Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.56 (insulin-degrading enzyme)
 737 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin-degrading enzyme 0.759
insulinase 0.076
insulysin 0.047
HHEX 0.005
neutral endopeptidase 0.004
PreP 0.002
hNRD2 0.002
A14 0.001
CDKAL1 0.001
NRDC 0.001
alphaT-catenin 0.001
myosin XVI 0.001
SLC30A8 0.001
nardilysin 0.001
amyloid precursor protein 0.001
glutathione-insulin transhydrogenase 0.001
insulin 0.001
PPP1R5 0.001
amyloid beta 0.001
metalloendopeptidase 0.001
BACE1 0.001
APP 0.000
UBE2J1 0.000
LRRTM3 0.000
PS1 0.000
ECE-2 0.000
vesicle trafficking protein 0.000
SORCS1 0.000
MYO16 0.000
kuzbanian 0.000
APBB2 0.000
VPS26A 0.000
IGF2BP2 0.000
MGC 0.000
ECE2 0.000
gene/pseudogene 0.000
PLAU 0.000
NADH pyrophosphatase 0.000
NEP 0.000
M-BAR 0.000
ECE-1 0.000
GABRE 0.000
Nardilysin 0.000
CAMK1D 0.000
flotillin 1 0.000
phosphatidylinositol binding clathrin assembly protein 0.000
metalloprotease 0.000
KSP 0.000
TCF7L2 0.000
PPARGC1 0.000
B17 0.000
metalloprotease 1 0.000
N-arginine dibasic convertase 0.000
ADDL 0.000
ARAP1 0.000
TCF2 0.000
WNT8B 0.000
TFCP2 0.000
EIF2S1 0.000
SEC22B 0.000
metallopeptidase 0.000
CALHM1 0.000
ITM2B 0.000
Golgi reassembly stacking protein 0.000
insulin receptor 0.000
neurolysin 0.000
BACE 0.000
IFI-56K 0.000
MCJ 0.000
TRIM16 0.000
USP11 0.000
DPYSL2 0.000
NEP2 0.000
GAPDS 0.000
ADAM10 0.000
A15 0.000
CDKN3 0.000
zinc metalloendopeptidase 0.000
beta-site APP-cleaving enzyme 1 0.000
ECE1 0.000
ADAMTS9 0.000
TSPAN8 0.000
POU2F1 0.000
VRL-1 0.000
ECE 0.000
LRP2 0.000
LRP1 0.000
tripeptidyl peptidase II 0.000
PLB1 0.000
IRX3 0.000
Nicastrin 0.000
MTTP 0.000
KLF14 0.000
ABCG4 0.000
ALX4 0.000
WFS1 0.000
kallikrein 7 0.000
p82 0.000
amylin 0.000
SREBF2 0.000
PEN2 0.000
CALM1 0.000
PIK3CB 0.000
TNFRSF6 0.000
PSEN1 0.000
Cables 0.000
GCK 0.000
macrophage receptor with collagenous structure 0.000
PTIP 0.000
B14 0.000
Grb14 0.000
carcinoembryonic antigen-related cell adhesion molecule 1 0.000
CHRNB2 0.000
GOT1 0.000
APOE 0.000
GGA3 0.000
NEP1 0.000
VRK1 0.000
nicastrin 0.000
ZIP14 0.000
GRIN1 0.000
SLC2A2 0.000
peptidase 0.000
BRI 0.000
HSPG2 0.000
glucagon 0.000
PMP70 0.000
fat mass and obesity associated 0.000
zinc metallopeptidase 0.000
amyloid protein 0.000
NPFF 0.000
MTNR1B 0.000
nuclear respiratory factor 1 0.000
alpha-tocopherol transfer protein 0.000
RAGE 0.000
NTE 0.000
CDK5 0.000
presenilin 1 0.000
CYBA 0.000
JAZF1 0.000
B28 0.000
aspartyl protease 0.000
insulin-regulated aminopeptidase 0.000
PIK3CD 0.000
cyclin-dependent kinase inhibitor 2A 0.000
cGMP-PDE 0.000
glutamate carboxypeptidase II 0.000
insulin receptor substrate-2 0.000
Transforming growth factor alpha 0.000
SORL1 0.000
Fe65 0.000
BCL2-associated X protein 0.000
LGR5 0.000
proteasome 0.000
RBP4 0.000
transforming growth factor-alpha 0.000
B13 0.000
receptor for activated C kinase 1 0.000
