Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.56 (insulin-degrading enzyme)
 737 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin-degrading enzyme 632
insulin 309
neutral endopeptidase 105
amyloid precursor protein 96
insulinase 58
amyloid beta 47
Mol 44
APP 40
Sep 37
insulysin 35
insulin receptor 33
glucagon 30
BACE1 30
PS1 28
metalloprotease 27
proteasome 25
ATP 22
A14 21
HHEX 20
peptidase 18
MGC 16
metalloendopeptidase 15
glycoprotein 12
amylin 12
apolipoprotein E 11
TNF 11
ubiquitin 11
NEP 10
metallopeptidase 10
APOE 10
SDS 10
CDKAL1 10
polypeptide 10
glial fibrillary acidic protein 9
endoplasmic reticulum 8
TCF7L2 8
SLC30A8 8
BACE 8
tumor necrosis factor 8
precursor protein 8
B17 8
beta-endorphin 8
IRS-1 8
ADAM10 8
membrane-bound 7
glutathione-insulin transhydrogenase 7
B10 7
insulin-like growth factor 7
proinsulin 7
PreP 7
brain-derived neurotrophic factor 7
amyloid protein 6
synuclein 6
peroxisome proliferator-activated receptor gamma 6
metalloproteinase 6
cathepsin D 6
tyrosine kinase 6
KSP 6
p38 6
A15 6
RAGE 6
cathepsin B 6
transthyretin 5
ECE-1 5
matrix metalloproteinase 5
ACS 5
peroxisome proliferator-activated receptor 5
presenilin 1 5
transforming growth factor-alpha 5
protease inhibitor 5
cytokine 5
TCA 5
cysteine protease 5
ACE 5
PI3K 5
extracellular signal-regulated kinase 5
PLAU 5
fused 5
epidermal growth factor 5
trypsin inhibitor 5
Met 5
serum albumin 4
ECE 4
aspartyl protease 4
WFS1 4
plasminogen 4
lysozyme 4
ATPase 4
CSF 4
LRP1 4
growth hormone 4
atrial natriuretic peptide 4
GSK 4
natriuretic peptide 4
IL-6 4
AKT 4
tau protein 4
B13 4
histone 4
AMP 4
cytochrome c 4
dynorphin 4
B14 4
FTO 4
nardilysin 4
IGF2BP2 4
inducible nitric oxide synthase 4
NRDC 4
PSEN1 4
synaptophysin 4
Kir6.2 4
hemoglobin 4
serine protease 3
NMDA receptor 3
insulin-like growth factor I 3
IL-10 3
chymotrypsin-like 3
nicastrin 3
fur 3
ECE-2 3
low-density lipoprotein receptor 3
catalase 3
Apolipoprotein E 3
albumin 3
IDA 3
acetylcholinesterase 3
endoprotease 3
MMP-2 3
alphaT-catenin 3
MHC class I 3
CDK5 3
interleukin-6 3
GIT 3
B12 3
IL-4 3
protein kinase B 3
CD36 3
caspase-3 3
APC 3
threonine 3
MMP9 3
bradykinin 3
PSD-95 3
CA1 3
urokinase-type plasminogen activator 3
CDKN2A 3
DM2 3
collagen 3
cyclooxygenase-2 3
IGF-II 3
GCK 3
somatostatin 3
MMP-9 3
ferritin 2
LGR5 2
alpha-synuclein 2
IGF-I 2
MMP-3 2
cage 2
MLR 2
more...
