Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.64 (
MPP
)
1,876
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cytochrome c reductase
from potato is a bifunctional protein complex located in the inner mitochondrial membrane, which is involved in respiratory electron transport and processing of mitochondrial precursor proteins. The three largest subunits of the complex share the highest degree of sequence identity with the alpha- and beta-subunits of the soluble processing peptidase (
MPP
) from fungi and mammals. Evidence is provided that another substoichiometric polypeptide of the cytochrome c reductase complex resembles the alpha-subunit of
MPP
. A cDNA clone corresponding to the second alpha-
MPP
protein (alpha-II
MPP
) encodes a polypeptide of 504 amino acids which is 84% identical to alpha-I
MPP
. The two different alpha-
MPP
polypeptides have similar sizes on SDS-polyacrylamide gels but can be distinguished with an antibody raised against a decapeptide that is specific for alpha-II
MPP
. The presequences of both alpha-subunits of
MPP
are proteolytically removed by the integrated processing enzyme complex indicating that it acts on the targeting signals of its own precursor proteins. Gene-specific oligonucleotides reveal that the genes encoding alpha-subunit I and alpha-subunit II of
MPP
are differentially expressed in all tissues analysed but the transcript levels do not vary between tissues.
...
PMID:The mitochondrial processing peptidase from potato: a self-processing enzyme encoded by two differentially expressed genes. 781 32
Cytochrome c reductase
from potato has been extensively studied with respect to its catalytic activities, its subunit composition, and the biogenesis of individual subunits. Molecular characterization of all 10 subunits revealed that the high-molecular-weight subunits exhibit striking homologies with the components of the general
mitochondrial processing peptidase
(
MPP
) from fungi and mammals. Some of the other subunits show differences in the structure of their targeting signals or in their molecular composition when compared to their counterparts from heterotrophic organisms. The proteolytic activity of
MPP
was found in the cytochrome c reductase complexes from potato, spinach, and wheat, suggesting that the integration of the protease into this respiratory complex is a general feature of higher plants.
...
PMID:The bifunctional cytochrome c reductase/processing peptidase complex from plant mitochondria. 859 78