zinc-binding protein 0.000
GCKR 0.000
GSTM3 0.000
ADRA2A 0.000
IL-34 0.000
TIM23 0.000
MME 0.000
IDA 0.000
aminopeptidase B 0.000
PICALM 0.000
EXT2 0.000
GIT 0.000
apolipoprotein E 0.000
heterogeneous nuclear ribonucleoprotein K 0.000
Neutral endopeptidase 0.000
TA3 0.000
glycogen synthase kinase 3 beta 0.000
FTO 0.000
putative oncogene 0.000
MP1 0.000
endoprotease 0.000
B22 0.000
Eg5 0.000
NMDAR1 0.000
ENPP1 0.000
DM2 0.000
IRS-1 0.000
GRIN2B 0.000
INSR 0.000
apolipoprotein J 0.000
PSEN2 0.000
E2 ubiquitin-conjugating enzyme 0.000
precursor protein 0.000
memapsin 2 0.000
CDC6 0.000
NRF-1 0.000
CDKN2B 0.000
phosphotyrosine phosphatase 0.000
rat homolog 0.000
GTPase Ran 0.000
insulin-like growth factor 2 0.000
zinc transporter 0.000
SOX4 0.000
B10 0.000
APOA1 0.000
ENO1 0.000
Kir6.2 0.000
proinsulin 0.000
IRAK4 0.000
SOD3 0.000
NeuroD 0.000
cathepsin E 0.000
NPR-C 0.000
NPB 0.000
Smad6 0.000
GSL 0.000
cyclin-dependent kinase 5 0.000
macrophage scavenger receptor 0.000
Cyclin-dependent kinase 5 0.000
transcription factor 7-like 2 0.000
TREM2 0.000
mannose-6-phosphate receptor 0.000
HEX 0.000
ACT1 0.000
CCL18 0.000
B29 0.000
IRS2 0.000
AURKA 0.000
ASH 0.000
cathepsin B 0.000
complement receptor 1 0.000
fructose 1,6-bisphosphatase 0.000
TDT 0.000
endosomal protein 0.000
Tumor suppressor 0.000
STX 0.000
Tip60 0.000
Drosophila) 0.000
PAX2 0.000
Fractalkine 0.000
cathepsin D 0.000
beclin 1 0.000
APOB 0.000
Gag polyprotein 0.000
prolyl oligopeptidase 0.000
OPS 0.000
20 copies 0.000
S1P2 0.000
ASI 0.000
IRS-2 0.000
transthyretin 0.000
apoptosis-related protein 0.000
GCLC 0.000
Aurora-B 0.000
UPS 0.000
TfR 0.000
chymotrypsin-like 0.000
endocytic receptor 0.000
CASP 0.000
preproinsulin 0.000
LRP 0.000
MAGE 0.000
Apolipoprotein E 0.000
synuclein 0.000
CLN2 0.000
FPR2 0.000
sequestosome 1 0.000
formyl peptide receptor 0.000
Metalloproteinase 0.000
ESP 0.000
RIN 0.000
LAMP-1 0.000
TBS 0.000
cannabinoid receptor 1 0.000
CMK 0.000
ionized calcium-binding adapter molecule 0.000
C-type natriuretic peptide 0.000
LDLR 0.000
MHC class I antigen 0.000
cysteine protease 0.000
IGFBP3 0.000
MTC 0.000
CASP3 0.000
precursor peptide 0.000
RAC1 0.000
Thrombomodulin 0.000
p32 0.000
CTF 0.000
TCA 0.000
expressed in testis 0.000
AKT2 0.000
tPA 0.000
TAU 0.000
cytochrome bc1 0.000
profilin 0.000
CDC2 0.000
trypsin inhibitor 0.000
GTT 0.000
ATP-binding cassette transporter A1 0.000
NL4 0.000
peroxisome proliferator-activated receptor gamma 0.000
differentially expressed protein 0.000
aquaporin 4 0.000
CAF 0.000
PRNP 0.000
Insulin receptor 0.000
B15 0.000
metalloproteinase 0.000
PSD-95 0.000
mouse homolog 0.000
CYP2C 0.000
Choline acetyltransferase 0.000
IRF 0.000
low-density lipoprotein receptor 0.000
CDKN2A 0.000
glial fibrillary acidic protein 0.000
dynorphin 0.000
TRPM8 0.000
PPARG 0.000
NT-4/5 0.000
choline kinase 0.000
PACAP 0.000
more...
