Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.56 (insulin-degrading enzyme)
 737 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin-degrading enzyme 632
insulin 309
neutral endopeptidase 105
amyloid precursor protein 96
insulinase 58
amyloid beta 47
Mol 44
APP 40
Sep 37
insulysin 35
insulin receptor 33
BACE1 30
glucagon 30
PS1 28
metalloprotease 27
proteasome 25
ATP 22
A14 21
HHEX 20
peptidase 18
MGC 16
metalloendopeptidase 15
amylin 12
glycoprotein 12
apolipoprotein E 11
ubiquitin 11
TNF 11
APOE 10
NEP 10
SDS 10
polypeptide 10
metallopeptidase 10
CDKAL1 10
glial fibrillary acidic protein 9
TCF7L2 8
endoplasmic reticulum 8
ADAM10 8
BACE 8
B17 8
IRS-1 8
SLC30A8 8
tumor necrosis factor 8
precursor protein 8
beta-endorphin 8
PreP 7
glutathione-insulin transhydrogenase 7
brain-derived neurotrophic factor 7
insulin-like growth factor 7
proinsulin 7
B10 7
membrane-bound 7
RAGE 6
KSP 6
amyloid protein 6
p38 6
synuclein 6
metalloproteinase 6
peroxisome proliferator-activated receptor gamma 6
A15 6
cathepsin D 6
tyrosine kinase 6
cathepsin B 6
matrix metalloproteinase 5
PI3K 5
ACE 5
ECE-1 5
TCA 5
PLAU 5
transthyretin 5
presenilin 1 5
peroxisome proliferator-activated receptor 5
protease inhibitor 5
fused 5
trypsin inhibitor 5
ACS 5
cytokine 5
cysteine protease 5
transforming growth factor-alpha 5
epidermal growth factor 5
extracellular signal-regulated kinase 5
more...
Disease
Alzheimer's disease 273
diabetes 89
type 2 diabetes 53
plaque 31
cognitive impairment 27
dementia 27
hyperinsulinemia 18
obesity 13
tumor 12
glucose intolerance 11
cancer 10
neuroblastoma 10
SDS 10
memory impairment 10
hypertension 9
hepatocellular carcinoma 8
varicella 8
hyperglycemia 7
INS 7
stroke 6
Parkinson's disease 6
vascular disease 6
hypoglycemia 5
ischemia 5
HIV 5
anemia 4
amyloidosis 4
breast cancer 4
Down syndrome 4
metabolic syndrome 4
cold 3
DM2 3
insulinoma 3
APC 3
virus infection 3
tuberculosis 3
cerebral ischemia 3
iron deficiency 3
retinoblastoma 3
cirrhosis 3
tumorigenesis 3
melanoma 3
herpes simplex 2
Evans 2
LDLR 2
carcinoma 2
Lyme disease 2
dyslipidemia 2
acne 2
Mycobacterium 2
Yersinia 2
West 2
hypercholesterolemia 2
PAM 2
gallstones 2
degenerative disc disease 2
type 1 diabetes 2
macular degeneration 2
diabetic retinopathy 2
skin disease 2
PCS 1
mental retardation 1
herpes 1
corneal dystrophy 1
cognitive disorder 1
hepatitis C 1
primary tumor 1
GSH 1
TBS 1
PNET 1
EDA 1
STS 1
acute myeloid leukemia 1
ash 1
PDB 1
myeloid leukemia 1
hyperhomocysteinemia 1
HLA-B27 1
herpes zoster 1
infectious diseases 1
more...
