Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.56 (insulin-degrading enzyme)
 737 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulysin 15.4
hNRD2 15.4
insulinase 15.4
insulin-degrading enzyme 15.2
myosin XVI 13.4
PreP 13.0
HHEX 12.8
alphaT-catenin 12.7
NRDC 12.7
PPP1R5 12.6
LRRTM3 12.1
UBE2J1 12.1
nardilysin 11.9
vesicle trafficking protein 11.8
CDKAL1 11.7
MYO16 11.7
VPS26A 11.5
APBB2 11.5
SORCS1 11.4
SLC30A8 11.4
gene/pseudogene 11.3
ECE2 11.3
ECE-2 11.3
glutathione-insulin transhydrogenase 11.3
NADH pyrophosphatase 11.2
kuzbanian 11.2
M-BAR 11.2
Nardilysin 11.1
GABRE 11.1
CAMK1D 11.0
flotillin 1 10.9
phosphatidylinositol binding clathrin assembly protein 10.9
PPARGC1 10.9
A14 10.8
metalloprotease 1 10.8
ARAP1 10.7
N-arginine dibasic convertase 10.7
ADDL 10.7
IGF2BP2 10.7
TFCP2 10.6
WNT8B 10.6
EIF2S1 10.6
SEC22B 10.6
TCF2 10.5
ITM2B 10.4
Golgi reassembly stacking protein 10.4
neutral endopeptidase 10.4
CALHM1 10.3
PLAU 10.3
IFI-56K 10.3
MCJ 10.3
TRIM16 10.2
neurolysin 10.2
ECE-1 10.2
DPYSL2 10.2
USP11 10.2
GAPDS 10.1
NEP2 10.1
metalloendopeptidase 10.1
CDKN3 10.0
zinc metalloendopeptidase 9.9
beta-site APP-cleaving enzyme 1 9.9
TSPAN8 9.8
KSP 9.8
POU2F1 9.8
VRL-1 9.8
ECE1 9.6
IRX3 9.6
tripeptidyl peptidase II 9.6
PLB1 9.6
ADAMTS9 9.6
MTTP 9.5
KLF14 9.5
ALX4 9.5
ABCG4 9.5
NEP 9.5
kallikrein 7 9.5
LRP2 9.4
TCF7L2 9.4
p82 9.4
SREBF2 9.4
PEN2 9.4
CALM1 9.4
Nicastrin 9.3
B17 9.3
PIK3CB 9.3
TNFRSF6 9.2
Cables 9.2
BACE1 9.1
PTIP 9.1
macrophage receptor with collagenous structure 9.1
Grb14 9.0
ECE 9.0
MGC 9.0
carcinoembryonic antigen-related cell adhesion molecule 1 9.0
CHRNB2 9.0
GOT1 9.0
BACE 8.9
LRP1 8.9
A15 8.9
NEP1 8.9
GGA3 8.9
VRK1 8.9
metallopeptidase 8.9
ZIP14 8.9
GRIN1 8.9
SLC2A2 8.8
WFS1 8.8
PS1 8.8
GCK 8.7
HSPG2 8.7
ADAM10 8.6
PMP70 8.6
fat mass and obesity associated 8.6
zinc metallopeptidase 8.6
amyloid beta 8.6
NPFF 8.6
MTNR1B 8.6
APP 8.5
PSEN1 8.5
BRI 8.5
NTE 8.5
nicastrin 8.4
CYBA 8.4
JAZF1 8.4
B28 8.4
insulin-regulated aminopeptidase 8.4
PIK3CD 8.4
B14 8.4
alpha-tocopherol transfer protein 8.4
nuclear respiratory factor 1 8.4
cyclin-dependent kinase inhibitor 2A 8.3
cGMP-PDE 8.3
glutamate carboxypeptidase II 8.3
insulin receptor substrate-2 8.3
Transforming growth factor alpha 8.2
Fe65 8.2
SORL1 8.2
BCL2-associated X protein 8.2
RBP4 8.1
receptor for activated C kinase 1 8.1
zinc-binding protein 8.1
GCKR 8.1
GSTM3 8.1
ADRA2A 8.0
CDK5 8.0
IL-34 8.0
TIM23 8.0
MME 8.0
LGR5 8.0
metalloprotease 7.9
aminopeptidase B 7.9
amyloid precursor protein 7.8
PICALM 7.8
EXT2 7.8
