Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.59 (MIP)
 4,906 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
MIP 4876
cytokine 1061
chemokine 996
IL-6 877
MCP-1 848
TNF 762
RANTES 645
IL-8 589
IL-10 456
IFN 392
CXCL10 330
Sep 319
TNF-alpha 310
lipopolysaccharide 280
IL-4 255
Mol 249
tumor necrosis factor 246
MIP-1alpha 240
LPS 233
GM-CSF 225
IL-2 205
IL-17 199
CCL3 187
CCR5 167
IL-13 164
IFN-gamma 163
CD4 163
CCL2 157
TLR4 156
interferon 154
Cytokine 152
G-CSF 142
IL-1 132
IL-5 129
tumor necrosis factor alpha 128
myeloperoxidase 122
CCL4 122
VEGF 120
p38 119
CD8 116
MIP-1beta 116
ICAM-1 113
eotaxin 112
RANTES) 109
monocyte chemoattractant protein-1 109
CXCL2 108
CXCL1 105
inducible nitric oxide synthase 100
C-C 94
MCP-3 91
MAPK 89
GRO 89
CCL20 88
IL-1 beta 87
CCR1 85
CXCL9 84
CXCR2 84
monocyte chemotactic protein 83
interleukin-6 80
CC chemokine 79
TLR2 79
IL-7 78
IL-15 77
CXC chemokine 77
monocyte chemoattractant protein 76
chemokine receptor 71
CD11b 70
collagen 68
insulin 66
Eotaxin 66
macrophage colony-stimulating factor 64
THP 63
vascular endothelial growth factor 62
interferon-gamma 60
p65 59
ERK1 59
IL-18 59
CD14 58
MEP 58
ERK 57
NIP 57
lymphoid 57
JNK 56
vascular cell adhesion molecule-1 56
IL-9 51
MyD88 51
CD86 51
IL-3 50
TGF-beta 50
Pseudomonas 50
MCP 49
gut 48
CCR6 47
CXCL12 47
granulocyte-macrophage colony-stimulating factor 47
MMP-9 46
CCR2 45
CSF 43
major intrinsic protein 42
PDGF 42
CXCL5 42
albumin 41
MCP-2 41
granulocyte 39
mitochondrial intermediate peptidase 38
CXCR4 37
caspase-3 36
CCL 36
IL-1 alpha 35
COX-2 35
IL-1ra 35
CCL17 35
granulocyte colony-stimulating factor 34
CD40 34
serum albumin 34
CCR7 34
CXCR3 33
ATAC 32
CD80 32
CCR3 31
fractalkine 31
PI3K 31
NMR 31
adhesion molecule 30
IgE 30
FGF 30
lysozyme 29
PBS 29
E-selectin 29
CD18 29
P-selectin 29
intercellular adhesion molecule-1 29
ECL 29
nitric oxide synthase 29
aquaporin 28
p40 28
MDC 28
monocyte chemotactic protein 1 28
CCL1 28
matrix metalloproteinase 28
thymus 27
C-reactive protein 27
fibronectin 27
AP-1 27
interferon gamma 26
MHC 26
EPA 26
CD25 25
RANKL 25
EGF 25
IL-23 25
membrane protein 24
IL-1RA 24
RNase 24
CD69 24
p70 24
mast cell 23
INF 23
MCP-4 23
lactate dehydrogenase 23
more...
