Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.56 (insulin-degrading enzyme)
 737 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin-degrading enzyme 632
insulin 309
neutral endopeptidase 105
amyloid precursor protein 96
insulinase 58
amyloid beta 47
Mol 44
APP 40
Sep 37
insulysin 35
insulin receptor 33
BACE1 30
glucagon 30
PS1 28
metalloprotease 27
proteasome 25
ATP 22
A14 21
HHEX 20
peptidase 18
MGC 16
metalloendopeptidase 15
amylin 12
glycoprotein 12
ubiquitin 11
TNF 11
apolipoprotein E 11
SDS 10
APOE 10
NEP 10
metallopeptidase 10
polypeptide 10
CDKAL1 10
glial fibrillary acidic protein 9
IRS-1 8
precursor protein 8
ADAM10 8
BACE 8
beta-endorphin 8
TCF7L2 8
endoplasmic reticulum 8
B17 8
SLC30A8 8
tumor necrosis factor 8
membrane-bound 7
PreP 7
brain-derived neurotrophic factor 7
B10 7
proinsulin 7
glutathione-insulin transhydrogenase 7
insulin-like growth factor 7
peroxisome proliferator-activated receptor gamma 6
KSP 6
cathepsin D 6
metalloproteinase 6
tyrosine kinase 6
amyloid protein 6
cathepsin B 6
RAGE 6
p38 6
synuclein 6
A15 6
Met 5
ACE 5
PI3K 5
transforming growth factor-alpha 5
protease inhibitor 5
TCA 5
transthyretin 5
trypsin inhibitor 5
peroxisome proliferator-activated receptor 5
extracellular signal-regulated kinase 5
cysteine protease 5
PLAU 5
ECE-1 5
fused 5
presenilin 1 5
epidermal growth factor 5
ACS 5
matrix metalloproteinase 5
cytokine 5
IGF2BP2 4
growth hormone 4
ATPase 4
AMP 4
dynorphin 4
AKT 4
synaptophysin 4
IL-6 4
lysozyme 4
Kir6.2 4
cytochrome c 4
natriuretic peptide 4
serum albumin 4
PSEN1 4
histone 4
NRDC 4
B14 4
FTO 4
plasminogen 4
ECE 4
aspartyl protease 4
WFS1 4
inducible nitric oxide synthase 4
nardilysin 4
atrial natriuretic peptide 4
LRP1 4
CSF 4
GSK 4
tau protein 4
B13 4
hemoglobin 4
CA1 3
CDK5 3
bradykinin 3
PSD-95 3
fur 3
caspase-3 3
catalase 3
IL-4 3
NMDA receptor 3
MMP-2 3
low-density lipoprotein receptor 3
albumin 3
endoprotease 3
MHC class I 3
interleukin-6 3
alphaT-catenin 3
CD36 3
APC 3
Apolipoprotein E 3
protein kinase B 3
MMP-9 3
MMP9 3
GCK 3
IGF-II 3
somatostatin 3
B12 3
serine protease 3
insulin-like growth factor I 3
IL-10 3
chymotrypsin-like 3
DM2 3
ECE-2 3
IDA 3
collagen 3
acetylcholinesterase 3
cyclooxygenase-2 3
nicastrin 3
threonine 3
CDKN2A 3