aspartyl protease 7.7
heterogeneous nuclear ribonucleoprotein K 7.7
Neutral endopeptidase 7.7
TA3 7.7
MP1 7.7
putative oncogene 7.7
B22 7.7
ENPP1 7.6
presenilin 1 7.6
GRIN2B 7.6
INSR 7.5
apolipoprotein J 7.5
E2 ubiquitin-conjugating enzyme 7.5
PSEN2 7.5
amylin 7.5
memapsin 2 7.5
amyloid protein 7.5
glycogen synthase kinase 3 beta 7.5
CDC6 7.5
NRF-1 7.5
B13 7.5
Eg5 7.5
rat homolog 7.5
GTPase Ran 7.5
IDA 7.4
RAGE 7.4
NMDAR1 7.4
SOX4 7.3
APOA1 7.3
ENO1 7.3
GIT 7.3
APOE 7.3
IRAK4 7.3
CDKN2B 7.3
phosphotyrosine phosphatase 7.3
insulin-like growth factor 2 7.3
transforming growth factor-alpha 7.3
SOD3 7.3
cathepsin E 7.2
NPR-C 7.2
endoprotease 7.2
insulin receptor 7.2
NPB 7.2
Smad6 7.2
GSL 7.2
zinc transporter 7.2
DM2 7.2
macrophage scavenger receptor 7.1
Cyclin-dependent kinase 5 7.1
transcription factor 7-like 2 7.1
TREM2 7.1
mannose-6-phosphate receptor 7.1
NeuroD 7.1
HEX 7.1
FTO 7.0
ACT1 7.0
CCL18 7.0
IRS2 7.0
B29 7.0
ASH 7.0
AURKA 7.0
complement receptor 1 7.0
cyclin-dependent kinase 5 7.0
fructose 1,6-bisphosphatase 7.0
TDT 7.0
endosomal protein 7.0
Tumor suppressor 6.9
STX 6.9
Tip60 6.9
Drosophila) 6.9
PAX2 6.9
Fractalkine 6.9
beclin 1 6.8
APOB 6.8
Gag polyprotein 6.8
prolyl oligopeptidase 6.8
OPS 6.8
20 copies 6.8
S1P2 6.8
ASI 6.8
apoptosis-related protein 6.7
GCLC 6.7
Aurora-B 6.7
UPS 6.7
Kir6.2 6.7
TfR 6.7
endocytic receptor 6.6
CASP 6.6
preproinsulin 6.6
IRS-2 6.6
CLN2 6.6
FPR2 6.6
sequestosome 1 6.6
formyl peptide receptor 6.6
Metalloproteinase 6.5
ESP 6.5
TBS 6.5
cannabinoid receptor 1 6.5
CMK 6.5
ionized calcium-binding adapter molecule 6.5
MHC class I antigen 6.4
LRP 6.4
MAGE 6.4
IGFBP3 6.4
peptidase 6.4
MTC 6.4
CASP3 6.4
precursor peptide 6.4
RAC1 6.4
Thrombomodulin 6.4
p32 6.4
CTF 6.4
RIN 6.3
LAMP-1 6.3
AKT2 6.3
expressed in testis 6.3
TAU 6.3
cytochrome bc1 6.3
CDC2 6.3
C-type natriuretic peptide 6.3
LDLR 6.3
GTT 6.3
ATP-binding cassette transporter A1 6.3
NL4 6.2
chymotrypsin-like 6.2
differentially expressed protein 6.2
aquaporin 4 6.2
IRS-1 6.2
CAF 6.2
PRNP 6.2
precursor protein 6.2
Apolipoprotein E 6.2
Insulin receptor 6.1
B10 6.1
B15 6.1
mouse homolog 6.1
tPA 6.1
CYP2C 6.1
profilin 6.1
Choline acetyltransferase 6.1
IRF 6.1
proinsulin 6.1
TRPM8 6.0
PPARG 6.0
NT-4/5 6.0
apolipoprotein E 6.0
insulin 6.0
choline kinase 6.0
PACAP 6.0
SNCA 6.0
cathepsin B 6.0
guanine nucleotide binding protein 5.9
RAM 5.9
prodynorphin 5.9
transthyretin 5.9
PCS 5.9
Gag protein 5.9
NMDA receptor subunit 5.9
PON1 5.8
APH 5.8
G10 5.8
dynamin-related protein 1 5.8
cathepsin D 5.8
MEF 5.8
CED 5.8
more...