Disease
Alzheimer's disease 0.001
Cerebrovascular amyloidosis 0.001
Sporadic cerebral amyloid angiopathy 0.000
type 2 diabetes 0.000
INS 0.000
Advanced cancer 0.000
hyperinsulinemia 0.000
diabetes 0.000
Neurodegenerative Disorders 0.000
cognitive impairment 0.000
EXT2 0.000
plaque 0.000
DM2 0.000
memory impairment 0.000
APOA1 0.000
dementia 0.000
BED 0.000
glucose intolerance 0.000
biventricular failure 0.000
APOB 0.000
varicella 0.000
degenerative disc disease 0.000
denticles 0.000
LDLR 0.000
cognitive disorder 0.000
TBS 0.000
MTC 0.000
Habituation 0.000
corneal dystrophy 0.000
PNET 0.000
PCS 0.000
PAM 0.000
cowpox 0.000
tinea capitis 0.000
neuroblastoma 0.000
insulinoma 0.000
DMS 0.000
Testis 0.000
Testis 0.000
diabetic foot ulcers 0.000
Johne's disease 0.000
cholecystolithiasis 0.000
skin infection 0.000
vascular disease 0.000
senile dementia 0.000
Dementia with Lewy bodies 0.000
SDS 0.000
coccidiosis 0.000
spinal stenosis 0.000
Fibrillation 0.000
iron deficiency 0.000
Dependence 0.000
hyperglycemia 0.000
Albert 0.000
amyloidosis 0.000
ICS 0.000
gestational trophoblastic disease 0.000
EDA 0.000
lipodystrophy 0.000
Down syndrome 0.000
HLA-B27 0.000
hypoglycemia 0.000
biliary obstruction 0.000
STS 0.000
social stress 0.000
radiculopathy 0.000
obesity 0.000
APC 0.000
acne vulgaris 0.000
brain dysfunction 0.000
retinoblastoma 0.000
ACP 0.000
acne 0.000
AAA 0.000
Recruitment 0.000
macular degeneration 0.000
Lyme disease 0.000
hyperhomocysteinemia 0.000
hepatocellular carcinoma 0.000
IBM 0.000
cholecystitis 0.000
diabetic retinopathy 0.000
metabolic syndrome 0.000
immunopathology 0.000
myeloid leukemia 0.000
cerebral ischemia 0.000
Yersinia 0.000
immaturity 0.000
Prostate Cancer 0.000
thymoma 0.000
Disorder 0.000
gallstones 0.000
neoplastic transformation 0.000
metabolic disorder 0.000
herpes zoster 0.000
Parkinson's disease 0.000
retinitis pigmentosa 0.000
Evans 0.000
amnesia 0.000
skin disease 0.000
eczema 0.000
muscular dystrophy 0.000
dyslipidemia 0.000
urticaria 0.000
hypercholesterolemia 0.000
PDB 0.000
hypertension 0.000
wasting 0.000
Cryptococcus neoformans 0.000
anemia 0.000
herpes 0.000
abdominal aortic aneurysm 0.000
Still 0.000
Blocking 0.000
type 1 diabetes 0.000
Steroids 0.000
gastritis 0.000
ischemia 0.000
cirrhosis 0.000
myopathy 0.000
stroke 0.000
brain tumor 0.000
virus infection 0.000
herpes simplex 0.000
Huntington's disease 0.000
Autism 0.000
fatty liver 0.000
myelopathy 0.000
tumorigenesis 0.000
pheochromocytoma 0.000
ash 0.000
mental retardation 0.000
mental retardation 0.000
tumor 0.000
migraine 0.000
melanoma 0.000