GIT 3
urokinase-type plasminogen activator 3
retinoic acid receptor 2
alpha-synuclein 2
unknown function 2
STZ 2
RIN 2
glutathione peroxidase 2
profilin 2
AMPK 2
HSP70 2
atrial natriuretic factor 2
PAM 2
ERK1 2
IRS-2 2
calcitonin 2
LRP 2
LDLR 2
histone deacetylase 2
superoxide dismutase 2
SOD1 2
neurolysin 2
tumor suppressor protein 2
NMDAR1 2
LPS 2
PTEN 2
C-type natriuretic peptide 2
insulin-like growth factor 2 2
protein tyrosine phosphatase 2
cannabinoid receptor 2
Beclin-1 2
HDAC 2
ERK 2
Nicastrin 2
mucin 2
axonal 2
CHOP 2
ADP 2
interleukin-10 2
ECE1 2
LC3 2
CD68 2
CDKN2B 2
BRI 2
CaMKII 2
renin 2
epidermal growth factor receptor 2
glucose transporter 2
lactate dehydrogenase 2
NeuroD 2
nuclear respiratory factor 1 2
SOD2 2
kuzbanian 2
cathepsin L 2
alpha-tocopherol transfer protein 2
transferrin receptor 2
PDB 2
brain-derived 2
ferritin 2
microsomal 2
MMP-3 2
IGF-I 2
MLR 2
LGR5 2
cage 2
aminopeptidase 2
AChE 2
apoE 2
Env 2
TCF2 2
chymotrypsin 2
cryptic 2
FRAP 2
prolactin 2
LAMP-1 2
phosphotyrosine phosphatase 2
thymus 2
Gag 2
chemokine 2
zinc transporter 2
COX-2 2
glycogen synthase kinase 3 beta 2
SORCS1 2
LRP2 2
MRI 2
RNase 2
GLP-1 receptor 2
Eg5 2
MAGE 2
ADAMTS9 2
tPA 2
STAT3 2
cyclin-dependent kinase 5 2
Bcl-2 2
homeobox 2
CALHM1 2
OPS 1
INK4a 1
HAS 1
RANTES 1
protein disulfide isomerase 1
esterase 1
AMP-activated protein kinase 1
cyclin-dependent kinase inhibitor 2A 1
TFAM 1
OX40 1
hormone receptor 1
IFI-56K 1
SORL1 1
erythroid 1
chemokine receptor 1
PDX-1 1
malate dehydrogenase 1
UPS 1
cystatin C 1
ASI 1
MPP 1
APBB2 1
vesicle trafficking protein 1
cyclooxygenase 1
sequestosome 1 1
TOF 1
CD40 1
San 1
c-fos 1
deubiquitinating enzyme 1
nitric oxide synthase 1
putative tumor suppressor 1
UBE2J1 1
GABRE 1
TFCP2 1
TBS 1
LDH 1
beclin 1 1
PLB1 1
JAZF1 1
NOS2 1
p32 1
neurotrophic factor 1
FGF2 1
microtubule associated protein 1
API 1
NPR-C 1
AKT1 1
tripeptidyl peptidase II 1
MMP-13 1
mTOR 1
CAF 1
PIK3CB 1
peroxisome proliferator activated receptor 1
transcription factor 7-like 2 1
ADRA2A 1
alpha-amylase 1
TPP 1
insulin receptor substrate-2 1
ALX4 1
STX 1
cyclin-dependent kinase 1
IRS2 1
Bak 1
PGC 1
N-glycanase 1
Grb14 1
ATP-binding cassette 1
ADDL 1
NPFF 1
Bcl-X 1
ESR1 1
cannabinoid receptor 1 1
more...