Disease
Cerebrovascular amyloidosis 12.6
Sporadic cerebral amyloid angiopathy 11.9
Advanced cancer 8.6
Neurodegenerative Disorders 8.3
EXT2 7.8
INS 7.7
APOA1 7.3
DM2 7.2
BED 7.1
biventricular failure 6.9
APOB 6.8
Alzheimer's disease 6.7
denticles 6.5
degenerative disc disease 6.5
cognitive disorder 6.4
TBS 6.3
MTC 6.3
LDLR 6.3
hyperinsulinemia 6.2
Habituation 6.2
corneal dystrophy 6.0
PNET 5.9
memory impairment 5.9
PCS 5.9
cowpox 5.7
tinea capitis 5.6
PAM 5.6
DMS 5.4
Testis 5.4
Testis 5.4
glucose intolerance 5.3
type 2 diabetes 5.3
diabetic foot ulcers 5.3
varicella 5.3
Johne's disease 5.2
cholecystolithiasis 5.1
insulinoma 5.1
cognitive impairment 5.0
skin infection 5.0
senile dementia 4.8
Dementia with Lewy bodies 4.7
coccidiosis 4.7
spinal stenosis 4.6
plaque 4.6
Fibrillation 4.6
Dependence 4.6
Albert 4.5
ICS 4.5
gestational trophoblastic disease 4.4
EDA 4.4
dementia 4.4
lipodystrophy 4.3
HLA-B27 4.2
iron deficiency 4.2
biliary obstruction 4.1
STS 4.1
social stress 4.1
radiculopathy 4.1
acne vulgaris 4.1
brain dysfunction 4.0
neuroblastoma 4.0
vascular disease 3.9
ACP 3.9
amyloidosis 3.9
AAA 3.8
diabetes 3.8
Recruitment 3.8
hyperhomocysteinemia 3.7
acne 3.7
APC 3.7
IBM 3.6
Down syndrome 3.6
macular degeneration 3.6
Lyme disease 3.6
cholecystitis 3.6
retinoblastoma 3.5
immunopathology 3.4
myeloid leukemia 3.4
hyperglycemia 3.4
diabetic retinopathy 3.4
hypoglycemia 3.3
immaturity 3.3
Prostate Cancer 3.3
thymoma 3.2
Disorder 3.2
Yersinia 3.1
neoplastic transformation 3.1
metabolic disorder 3.1
SDS 3.1
herpes zoster 3.1
retinitis pigmentosa 3.1
gallstones 3.0
amnesia 3.0
eczema 2.9
cerebral ischemia 2.9
muscular dystrophy 2.9
metabolic syndrome 2.8
Evans 2.8
skin disease 2.8
urticaria 2.7
PDB 2.7
dyslipidemia 2.6
hypercholesterolemia 2.5
wasting 2.4
Cryptococcus neoformans 2.4
herpes 2.3
abdominal aortic aneurysm 2.3
Still 2.3
hepatocellular carcinoma 2.3
Blocking 2.2
Steroids 2.2
obesity 2.2
gastritis 2.1
type 1 diabetes 2.1
Parkinson's disease 2.0
myopathy 1.9
brain tumor 1.8
anemia 1.7
Huntington's disease 1.7
Autism 1.7
fatty liver 1.6
myelopathy 1.6
herpes simplex 1.6
cirrhosis 1.6
pheochromocytoma 1.6
ash 1.5
mental retardation 1.4
mental retardation 1.4
virus infection 1.4
migraine 1.3
ischemia 1.2
hypertension 1.2
amyotrophic lateral sclerosis 1.2