HIV 0.000
amyotrophic lateral sclerosis 0.000
tuberculosis 0.000
pertussis 0.000
primary tumor 0.000
TEM 0.000
meningitis 0.000
TEM 0.000
chronic renal failure 0.000
cold 0.000
Mycobacterium 0.000
cornea 0.000
dehydration 0.000
breast cancer 0.000
sarcoma 0.000
addiction 0.000
ovarian cancer 0.000
MCF 0.000
malnutrition 0.000
liver disease 0.000
fits 0.000
autism 0.000
West 0.000
uterus 0.000
hepatitis C 0.000
acute myeloid leukemia 0.000
cancer 0.000
multiple myeloma 0.000
GSH 0.000
tumor progression 0.000
malaria 0.000
tumor growth 0.000
prostate cancer 0.000
cardiovascular disease 0.000
carcinoma 0.000
adenocarcinoma 0.000
immunodeficiency 0.000
lung cancer 0.000
heart failure 0.000
lymphoma 0.000
infectious diseases 0.000
AIDS 0.000
depression 0.000
Symptom
arm pain 0.000
Decreased activity 0.000
memory loss 0.000
functional recovery 0.000
anorexia 0.000
anesthesia 0.000
diarrhea 0.000
Drug
Urso 0.000
Poudre 0.000
Idebenone 0.000
Lead acetate 0.000
Calcium chloride 0.000
Ammonium chloride 0.000
Perindopril 0.000
DEL 0.000
Aprotinin 0.000
Activin 0.000
Liraglutide 0.000
MTC 0.000
Donepezil 0.000
Glucagon 0.000
ADM 0.000
uPA 0.000
Apomorphine 0.000
ZnCl2 0.000
ZnCl2 0.000
Meth 0.000
CTA 0.000
Gleevec 0.000
Ginseng 0.000
Gel 0.000
Parkin 0.000
Parkin 0.000
Fructose 0.000
DMI 0.000
Glycerol 0.000
Imatinib 0.000
Alanine 0.000
ALA 0.000
Vitamin E 0.000
Spectrum 0.000
CSF 0.000
Glutathione 0.000
FAD 0.000
CaCl2 0.000
EE2 0.000
Spectrum 0.000
DNase I 0.000
ABC 0.000
Asn 0.000
MAP 0.000
Nephron 0.000
ROS 0.000
ascorbate 0.000
IL-2 0.000
lysine 0.000
Dermatol 0.000
Cardiovasc 0.000
Enzyme
insulin-degrading enzyme 0.997
CD10 0.002
EC 3.4.24.54 0.002
glutathione-insulin transhydrogenase 0.002
nardilysin 0.001
endothelin-converting enzyme 0.001
PTR 0.001
IDS3 0.001
IDS2 0.000
NADH pyrophosphatase 0.000
neurolysin 0.000
beta-secretase 0.000
polysaccharide deacetylase 0.000
thimet oligopeptidase 0.000
transhydrogenase 0.000
proteasome 0.000
tripeptidyl peptidase 0.000
KLK7 0.000
plasmin 0.000
thermolysin 0.000
aminopeptidase B 0.000
inositol 3-kinase 0.000
MPP 0.000
cathepsin D 0.000
cathepsin B 0.000
endoproteinase Glu-C 0.000
choline kinase 0.000
PTPase 0.000
lysyl endopeptidase 0.000
TPP 0.000
SMP 0.000
GSK 0.000
fructose 1,6-bisphosphatase 0.000
prolyl endopeptidase 0.000
furin 0.000
PAM 0.000
cathepsin L 0.000
acyl-CoA oxidase 0.000
neuropathy target esterase 0.000
protein kinase 0.000
ACE 0.000
TPP 0.000
TOR 0.000
ERK 0.000
MMP-3 0.000
PNGase F 0.000
apyrase 0.000
phosphoglucose isomerase 0.000
prostate-specific membrane antigen 0.000