Disease
Alzheimer's disease 273
diabetes 89
type 2 diabetes 53
plaque 31
cognitive impairment 27
dementia 27
hyperinsulinemia 18
obesity 13
tumor 12
glucose intolerance 11
cancer 10
memory impairment 10
neuroblastoma 10
SDS 10
hypertension 9
hepatocellular carcinoma 8
varicella 8
hyperglycemia 7
INS 7
stroke 6
Parkinson's disease 6
vascular disease 6
HIV 5
hypoglycemia 5
ischemia 5
breast cancer 4
anemia 4
metabolic syndrome 4
Down syndrome 4
amyloidosis 4
iron deficiency 3
DM2 3
insulinoma 3
virus infection 3
tuberculosis 3
cerebral ischemia 3
cold 3
cirrhosis 3
tumorigenesis 3
APC 3
melanoma 3
retinoblastoma 3
herpes simplex 2
carcinoma 2
type 1 diabetes 2
Mycobacterium 2
Yersinia 2
skin disease 2
hypercholesterolemia 2
West 2
degenerative disc disease 2
gallstones 2
PAM 2
macular degeneration 2
Evans 2
diabetic retinopathy 2
acne 2
dyslipidemia 2
Lyme disease 2
LDLR 2
Johne's disease 1
herpes 1
tinea capitis 1
EXT2 1
hepatitis C 1
primary tumor 1
Blocking 1
wasting 1
TBS 1
PNET 1
EDA 1
STS 1
adenocarcinoma 1
IBM 1
senile dementia 1
liver disease 1
myeloid leukemia 1
PDB 1
Neurodegenerative Disorders 1
addiction 1
heart failure 1
herpes zoster 1
chronic renal failure 1
social stress 1
spinal stenosis 1
immaturity 1
Prostate Cancer 1
infectious diseases 1
depression 1
sarcoma 1
autism 1
immunodeficiency 1
MCF 1
multiple myeloma 1
prostate cancer 1
ACP 1
myopathy 1
gastritis 1
biliary obstruction 1
abdominal aortic aneurysm 1
ICS 1
lung cancer 1
muscular dystrophy 1
tumor progression 1
meningitis 1
TEM 1
tumor growth 1
Cryptococcus neoformans 1
acne vulgaris 1
DMS 1
malnutrition 1
Disorder 1
AIDS 1
Dependence 1
APOA1 1
ovarian cancer 1
pheochromocytoma 1
urticaria 1
uterus 1
migraine 1
mental retardation 1
PCS 1
coccidiosis 1
malaria 1
cholecystolithiasis 1
mental retardation 1
dehydration 1
corneal dystrophy 1
cognitive disorder 1
Advanced cancer 1
GSH 1
amnesia 1
thymoma 1
skin infection 1
fatty liver 1
Autism 1
biventricular failure 1
Testis 1
neoplastic transformation 1
acute myeloid leukemia 1
Huntington's disease 1
Testis 1
brain dysfunction 1
ash 1
pertussis 1
eczema 1
metabolic disorder 1
hyperhomocysteinemia 1
myelopathy 1
HLA-B27 1
Albert 1
lipodystrophy 1
Cerebrovascular amyloidosis 1
Habituation 1
AAA 1
fits 1
Fibrillation 1
immunopathology 1
cowpox 1
brain tumor 1
APOB 1
Dementia with Lewy bodies 1
amyotrophic lateral sclerosis 1
cholecystitis 1
radiculopathy 1
Still 1
MTC 1
BED 1
denticles 1
retinitis pigmentosa 1
cardiovascular disease 1
Sporadic cerebral amyloid angiopathy 1
Recruitment 1
gestational trophoblastic disease 1
lymphoma 1
diabetic foot ulcers 1
TEM 1
cornea 1
Steroids 1
Symptom
memory loss 4