Disease
MIP 4876
tumor 235
HIV 202
cancer 197
sepsis 101
sepsis 98
ischemia 75
pneumonia 75
immunodeficiency 72
infectious diseases 65
asthma 64
influenza 58
AIDS 55
virus infection 55
rheumatoid arthritis 54
diabetes 53
SEM 52
arthritis 48
tuberculosis 47
chronic obstructive pulmonary disease 46
multiple sclerosis 45
Mycobacterium 45
Infection 44
tumor growth 43
leukemia 41
obesity 38
carcinoma 38
colitis 37
CCL 36
cornea 35
multiple myeloma 35
pertussis 34
Alzheimer's disease 33
inflammatory bowel disease 33
encephalomyelitis 33
breast cancer 32
peritonitis 31
pulmonary edema 30
stroke 30
bacterial infection 29
melanoma 28
atherosclerosis 27
cataract 27
malaria 26
lung cancer 25
plaque 25
lung disease 24
lymphoma 23
colorectal cancer 22
keratitis 21
metastases 21
Klebsiella 20
viremia 20
herpes simplex 19
tumor progression 19
cold 19
GSH 19
cardiovascular disease 19
depression 18
tumorigenesis 18
cystic fibrosis 18
dengue 18
meningitis 17
prostate cancer 17
Blocking 16
cytomegalovirus 16
LIP 16
Chlamydia 15
hepatocellular carcinoma 15
autoimmune disease 15
glomerulonephritis 15
COPD 15
HGF 15
hypertension 15
periodontitis 14
bone disease 14
hepatitis C 14
immunopathology 14
chronic myeloid leukemia 14
adenocarcinoma 14
RSV infection 14
type 1 diabetes 14
liver disease 14
AIP 13
gastritis 13
AIP 13
SDS 13
SCID 13
heart failure 13
bacterial pneumonia 13
pulmonary fibrosis 13
thrombocytopenia 12
adenoma 12
TEM 12
Kaposi's sarcoma 12
type 2 diabetes 12
eosinophilia 12
carcinogenesis 12
systemic lupus erythematosus 12
hyperglycemia 12
dementia 12
candidiasis 12
renal ischemia 11
respiratory failure 11
TEM 11
colon cancer 11
malnutrition 11
EDA 11
acute myeloid leukemia 11
neutropenia 11
emphysema 11
cerebral ischemia 11
idiopathic pulmonary fibrosis 11
Schistosoma mansoni 10
myocardial infarction 10
ash 10
myocardial ischemia 10
PSS 10
Mycoplasma 10
proteinuria 10
Crohn's disease 10
atopic dermatitis 10
pulmonary tuberculosis 10
adult respiratory distress syndrome 10
non-small cell lung cancer 10
anemia 10
bacteremia 10
bacterial meningitis 9
osteoarthritis 9
fungal infection 9
aspergillosis 9
ulcerative colitis 9
chronic hepatitis 9
hemorrhagic fever 9
hepatitis 9
NOD 9
respiratory disease 9
lymphopenia 9
lung carcinoma 9
Legionella 9
leishmaniasis 9
psoriasis 9
DBA 9
cholera 9
uterus 8
renal disease 8
myocarditis 8
allergic rhinitis 8
cirrhosis 8
SARS 8
acute pancreatitis 8
squamous cell carcinoma 8
Haemophilus 8
nephritis 8
bronchiolitis 8
avian influenza 8
TAM 7
chronic pancreatitis 7
ICP 7
APC 7
more...
Symptom
pain 43
respiratory distress 27
fatigue 19
weakness 16
functional recovery 14
dyspnea 13
hyperoxia 11
anesthesia 10
POA 10
hypothermia 10
cough 8
exhaustion 7
erythema 7
diarrhea 6
collapse 5
vomiting 5
wheezing 4
overweight 4
analgesia 4
headache 4
splenomegaly 4
seizures 4
HSA 4
dry eye 3
ataxia 3
arthralgia 3
tremor 3
hypercapnia 3
bone pain 2
sneezing 2
abdominal pain 2
chills 2
exertional dyspnea 2
low back pain 2
nausea 2
Ill 2
myalgia 2
anorexia 2
thinning 2
Gasping 1
sleepiness 1
limb pain 1
hyperesthesia 1
Postoperative pain 1
memory loss 1
paresis 1
vertigo 1
adipsia 1
polyuria 1
Respiratory symptoms 1
Neuropathic pain 1
cachexia 1
flank pain 1
