Rhynchophylline 9.0
DHBA 8.7
MK 571 8.7
Catalpol 8.6
Angelicin 8.6
UH-301 8.6
N-phenylbenzamide 8.5
Echinacoside 8.4
Tetrahydrocurcumin 8.4
Myricitrin 8.4
1,2,3,6-tetrahydropyridine 8.2
1,2,3,6-tetrahydropyridine 8.2
Tetrabenazine 8.2
HPTE 8.1
TPB 8.1
Loganin 8.0
Maneb 7.9
mCPBG 7.9
Selegiline 7.9
Geranylgeranylacetone 7.9
MCPP 7.8
Zingerone 7.8
1H-pyrazole 7.8
7-Ketocholesterol 7.8
Pinocembrin 7.7
Econazole 7.6
1,2,3,4-tetrahydroisoquinoline 7.6
FMI 7.6
1H-pyrazole 7.5
Hydroxocobalamin 7.5
1-(3-chlorophenyl)piperazine 7.5
LY 294002 7.5
Econazole 7.5
Tyrosol 7.5
cholest-4-en-3-one 7.5
Hyperoside 7.4
Danshensu 7.4
Phenelzine 7.4
Protoporphyrin IX 7.4
Ginkgolide B 7.3
Scopoletin 7.3
3-Deazaneplanocin 7.3
Edaravone 7.3
Phenelzine 7.3
NIX 7.3
Embelin 7.2
Asiatic acid 7.2
Oxybutynin 7.2
Zinc protoporphyrin 7.2
Methyl parathion 7.2
DAT 7.1
Paraquat 7.1
Oxymatrine 7.1
22R-hydroxycholesterol 7.0
Formononetin 7.0
Riluzole 7.0
Rotenone 7.0
Puerarin 6.9
Paraquat 6.9
Harmaline 6.9
1,2,4-benzenetriol 6.9
Cromakalim 6.9
Paeoniflorin 6.8
Clorgyline 6.8
Fucoidan 6.8
TCN 6.8
Pergolide 6.8
Rosmarinic acid 6.7
Rosmarinic acid 6.7
EOC 6.7
Amantadine 6.7
Amantadine 6.7
3-Methyladenine 6.7
Meloxicam 6.7
6-Hydroxydopamine 6.6
Amantadine 6.6
Nobiletin 6.6
1-benzofuran 6.5
Sesamin 6.5
Monocrotaline 6.5
Phenothiazine 6.5
Kynurenic acid 6.5
octanoyl-CoA 6.5
ubiquinol 6.5
2-methyl-2,4-pentanediol 6.5
Nonylphenol 6.4
8-hydroxyguanosine 6.4
Zonisamide 6.4
Oridonin 6.4
Magnolol 6.3
Glyoxylate 6.3
Amantadine 6.3
Acetyl-L-carnitine 6.3
(-)-Epigallocatechin 6.2
HPP 6.1
ICI 6.1
Rottlerin 6.1
GA1 6.1
Silymarin 6.1
CoQ 6.1
MEP 6.1
DHBA 6.1
Rottlerin 6.0
Griseofulvin 6.0
Rottlerin 6.0
Griseofulvin 6.0
Desipramine 6.0
Lithium chloride 6.0
DLG 6.0
TEA 6.0
TEA 5.9
FBF 5.9
MEP 5.9
MPB 5.9
Clavulanic acid 5.9
Phytic acid 5.8
Diazinon 5.8
Chrysin 5.8
2-phosphoglycerate 5.8
NPR 5.8
Thiabendazole 5.8
2,4,5-T 5.8
Melamine 5.7
MES 5.7
MES 5.7
more...