Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.59 (
MIP
)
4,906
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Antibiotics without selectivity for acne treatment may destroy the beneficial microbes in the human microbiome that helps to fight Cutibacterium acnes (C. acnes), a bacterium associated with inflammatory acne vulgaris. Probiotic treatment by direct application of live
Staphylococcus epidermidis
(
S. epidermidis
) onto the open acne lesions may run the risk of bloodstream infections. Here, we fabricated the polysulfone microtube array membranes (PSF MTAM) to encapsulate probiotic
S.
epidermidis.
We demonstrate that the application of the encapsulation of
S.
epidermidis
in PSF MTAM enhanced the glycerol fermentation activities of
S. epidermidis.
To mimic the granulomatous type of acne inflammatory acne vulgaris, the ears of mice were injected intradermally with
C
.
acnes
to induce the secretion of macrophage inflammatory protein-2 (MIP-2), a murine counterpart of human interleukin (IL)-8. The C. acnes-injected mouse ears were covered with a
PST
MTAM encapsulated with or without
S.
epidermidis
in the presence of glycerol. The application of
S.
epidermidis
-encapsulated
PST
MTAM plus glycerol onto the
C
.
acnes
-injected mouse ears considerably reduced the growth of
C
. acnes
and the production of
MIP
-2. Furthermore, no
S. epidermidis
leaked from PSF MTAM into mouse skin. The
S. epidermidis
-encapsulated
PST
MTAM functions as a probiotic acne patch.
...
PMID:A Microtube Array Membrane (MTAM) Encapsulated Live Fermenting Staphylococcus epidermidis as a Skin Probiotic Patch against Cutibacterium acnes. 3057 30