tumorigenesis 1.2
pertussis 1.1
primary tumor 1.1
TEM 1.1
meningitis 1.0
TEM 1.0
chronic renal failure 0.9
melanoma 0.9
cornea 0.9
dehydration 0.9
stroke 0.8
tuberculosis 0.8
sarcoma 0.7
Mycobacterium 0.7
addiction 0.6
ovarian cancer 0.6
MCF 0.6
malnutrition 0.6
cold 0.5
liver disease 0.5
fits 0.5
autism 0.4
uterus 0.4
hepatitis C 0.4
HIV 0.3
acute myeloid leukemia 0.3
multiple myeloma 0.3
West 0.2
GSH 0.2
breast cancer 0.1
tumor progression 0.1
malaria -0.1
tumor -0.4
tumor growth -0.4
prostate cancer -0.5
cardiovascular disease -0.6
adenocarcinoma -0.7
immunodeficiency -0.7
lung cancer -0.7
heart failure -0.7
lymphoma -0.7
carcinoma -0.8
infectious diseases -0.9
cancer -1.3
AIDS -1.5
depression -2.0
Symptom
arm pain 6.4
Decreased activity 6.3
memory loss 5.6
functional recovery 1.7
anorexia 1.6
anesthesia -0.4
diarrhea -0.4
Drug
Urso 10.8
Poudre 8.5
Idebenone 8.5
Lead acetate 8.1
Calcium chloride 7.6
Ammonium chloride 7.5
Perindopril 7.0
DEL 7.0
Liraglutide 6.6
Aprotinin 6.6
MTC 6.4
Donepezil 6.3
Activin 6.3
Glucagon 5.5
ADM 5.4
uPA 5.4
Apomorphine 5.1
ZnCl2 5.0
ZnCl2 5.0
Meth 5.0
CTA 4.9
Gleevec 4.9
Ginseng 4.7
Parkin 4.5
Parkin 4.5
Fructose 4.5
DMI 4.3
Glycerol 4.2
Imatinib 4.1
Alanine 4.0
ALA 3.9
Gel 3.9
Vitamin E 3.7
Spectrum 3.4
Glutathione 3.0
FAD 3.0
CaCl2 2.7
CSF 2.5
EE2 2.5
Spectrum 2.5
DNase I 2.4
ABC 2.3
Asn 1.9
MAP 1.5
Nephron 1.3
ROS 1.2
ascorbate 0.9
IL-2 0.6
lysine -0.4
Dermatol -1.0
Cardiovasc -2.2
Enzyme
EC 3.4.24.54 15.4
insulin-degrading enzyme 15.4
IDS3 12.4
glutathione-insulin transhydrogenase 12.2
IDS2 12.2
nardilysin 12.2
NADH pyrophosphatase 11.5
endothelin-converting enzyme 10.5
PTR 10.3
polysaccharide deacetylase 9.9
neurolysin 9.8
thimet oligopeptidase 9.3
CD10 9.0
beta-secretase 8.6
tripeptidyl peptidase 8.3
transhydrogenase 7.9
KLK7 7.9
aminopeptidase B 7.6
inositol 3-kinase 7.5
thermolysin 6.8
endoproteinase Glu-C 6.7
choline kinase 6.6
MPP 6.5
lysyl endopeptidase 6.4
PTPase 6.4
SMP 6.0
cathepsin D 6.0
plasmin 6.0
cathepsin B 6.0
TPP 5.9
fructose 1,6-bisphosphatase 5.8
prolyl endopeptidase 5.8
PAM 5.5
acyl-CoA oxidase 5.5
cathepsin L 5.5
proteasome 5.4
furin 5.3
neuropathy target esterase 5.3
TPP 5.1
GSK 5.0
TOR 4.9
PNGase F 4.8
apyrase 4.8
phosphoglucose isomerase 4.7
MMP-3 4.7
prostate-specific membrane antigen 4.6