trypsin 0.000
HIV-1 protease 0.000
matrix metalloproteinase 9 0.000
mitogen-activated protein kinase 0.000
acetylcholinesterase 0.000
glucose oxidase 0.000
APC 0.000
urokinase-type plasminogen activator 0.000
sialidase 0.000
chymotrypsin 0.000
AMPK 0.000
glucokinase 0.000
acetyl-CoA carboxylase 0.000
AMPK 0.000
cholinesterase 0.000
AMP-activated protein kinase 0.000
lysozyme 0.000
aldolase 0.000
CaMKII 0.000
proteinase K 0.000
RNase 0.000
MMP 0.000
subtilisin 0.000
citrate synthase 0.000
RNase 0.000
malate dehydrogenase 0.000
tissue plasminogen activator 0.000
CPR 0.000
alpha-amylase 0.000
hexokinase 0.000
dihydrofolate reductase 0.000
phosphoinositide 3-kinase 0.000
diaphorase 0.000
choline acetyltransferase 0.000
ribonuclease 0.000
ribonuclease 0.000
caspase-8 0.000
prostate-specific antigen 0.000
MAP 0.000
caspase-9 0.000
beta-glucuronidase 0.000
protein kinase C 0.000
cdc2 0.000
ACS 0.000
complex I 0.000
transcriptase 0.000
glutathione peroxidase 0.000
NADPH oxidase 0.000
ATPase 0.000
phosphatidylinositol 3-kinase 0.000
NADPH oxidase 0.000
lactate dehydrogenase 0.000
P-glycoprotein 0.000
catalase 0.000
neuraminidase 0.000
caspase-3 0.000
renin 0.000
phosphodiesterase 0.000
glutathione S-transferase 0.000
superoxide dismutase 0.000
thrombin 0.000
RNA polymerase 0.000
focal adhesion kinase 0.000
alkaline phosphatase 0.000
peroxidase 0.000
Compound
Pratensein 0.001
X 48 0.000
Insulin 0.000
B17 0.000
Bacitracin 0.000
AFU 0.000
A-14 0.000
Triphosphate 0.000
threonate 0.000
2-butenoic acid 0.000
Geniposide 0.000
1,6-hexanedithiol 0.000
1,6-hexanedithiol 0.000
2-butenoic acid 0.000
TCA 0.000
Thiorphan 0.000
Nelfinavir 0.000
IDA 0.000
Tauroursodeoxycholic acid 0.000
glucose 0.000
Geigy 0.000
DBI 0.000
Digitonin 0.000
Formin 0.000
Leupeptin 0.000
zinc 0.000
Perindopril 0.000
TME 0.000
Hesperidin 0.000
MME 0.000
Leupeptin 0.000
Cotinine 0.000
Pyrroloquinoline quinone 0.000
His-Leu 0.000
TBS 0.000
tyrosine 0.000
Triptolide 0.000
octanoic acid 0.000
MTC 0.000
Wellcome 0.000
[1,10]phenanthroline 0.000
leucine 0.000
APH 0.000
Phe 0.000
CMK 0.000
Glucagon 0.000
Memantine 0.000
Thioflavin T 0.000
EDTA 0.000
EDTA 0.000
Plasmin 0.000
IPA 0.000
Chloroquine 0.000
Chloroquine 0.000
IPA 0.000
IPA 0.000
IPA 0.000
Polypeptide 0.000
serine 0.000
E-64 0.000
STZ 0.000
NEM 0.000
Congo red 0.000
ATP 0.000
MEP 0.000
RU-486 0.000
MEP 0.000
PAM 0.000
Adenine 0.000
MK801 0.000
TPP 0.000
Asp 0.000
tellurium 0.000
Losartan 0.000
SDS 0.000
DMS 0.000
valine 0.000
TNF 0.000
manganese 0.000
MMA 0.000
PAM 0.000
PAM 0.000
2-nonenal 0.000
ubiquinol 0.000
HVA 0.000