anesthesia 2
functional recovery 1
anorexia 1
arm pain 1
Decreased activity 1
diarrhea 1
Drug
Gel 5
CSF 4
Glucagon 4
ADM 3
Activin 3
Dermatol 3
Aprotinin 2
uPA 2
DMI 1
Apomorphine 1
Perindopril 1
Idebenone 1
Ginseng 1
Fructose 1
Donepezil 1
ALA 1
Poudre 1
CTA 1
Imatinib 1
CaCl2 1
Glutathione 1
Glycerol 1
Meth 1
DNase I 1
MTC 1
lysine 1
Asn 1
ZnCl2 1
Alanine 1
Nephron 1
Ammonium chloride 1
Liraglutide 1
ZnCl2 1
ABC 1
MAP 1
Cardiovasc 1
Lead acetate 1
Gleevec 1
ascorbate 1
Calcium chloride 1
EE2 1
FAD 1
ROS 1
Spectrum 1
Parkin 1
Parkin 1
Vitamin E 1
Urso 1
Spectrum 1
IL-2 1
DEL 1
Enzyme
insulin-degrading enzyme 737
CD10 118
proteasome 28
endothelin-converting enzyme 21
protein kinase 16
ERK 15
plasmin 13
PTR 13
mitogen-activated protein kinase 12
trypsin 8
glutathione-insulin transhydrogenase 8
beta-secretase 8
nardilysin 7
ACE 7
cathepsin D 6
cathepsin B 6
acetylcholinesterase 6
thermolysin 5
ACS 5
GSK 5
MPP 4
APC 4
protein kinase C 4
lysozyme 4
transhydrogenase 4
ATPase 4
cholinesterase 3
thimet oligopeptidase 3
urokinase-type plasminogen activator 3
furin 3
catalase 3
AMPK 3
RNase 3
RNase 3
AMP-activated protein kinase 3
chymotrypsin 3
tissue plasminogen activator 2
glucose oxidase 2
superoxide dismutase 2
neurolysin 2
MMP-3 2
caspase-3 2
lactate dehydrogenase 2
PAM 2
glutathione peroxidase 2
renin 2
cathepsin L 2
AMPK 2
TPP 2
PTPase 2
subtilisin 1
TOR 1
proteinase K 1
NADH pyrophosphatase 1
caspase-8 1
focal adhesion kinase 1
IDS3 1
beta-glucuronidase 1
phosphodiesterase 1
neuraminidase 1
aldolase 1
prostate-specific membrane antigen 1
IDS2 1
hexokinase 1
MMP 1
diaphorase 1
neuropathy target esterase 1
prostate-specific antigen 1
caspase-9 1
polysaccharide deacetylase 1
choline acetyltransferase 1
CaMKII 1
phosphatidylinositol 3-kinase 1
malate dehydrogenase 1
endoproteinase Glu-C 1
PNGase F 1
peroxidase 1
phosphoinositide 3-kinase 1
ribonuclease 1
cdc2 1
EC 3.4.24.54 1
sialidase 1
KLK7 1
matrix metalloproteinase 9 1
NADPH oxidase 1
NADPH oxidase 1
MAP 1
prolyl endopeptidase 1
alpha-amylase 1
complex I 1
apyrase 1
dihydrofolate reductase 1
phosphoglucose isomerase 1
glucokinase 1
P-glycoprotein 1
transcriptase 1
glutathione S-transferase 1
acyl-CoA oxidase 1
choline kinase 1
aminopeptidase B 1
HIV-1 protease 1
ribonuclease 1
alkaline phosphatase 1
acetyl-CoA carboxylase 1
RNA polymerase 1
inositol 3-kinase 1
citrate synthase 1
SMP 1
TPP 1
tripeptidyl peptidase 1
CPR 1
thrombin 1
fructose 1,6-bisphosphatase 1
lysyl endopeptidase 1
Compound
Insulin 71
glucose 71
Dec 55
zinc 34
water 33
tyrosine 27
ATP 22
Clin 21
leucine 20
DNA 19
TCA 19
Phe 18
serine 16
His 12
sodium 12
EDTA 11
SDS 11
alanine 11
EDTA 11
TNF 11