Symptom
memory loss 4
anesthesia 2
functional recovery 1
anorexia 1
arm pain 1
Decreased activity 1
diarrhea 1
Drug
Gel 5
CSF 4
Glucagon 4
ADM 3
Activin 3
Dermatol 3
Aprotinin 2
uPA 2
DMI 1
Apomorphine 1
Perindopril 1
Idebenone 1
Ginseng 1
Fructose 1
Donepezil 1
ALA 1
Poudre 1
CTA 1
Imatinib 1
CaCl2 1
Glutathione 1
Glycerol 1
Meth 1
DNase I 1
MTC 1
lysine 1
Asn 1
ZnCl2 1
Alanine 1
Nephron 1
Ammonium chloride 1
Liraglutide 1
ZnCl2 1
ABC 1
MAP 1
Cardiovasc 1
Lead acetate 1
Gleevec 1
ascorbate 1
Calcium chloride 1
EE2 1
FAD 1
ROS 1
Spectrum 1
Parkin 1
Parkin 1
Vitamin E 1
Urso 1
Spectrum 1
IL-2 1
DEL 1
Enzyme
insulin-degrading enzyme 737
CD10 118
proteasome 28
endothelin-converting enzyme 21
protein kinase 16
ERK 15
PTR 13
plasmin 13
mitogen-activated protein kinase 12
trypsin 8
beta-secretase 8
glutathione-insulin transhydrogenase 8
nardilysin 7
ACE 7
cathepsin B 6
cathepsin D 6
acetylcholinesterase 6
ACS 5
thermolysin 5
GSK 5
lysozyme 4
MPP 4
protein kinase C 4
APC 4
transhydrogenase 4
ATPase 4
thimet oligopeptidase 3
urokinase-type plasminogen activator 3
furin 3
AMP-activated protein kinase 3
RNase 3
cholinesterase 3
chymotrypsin 3
RNase 3
AMPK 3
catalase 3
tissue plasminogen activator 2
glucose oxidase 2
MMP-3 2
superoxide dismutase 2
PAM 2
caspase-3 2
renin 2
TPP 2
cathepsin L 2
AMPK 2
PTPase 2
neurolysin 2
lactate dehydrogenase 2
glutathione peroxidase 2
subtilisin 1
TOR 1
proteinase K 1
NADH pyrophosphatase 1
caspase-8 1
focal adhesion kinase 1
IDS3 1
beta-glucuronidase 1
phosphodiesterase 1
neuraminidase 1
aldolase 1
prostate-specific membrane antigen 1
IDS2 1
hexokinase 1
diaphorase 1
KLK7 1
NADPH oxidase 1
choline acetyltransferase 1
CaMKII 1
prostate-specific antigen 1
caspase-9 1
malate dehydrogenase 1
endoproteinase Glu-C 1
NADPH oxidase 1
PNGase F 1
ribonuclease 1
cdc2 1
prolyl endopeptidase 1
complex I 1
apyrase 1
more...
Compound
Insulin 71
glucose 71
Dec 55
zinc 34
water 33
tyrosine 27
ATP 22
Clin 21
leucine 20
DNA 19
TCA 19
Phe 18
serine 16
sodium 12
His 12
TNF 11
sulfate 11
SDS 11
EDTA 11
EDTA 11
alanine 11
Asp 9
ammonium 9
calcium 9
arginine 9
manganese 8
B17 8
phosphate 8
lysine 8
methionine 7
oxygen 7
acetate 6
iron 6
nitric oxide 6
aluminum 6
cysteine 6
Bacitracin 5
copper 5
ACS 5
glutamate 5
threonine 5
valine 5
ACS 5
cobalt 4
DEAE 4
galactose 4
NH2 4
Glucagon 4
salt 4
AMP 4
proline 4
COS 4
aspartic acid 4
aspartic acid 3
hydrogen 3
palmitic acid 3
chromium 3
Diabetol 3
Wellcome 3
Diabetol 3
aspartic acid 3
glutamine 3
STZ 3
aspartic acid 3
Ile 3
Congo red 3
IDA 3
ADP 3
cadmium 2
formic acid 2
formic acid 2
urea 2
ADP 2
Chloroquine 2
formic acid 2
Lead 2
ADP 2
PAM 2
MTT 2
mercury 2
more...