MPP 0.000
TPP 0.000
MPP 0.000
Propranolol 0.000
His 0.000
Propranolol 0.000
MSM 0.000
alanine 0.000
Corticosterone 0.000
Fructose 0.000
COS 0.000
aspartic acid 0.000
Diabetol 0.000
FFA 0.000
Bradykinin 0.000
DMI 0.000
DMI 0.000
TPP 0.000
aluminum 0.000
Lidocaine 0.000
water 0.000
Leucine 0.000
DEAE 0.000
HEPES 0.000
palmitic acid 0.000
NTA 0.000
ammonium 0.000
Hematoxylin 0.000
aspartic acid 0.000
aspartic acid 0.000
Ubiquitin 0.000
Capsaicin 0.000
Alanine 0.000
Diabetol 0.000
Dec 0.000
aspartic acid 0.000
AAA 0.000
PAC 0.000
sulfate 0.000
SCC 0.000
trifluoroacetic acid 0.000
trifluoroacetic acid 0.000
trifluoroacetic acid 0.000
trifluoroacetic acid 0.000
Cysteine 0.000
Metformin 0.000
Valproic acid 0.000
trifluoroacetic acid 0.000
Metformin 0.000
methionine 0.000
PDB 0.000
CAP 0.000
Salt 0.000
arginine 0.000
lysine 0.000
guanidine 0.000
Vitamin E 0.000
DHA 0.000
DBP 0.000
ABA 0.000
Lead 0.000
cobalt 0.000
chromium 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
formic acid 0.000
Estrogen 0.000
DHA 0.000
threonine 0.000
MgCl2 0.000
CCl4 0.000
Neuronal 0.000
proline 0.000
Ile 0.000
ABA 0.000
asparagine 0.000
Norepinephrine 0.000
FAD 0.000
pyrrolidine 0.000
Testosterone 0.000
Testosterone 0.000
cysteine 0.000
Estradiol 0.000
adenylate 0.000
CaCl2 0.000
sodium 0.000
Vitamin D 0.000
glutamine 0.000
DHA 0.000
AMP 0.000
Isoproterenol 0.000
Adenosine 0.000
vanadium 0.000
palmitic acid 0.000
acridine 0.000
DMSO 0.000
NH2 0.000
acrylamide 0.000
dUTP 0.000
PMA 0.000
nitric oxide 0.000
glutamate 0.000
DNA 0.000
adenosylmethionine 0.000
ACS 0.000
ACS 0.000
phosphate 0.000
Angiotensin II 0.000
BCG 0.000
Collagen 0.000
Sodium 0.000
MAP 0.000
acetone 0.000
Estrogen 0.000
isopropanol 0.000
acetate 0.000
Cholesterol 0.000
isoleucine 0.000
Tris 0.000
CAM 0.000
phosphoric acid 0.000
copper 0.000
anthracene 0.000
isoleucine 0.000
ADP 0.000
iron 0.000
sodium chloride 0.000
homocysteine 0.000
tin 0.000
galactose 0.000
mercury 0.000
PMA 0.000
hyaluronic acid 0.000
Clin 0.000
calcium 0.000
ethyl acetate 0.000
Cereb 0.000
MTT 0.000
Gly 0.000
cadmium 0.000
acetic acid 0.000
NMDA 0.000
chlorine 0.000
nicotinamide 0.000
ADP 0.000
ADP 0.000
glycerol 0.000
salt 0.000
toluene 0.000
GSH 0.000
GSH 0.000
TOF 0.000
cGMP 0.000
oxygen 0.000
TEM 0.000
MDA 0.000
retinoic acid 0.000
cAMP 0.000
silver 0.000
vitamin D 0.000
Mg2+ 0.000
urea 0.000
nickel 0.000
5-HT 0.000
noradrenaline 0.000
tryptophan 0.000
tryptophan 0.000
tryptophan 0.000
tryptophan 0.000
potassium 0.000
phosphorus 0.000
iodine 0.000
hydrogen 0.000
PEG 0.000
nitrogen 0.000
ethanol 0.000
Cardiol 0.000