Wind 1
flushing 1
microbial colonization 1
tachypnea 1
Ear swelling 1
cardiovascular disability 1
stigma 1
hypotonia 1
blurred vision 1
discomfort 1
spasticity 1
alexithymia 1
starvation 1
orthopnea 1
CSR 1
pelvic pain 1
syncope 1
dry skin 1
itchy nose 1
epigastric pain 1
rhinorrhea 1
neurological disability 1
shortness of breath 1
Moderate pain 1
nausea and vomiting 1
agitation 1
numbness 1
constipation 1
back pain 1
Depressive symptoms 1
discomfort 1
chronic cough 1
ataxic gait 1
Drug
CSF 256
IL-2 205
IFN-gamma 160
G-CSF 132
IL-1ra 39
CCL 36
Dermatol 25
ROS 23
MAP 16
SiO2 15
IL-11 15
lysine 12
IFN-beta 11
CTA 9
TiO2 9
caffeine 9
Asthma 9
ROC 9
Asn 7
PTH 7
CEC 5
ascorbate 5
Leaf 5
Monit 5
p75 5
Cardiovasc 5
PMPA 5
BTC 5
KGF 4
ZnO 4
Lovastatin 4
DFP 4
Glycerol 4
DEX 4
CTX 4
GEO 4
Bifidobacterium 4
EE2 4
CPR 4
Albumin 4
Kenyan 3
Gelatin 3
Silica 3
TAK 3
vitamin E 3
MOF 3
Infliximab 2
Dextrose 2
CTX 2
L-tyrosine 2
NADH 2
Taxol 2
Indomethacin 2
Histamine 2
AZT 2
Pirfenidone 2
VCR 2
DNase I 2
Infliximab 2
AZT 2
lactose 2
Ringer's solution 2
uPA 2
Nephron 2
CTX 2
Oxaliplatin 2
Theophylline 2
Heme 2
Anakinra 2
ENT 2
PTC 2
Fragment 2
ampicillin 2
Activin 2
Fluorescein 2
DM1 2
Ethanol 2
Biopolymers 2
Etoposide 1
Myozyme 1
TTC 1
Omniscan 1
FAD 1
Tocilizumab 1
SBT 1
Meropenem 1
E5564 1
Gel 1
Artesunate 1
Roflumilast 1
Simvastatin 1
NOV 1
Cidofovir 1
MIL 1
RFP 1
Iopamidol 1
PMEA 1
Sulprostone 1
Pepstatin 1
Omalizumab 1
Atenolol 1
CTT 1
CTC 1
Ortho Tri-Cyclen 1
Angiotensin II 1
Adriamycin 1
NAG 1
Ranitidine 1
Itraconazole 1
Meth 1
Glycyrrhiza 1
TAT 1
PE2 1
Peridinin 1
Prednisone 1
Rebamipide 1
Roflumilast 1
ISP 1
Fluticasone propionate 1
Timolol 1
ABC 1
MTC 1
BLM 1
EPA 1
DEL 1
Portal 1
citric acid 1
Zoledronic acid 1
AraC 1
Propionamide 1
Allergen 1
THF 1
Fondaparinux 1
Iomeprol 1
Clodronate 1
Butaprost 1
Cibacron Blue 1
Olmesartan 1
Spectrum 1
Ergosterol 1
Bupivacaine 1
Dial 1
Fenoterol 1
ADM 1
OTC 1
Alanine 1
TEL 1
Lenalidomide 1
Lipiodol 1
Spectrum 1
CAM 1
Enfuvirtide 1
Vinpocetine 1
CTC 1
Luteinizing 1
Dextran sulfate sodium 1
Rutin 1
Aprotinin 1
DPA 1
Frontal 1
more...
Enzyme
MIP 4906
mitogen-activated protein kinase 200
peroxidase 131
ERK 90
proteasome 53
reverse transcriptase 41
alanine aminotransferase 40
RNase 34
RNase 32
lysozyme 29
superoxide dismutase 28
protein kinase 28
lactate dehydrogenase 27
protein kinase C 26
luciferase 26
aspartate aminotransferase 25
collagenase 25
catalase 22
caspase-3 22
MEK 22
ACS 21
NO synthase 21
BAL 18
focal adhesion kinase 17
AST 16
MPP 15
MAP 14
IKK 14
PARP 13
trypsin 13
elastase 12
NADPH oxidase 11
APC 11
granzyme B 11
neutrophil elastase 10
NADPH oxidase 10
caspase-1 9
prostate-specific membrane antigen 8
MMP-3 8
alkaline phosphatase 8
AMP-activated protein kinase 8
ribonuclease 8
creatine kinase 8
phospholipase C 8
ribonuclease 8
ATPase 7
thrombin 7
NOS 7
phosphatidylinositol 3-kinase 7
TSP-1 7
MMP 6
matrix metalloproteinase 9 6
tissue plasminogen activator 6
arginase 6
CPR 6
glutathione peroxidase 6
AMPK 6
phosphodiesterase 5
MEKK1 5
hexosaminidase 5
heme oxygenase 5
acid phosphatase 5
urokinase-type plasminogen activator 5
ornithine transcarbamylase 5
beta-galactosidase 5
acetylcholinesterase 4
adenosine deaminase 4