HIV-1 protease 4.4
matrix metalloproteinase 9 4.3
ACE 4.0
sialidase 4.0
glucose oxidase 4.0
glucokinase 3.9
acetyl-CoA carboxylase 3.9
AMPK 3.8
aldolase 3.6
urokinase-type plasminogen activator 3.6
chymotrypsin 3.6
CaMKII 3.4
proteinase K 3.4
APC 3.4
AMPK 3.4
cholinesterase 3.4
MMP 3.3
AMP-activated protein kinase 3.3
subtilisin 3.3
citrate synthase 3.3
malate dehydrogenase 3.2
acetylcholinesterase 3.2
protein kinase 3.1
CPR 3.0
alpha-amylase 3.0
trypsin 3.0
hexokinase 3.0
lysozyme 3.0
RNase 3.0
tissue plasminogen activator 2.9
dihydrofolate reductase 2.9
phosphoinositide 3-kinase 2.9
diaphorase 2.9
RNase 2.9
choline acetyltransferase 2.8
ERK 2.8
ribonuclease 2.7
ribonuclease 2.7
caspase-8 2.7
prostate-specific antigen 2.6
MAP 2.5
caspase-9 2.5
beta-glucuronidase 2.5
mitogen-activated protein kinase 2.4
cdc2 2.4
complex I 2.3
transcriptase 2.2
NADPH oxidase 2.1
glutathione peroxidase 2.0
phosphatidylinositol 3-kinase 2.0
NADPH oxidase 1.9
protein kinase C 1.8
P-glycoprotein 1.7
neuraminidase 1.6
lactate dehydrogenase 1.6
ACS 1.5
ATPase 1.4
caspase-3 1.3
renin 1.3
catalase 1.2
phosphodiesterase 1.2
glutathione S-transferase 0.9
superoxide dismutase 0.6
thrombin 0.4
RNA polymerase 0.3
focal adhesion kinase -0.0
alkaline phosphatase -0.1
peroxidase -0.6
Compound
Pratensein 13.1
X 48 11.6
AFU 9.9
A-14 9.9
Bacitracin 9.5
Triphosphate 9.5
threonate 9.4
B17 9.3
2-butenoic acid 9.3
1,6-hexanedithiol 9.2
1,6-hexanedithiol 9.2
Geniposide 9.1
2-butenoic acid 9.1
Thiorphan 8.5
Nelfinavir 7.9
Tauroursodeoxycholic acid 7.7
Geigy 7.5
DBI 7.5
Digitonin 7.4
IDA 7.4
Formin 7.3
Leupeptin 7.3
Perindopril 7.2
TME 7.1
Hesperidin 7.1
MME 7.0
Cotinine 6.9
Leupeptin 6.9
Pyrroloquinoline quinone 6.8
Insulin 6.8
His-Leu 6.6
TCA 6.5
TBS 6.5
Triptolide 6.4
MTC 6.4
[1,10]phenanthroline 6.4
APH 6.3
octanoic acid 6.2
CMK 6.2
Memantine 6.1
Thioflavin T 6.0
Wellcome 6.0
Plasmin 5.8
IPA 5.7
IPA 5.7
IPA 5.7
IPA 5.7
Polypeptide 5.7
Chloroquine 5.5
Chloroquine 5.5
E-64 5.5
Glucagon 5.5
NEM 5.5
MEP 5.4
RU-486 5.3
MEP 5.3
MK801 5.1
STZ 5.1
PAM 5.1
Congo red 5.1
TPP 5.0
Adenine 4.9
tellurium 4.9
Losartan 4.9
DMS 4.8
MMA 4.7
2-nonenal 4.7
ubiquinol 4.7
HVA 4.7
MPP 4.6
TPP 4.6
MPP 4.6
PAM 4.5
PAM 4.5
MSM 4.5
Corticosterone 4.4
Fructose 4.4
Propranolol 4.4
Propranolol 4.4
