Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: EC:3.4.24.64 (
MPP
)
1,876
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of alkaloid piperine against the toxicity of 1-methyl-4-phenylpyridinium (
MPP
(+)) in differentiated PC12 cells was assessed.
Piperine
treatment revealed a differential effect on the cytotoxicity of
MPP
(+) and had its maximum inhibitory effect at 1 microM. The addition of piperine (0.5-10 microM) significantly reduced the
MPP
(+)-induced nuclear damage, mitochondrial membrane permeability changes, formation of reactive oxygen species and depletion of GSH. In contrast, piperine at 50-100 microM showed cytotoxicity and exhibited an additive effect against the
MPP
(+) toxicity. The results indicate that piperine had a differential effect on the cytotoxicity of
MPP
(+) depending on concentration.
Piperine
at low concentrations may reduce the
MPP
(+)-induced viability loss in PC12 cells by suppressing the changes in the mitochondrial membrane permeability, leading to the release of cytochrome c and subsequent activation of caspase-3. The effects may be ascribed to its inhibitory action on the formation of reactive oxygen species and depletion of GSH.
...
PMID:Piperine inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells. 1662 79
