Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.64 (
MPP
)
1,876
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We have investigated here the mechanism of dephosphorylation and activation of
death-associated protein kinase
(
DAPK
) and the role of lysosome in neuroblastoma cells (SH-SY5Y) treated with mitochondrial toxins, such as
MPP
(+) and rotenone. Mitochondrial respiratory chain inhibitors and uncouplers decreased mitochondrial membrane potential leading to
DAPK
dephosphorylation and activation. The class III phosphoinositide 3-kinase inhibitors attenuated
DAPK
dephosphorylation induced by mitochondrial toxins. Complex I inhibition by mitochondrial toxins (e.g.
MPP
(+)) resulted in mitochondrial swelling and lysosome reduction. Inhibition of class III phosphoinositide 3-kinase attenuated
MPP
(+)-induced lysosome reduction and cell death. The role of
DAPK
as a sensor of mitochondrial membrane potential in mitochondrial diseases was addressed.
...
PMID:Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. 1608 44