FFA 4.3
Bradykinin 4.3
DMI 4.3
DMI 4.3
TPP 4.2
Lidocaine 4.2
Leucine 4.2
HEPES 4.1
EDTA 4.1
EDTA 4.1
NTA 4.1
Hematoxylin 4.1
zinc 4.0
Ubiquitin 4.0
Capsaicin 4.0
Alanine 4.0
Diabetol 4.0
Phe 3.9
valine 3.9
AAA 3.9
PAC 3.9
leucine 3.8
COS 3.8
aspartic acid 3.8
SCC 3.7
trifluoroacetic acid 3.7
trifluoroacetic acid 3.7
trifluoroacetic acid 3.7
trifluoroacetic acid 3.7
palmitic acid 3.7
Cysteine 3.7
Metformin 3.7
Valproic acid 3.7
trifluoroacetic acid 3.7
Metformin 3.7
aspartic acid 3.6
aspartic acid 3.6
Diabetol 3.6
tyrosine 3.6
PDB 3.5
CAP 3.5
DEAE 3.5
aspartic acid 3.5
Asp 3.5
serine 3.4
Vitamin E 3.4
glucose 3.3
Salt 3.3
manganese 3.3
DHA 3.3
DBP 3.3
ABA 3.3
guanidine 3.2
aluminum 3.2
DHA 3.2
MgCl2 3.2
CCl4 3.1
SDS 3.1
Lead 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
formic acid 3.1
Estrogen 3.1
ABA 3.0
Norepinephrine 3.0
TNF 3.0
FAD 2.9
Neuronal 2.9
pyrrolidine 2.9
Testosterone 2.9
ATP 2.8
asparagine 2.8
Testosterone 2.8
chromium 2.8
Estradiol 2.8
adenylate 2.8
alanine 2.7
CaCl2 2.7
His 2.7
Vitamin D 2.7
DHA 2.7
Isoproterenol 2.7
Adenosine 2.7
vanadium 2.6
Ile 2.6
palmitic acid 2.6
cobalt 2.6
ammonium 2.6
acridine 2.6
dUTP 2.5
PMA 2.4
proline 2.4
DMSO 2.4
methionine 2.4
adenosylmethionine 2.4
acrylamide 2.3
threonine 2.3
Angiotensin II 2.3
glutamine 2.3
BCG 2.3
Collagen 2.2
Sodium 2.2
MAP 2.2
Estrogen 2.2
isopropanol 2.2
Cholesterol 2.1
isoleucine 2.1
sulfate 2.1
lysine 2.1
Tris 2.1
CAM 2.1
phosphoric acid 2.1
anthracene 2.1
isoleucine 2.1
AMP 2.0
acetone 2.0
arginine 2.0
sodium chloride 1.9
homocysteine 1.9
NH2 1.9
tin 1.9
PMA 1.8
hyaluronic acid 1.8
cysteine 1.8
ethyl acetate 1.7
mercury 1.7
Cereb 1.6
ADP 1.6
glutamate 1.6
ACS 1.5
ACS 1.5
NMDA 1.4
chlorine 1.4
MTT 1.4
nicotinamide 1.4
nitric oxide 1.4
Gly 1.3
cadmium 1.3
acetic acid 1.3
toluene 1.2
copper 1.2
galactose 1.2
ADP 1.2
ADP 1.2
acetate 1.1
glycerol 1.1
TOF 1.1
GSH 1.1
GSH 1.1
water 1.0
cGMP 1.0
phosphate 1.0
iron 0.9
sodium 0.9
TEM 0.9
MDA 0.8
retinoic acid 0.8
vitamin D 0.6
Mg2+ 0.6
salt 0.6
cAMP 0.6
silver 0.5
nickel 0.5
5-HT 0.4
urea 0.4
noradrenaline 0.4
tryptophan 0.3
tryptophan 0.3
tryptophan 0.3
calcium 0.2
Dec 0.2
tryptophan 0.1
DNA -0.0
phosphorus -0.1
potassium -0.1
iodine -0.2
oxygen -0.3
PEG -0.4
hydrogen -0.7
Clin -0.8
nitrogen -0.9
ethanol -1.7
Cardiol -2.4