matrix metalloproteinase 2 4
lipase 4
MAT 4
calcineurin 4
SPC 4
adenylate cyclase 4
MAT 4
adenosine deaminase 4
cholinesterase 4
lipoxygenase 3
neuropathy target esterase 3
ACE 3
GRK5 3
interstitial collagenase 3
glucose oxidase 3
chymotrypsin 3
aldehyde dehydrogenase 3
hypoxanthine-guanine phosphoribosyltransferase 3
cathepsin K 3
AMPK 3
CD10 3
FAST 3
malate dehydrogenase 3
pepsin 3
complex I 3
thymidine kinase 3
beta-glucuronidase 3
hyaluronidase 3
dihydrofolate reductase 3
chloramphenicol acetyltransferase 3
thyroid peroxidase 3
caspase-8 3
DNA polymerase 3
RNA polymerase 3
MDP 3
chymase 2
GRK2 2
tyrosinase 2
papain 2
phospholipase A2 2
factor D 2
ribonucleotide reductase 2
phosphoinositide 3-kinase 2
GSK 2
glutathione S-transferase 2
xanthine oxidase 2
ceruloplasmin 2
carboxypeptidase E 2
ribonucleotide reductase 2
gamma-glutamyl transpeptidase 2
glutathione reductase 2
protein phosphatase 2A 2
glucose-6-phosphate dehydrogenase 2
myo-inositol-1-phosphate synthase 2
15-lipoxygenase 2
prolyl hydroxylase 2
DNase 2
enolase 2
cathepsin G 2
glucocerebrosidase 2
hyaluronidase 2
S1 nuclease 2
endonuclease 2
tyrosine hydroxylase 2
CYP3A4 2
ATP synthase 2
caspase-9 2
dipeptidyl peptidase IV 2
diaphorase 2
neuraminidase 2
apyrase 2
CFI 1
DNA ligase 1
DNA ligase 1
PRT 1
granzyme K 1
Thy1 1
indoleamine 2,3-dioxygenase 1
chondroitinase 1
CAD 1
heparinase 1
CAD 1
DNA methyltransferase 1
arylsulfatase A 1
glutamate dehydrogenase 1
PHD 1
TPP 1
CaMKII 1
cathepsin B 1
C3 convertase 1
ADP-ribosyltransferase 1
myosin light chain kinase 1
glutamate dehydrogenase 1
more...
Compound
TNF 762
Dec 324
water 283
DNA 195
Clin 148
calcium 124
oxygen 121
nitric oxide 93
PEG 85
PEG 81
sodium 64
glucose 64
THP 63
THP 63
MEP 58
MEP 58
phosphate 53
MCP 49
hydrogen 47
iron 46
tyrosine 43
methanol 43
ethanol 42
acrylamide 42
urea 39
glycerol 37
nitrogen 36
sulfate 35
cysteine 32
acetonitrile 32
Phe 31
acetate 31
PMA 28
PMA 27
cAMP 27
4-vinylpyridine 27
lysine 27
creatinine 26
vinyl 26
alanine 24
arginine 24
zinc 23
MDA 23
ACS 22
leucine 22
ammonium 22
acetic acid 22
salt 22
tryptophan 21
ACS 21
galactose 21
toluene 21
PGE 21
TOF 20
BAL 19
GSH 19
GSH 19
methionine 18
His 18
PGE2 17
NH2 17
titanium 17
Asp 17
SiO2 17
copper 16
N-acetylcysteine 16
NKT 16
tryptophan 16
tryptophan 16
tryptophan 16
H2O2 15
ATP 15
MAP 15
serine 14
CO2 14
thioglycollate 13
silver 13
SDS 13
TEM 12
Dexamethasone 12
TCA 12
MTT 12
iodine 12
bromide 11
mercury 11
DBA 11
phenol 11
chloroform 10
nickel 10
glutamate 10
pyridine 10
hydroxide 10
POA 10
caffeine 9
silicon 9
potassium 9
HCl 9
BCG 9
Gly 9
DBA 9
AMP 9
DBA 9
MEK 9
nitrate 9
CHIP 9
2-hydroxyethyl 8
ADP 8
hexane 8
2-hydroxyethyl 8
Cardiol 8
2-hydroxyethyl 8
NPA 8
2,4-D 8
EDTA 8
EDTA 8
vitamin D 8
2-hydroxyethyl 8
2-hydroxyethyl 8
proline 8
glutamic acid 8
2-hydroxyethyl 8
aluminum 8
2-hydroxyethyl 8
2-hydroxyethyl 8
DMSO 7
Quercetin 7
cobalt 7
DSS 7
MMA 7
Cholesterol 7
manganese 7
acrylic acid 7
GTP 7
MMA 7
prostaglandin E1 7
SSD 7
ADP 6
isopropanol 6
acetone 6
threonine 6
cadmium 6
APAP 6
BCR 6
ADP 6
TPA 6
dichloromethane 6
ALP 6
Curcumin 6
CAM 6
TPA 6
5-HT 5
Bisphenol A 5
DTPA 5
MPP 5
chromium 5
retinoic acid 5
butyric acid 5
DMA 5
6-12 5
5-methylisophthalic acid 5
more...