sulfate 11
arginine 9
ammonium 9
Asp 9
calcium 9
B17 8
phosphate 8
manganese 8
lysine 8
oxygen 7
methionine 7
aluminum 6
iron 6
nitric oxide 6
acetate 6
cysteine 6
Bacitracin 5
copper 5
threonine 5
ACS 5
valine 5
glutamate 5
ACS 5
NH2 4
DEAE 4
cobalt 4
salt 4
AMP 4
aspartic acid 4
proline 4
Glucagon 4
COS 4
galactose 4
Diabetol 3
IDA 3
chromium 3
Diabetol 3
ADP 3
Ile 3
palmitic acid 3
Wellcome 3
aspartic acid 3
hydrogen 3
glutamine 3
Congo red 3
STZ 3
aspartic acid 3
aspartic acid 3
MTT 2
ADP 2
acetic acid 2
formic acid 2
Lead 2
formic acid 2
ADP 2
Chloroquine 2
PAM 2
Geniposide 2
mercury 2
urea 2
guanidine 2
formic acid 2
formic acid 2
Adenine 2
glycerol 2
formic acid 2
Neuronal 2
Propranolol 2
GSH 2
Chloroquine 2
nitrogen 2
Estrogen 2
Gly 2
Propranolol 2
PAM 2
asparagine 2
formic acid 2
formic acid 2
potassium 2
formic acid 2
PAM 2
GSH 2
silver 2
Triphosphate 2
formic acid 2
acetone 2
DMSO 2
octanoic acid 2
cAMP 2
cadmium 2
Salt 2
formic acid 2
acrylamide 2
IPA 1
Metformin 1
CAP 1
MAP 1
vitamin D 1
anthracene 1
APH 1
sodium chloride 1
TPP 1
TBS 1
phosphorus 1
Lidocaine 1
PAC 1
MPP 1
Estrogen 1
DBI 1
Capsaicin 1
IPA 1
trifluoroacetic acid 1
TPP 1
CCl4 1
Pyrroloquinoline quinone 1
Angiotensin II 1
ethanol 1
2-butenoic acid 1
Leupeptin 1
Testosterone 1
vanadium 1
MDA 1
Metformin 1
Leucine 1
[1,10]phenanthroline 1
Perindopril 1
Mg2+ 1
adenylate 1
FAD 1
Thiorphan 1
IPA 1
dUTP 1
Cereb 1
Adenosine 1
tryptophan 1
Losartan 1
MSM 1
DHA 1
Tauroursodeoxycholic acid 1
tryptophan 1
TEM 1
MMA 1
Thioflavin T 1
Memantine 1
Nelfinavir 1
HVA 1
Formin 1
tryptophan 1
CAM 1
acridine 1
Cardiol 1
Bradykinin 1
E-64 1
PMA 1
ethyl acetate 1
A-14 1
trifluoroacetic acid 1
DBP 1
tellurium 1
CaCl2 1
ubiquinol 1
PDB 1
noradrenaline 1
trifluoroacetic acid 1
FFA 1
Vitamin D 1
Valproic acid 1
IPA 1
Cysteine 1
Vitamin E 1
HEPES 1
Cholesterol 1
His-Leu 1
Corticosterone 1
TPP 1
TOF 1
MK801 1
trifluoroacetic acid 1
SCC 1
Plasmin 1
Cotinine 1
Alanine 1
Digitonin 1
MEP 1
BCG 1
Hematoxylin 1
DHA 1
CMK 1
tryptophan 1
nickel 1
Estradiol 1
AFU 1
homocysteine 1
Isoproterenol 1
MTC 1
Polypeptide 1
Fructose 1
MME 1
trifluoroacetic acid 1
PEG 1
RU-486 1
1,6-hexanedithiol 1
ABA 1
NTA 1
Pratensein 1
2-nonenal 1
Collagen 1
AAA 1
NMDA 1
retinoic acid 1
phosphoric acid 1
hyaluronic acid 1
MEP 1
1,6-hexanedithiol 1
PMA 1
chlorine 1
cGMP 1
X 48 1
isoleucine 1
Sodium 1
isopropanol 1
Norepinephrine 1
Hesperidin 1
nicotinamide 1
pyrrolidine 1
DMS 1
threonate 1
tin 1
Ubiquitin 1
NEM 1
isoleucine 1
Triptolide 1
ABA 1
DHA 1
Testosterone 1
TME 1
adenosylmethionine 1
DMI 1
palmitic acid 1
DMI 1
iodine 1
5-HT 1
MgCl2 1
toluene 1
Geigy 1
MPP 1
Leupeptin 1
Tris 1
2-butenoic acid 1