Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.64 (MPP)
 1,876 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1-(o-methoxyphenyl)-piperazine (o-MPP) is regarded as an antagonist of the dopamine receptor. Its effects were studied for the hind limb flexor reflex in the spinal rat, the body temperature in rats maintained at ambient temperature of 28 degrees C and stereotypy induced in rats by a low dose of apomorphine (0.5 mg/kg). o-MPP (2-12.5 mg/kg) stimulated the flexor reflex and, in higher doses (10-40 mg/kg), elevated the body temperature of heat-adapted rats. Both effects were inhibited by central serotonin receptor blocking agents--cyproheptadine or metergoline. Low doses of o-MPP (below 5 mg/kg) did not affect stereotypy induced by apomorphine; higher doses (5-25 mg/kg) attenuated the stereotypy in a dose-dependent manner. The results obtained suggest that o-MPP may facilitate the central serotonergic transmission similarly as several other phenylpiperazines. The role of this effect in the "antidopamine" action of o-MPP is discussed.
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PMID:A serotonergic component in the central action of 1-(o-methoxyphenyl)-piperazine. 666 37

Solid phase chemistry with UltraLink Iodoacetyl gel was investigated as a method for removing excess ligand present in preparations of diaminedithiol (DADT) 99mTc radiopharmaceuticals. The process was optimized and tested under 99mTc labeling conditions with 2,2,4,9,9-pentamethyl-4,7-diaza-1,10-decanedithiol (N-methyl-DADT), 1, and 4-(1-(2'-methoxyphenyl) piperazinylbutyl)-2,2,9,9-tetramethyl-4,7-diaza-1,10 -decanedithiol (DADT-4C-MPP), 2, a serotonin receptor-binding ligand. The results illustrated that this gel removed > or = 99.9% excess ligand used in labeling reactions, and was comparable to the level of purification usually obtained by the more labor intensive method of HPLC.
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PMID:Validation and application of a solid phase chemistry method for preparation of high effective specific activity technetium-99m radiopharmaceuticals. 931 76