Disease
Alzheimer's disease 273
diabetes 89
type 2 diabetes 53
plaque 31
cognitive impairment 27
dementia 27
hyperinsulinemia 18
obesity 13
tumor 12
glucose intolerance 11
cancer 10
neuroblastoma 10
memory impairment 10
SDS 10
hypertension 9
varicella 8
hepatocellular carcinoma 8
hyperglycemia 7
INS 7
stroke 6
vascular disease 6
Parkinson's disease 6
HIV 5
ischemia 5
hypoglycemia 5
breast cancer 4
metabolic syndrome 4
anemia 4
amyloidosis 4
Down syndrome 4
iron deficiency 3
insulinoma 3
melanoma 3
tuberculosis 3
DM2 3
virus infection 3
cerebral ischemia 3
cirrhosis 3
cold 3
APC 3
tumorigenesis 3
retinoblastoma 3
herpes simplex 2
carcinoma 2
Mycobacterium 2
Yersinia 2
skin disease 2
gallstones 2
type 1 diabetes 2
hypercholesterolemia 2
degenerative disc disease 2
macular degeneration 2
PAM 2
Evans 2
diabetic retinopathy 2
acne 2
LDLR 2
West 2
Lyme disease 2
dyslipidemia 2
Johne's disease 1
herpes 1
tinea capitis 1
EXT2 1
hepatitis C 1
primary tumor 1
Blocking 1
wasting 1
TBS 1
PNET 1
EDA 1
STS 1
adenocarcinoma 1
IBM 1
senile dementia 1
liver disease 1
myeloid leukemia 1
PDB 1
Neurodegenerative Disorders 1
addiction 1
heart failure 1
herpes zoster 1
chronic renal failure 1
social stress 1
spinal stenosis 1
immaturity 1
infectious diseases 1
Prostate Cancer 1
cowpox 1
autism 1
immunodeficiency 1
MCF 1
APOB 1
radiculopathy 1
prostate cancer 1
BED 1
gastritis 1
biliary obstruction 1
abdominal aortic aneurysm 1
cardiovascular disease 1
denticles 1
meningitis 1
TEM 1
tumor growth 1
Cryptococcus neoformans 1
acne vulgaris 1
DMS 1
malnutrition 1
Disorder 1
AIDS 1
Dependence 1
APOA1 1
ovarian cancer 1
pheochromocytoma 1
urticaria 1
uterus 1
migraine 1
mental retardation 1
coccidiosis 1
malaria 1
cholecystolithiasis 1
PCS 1
mental retardation 1
amnesia 1
thymoma 1
dehydration 1
corneal dystrophy 1
cognitive disorder 1
skin infection 1
fatty liver 1
Advanced cancer 1
GSH 1
Autism 1
biventricular failure 1
Testis 1
neoplastic transformation 1
Huntington's disease 1
acute myeloid leukemia 1
Testis 1
brain dysfunction 1
pertussis 1
eczema 1
metabolic disorder 1
ash 1
Albert 1
lipodystrophy 1
hyperhomocysteinemia 1
myelopathy 1
HLA-B27 1
Cerebrovascular amyloidosis 1
Habituation 1
AAA 1
fits 1
Fibrillation 1
brain tumor 1
Dementia with Lewy bodies 1
amyotrophic lateral sclerosis 1
cholecystitis 1
retinitis pigmentosa 1
Sporadic cerebral amyloid angiopathy 1
more...
Symptom
memory loss 4
anesthesia 2
functional recovery 1
anorexia 1
arm pain 1
Decreased activity 1
diarrhea 1
Drug
Gel 5
CSF 4
Glucagon 4
ADM 3
Activin 3
Dermatol 3
Aprotinin 2
uPA 2
DMI 1
Apomorphine 1
Perindopril 1
Idebenone 1
Ginseng 1
Fructose 1
Donepezil 1
ALA 1
Poudre 1
CTA 1
Imatinib 1
CaCl2 1
Glutathione 1
Glycerol 1
Meth 1
DNase I 1
MTC 1
lysine 1
Asn 1
ZnCl2 1
Alanine 1
Nephron 1
Ammonium chloride 1
Liraglutide 1
ZnCl2 1
ABC 1
MAP 1
Cardiovasc 1
Lead acetate 1
Gleevec 1
ascorbate 1
Calcium chloride 1
EE2 1
FAD 1
ROS 1
Spectrum 1
Parkin 1
Parkin 1
Vitamin E 1
Urso 1
Spectrum 1
IL-2 1
DEL 1
Enzyme
insulin-degrading enzyme 737
CD10 118
proteasome 28
endothelin-converting enzyme 21
protein kinase 16
ERK 15
plasmin 13
PTR 13
mitogen-activated protein kinase 12
trypsin 8
glutathione-insulin transhydrogenase 8
beta-secretase 8
nardilysin 7
ACE 7
cathepsin D 6
cathepsin B 6
acetylcholinesterase 6
thermolysin 5
ACS 5
GSK 5
MPP 4
APC 4
protein kinase C 4
lysozyme 4
transhydrogenase 4
ATPase 4
cholinesterase 3
thimet oligopeptidase 3
urokinase-type plasminogen activator 3
furin 3
catalase 3
AMPK 3
RNase 3
RNase 3
AMP-activated protein kinase 3
chymotrypsin 3
tissue plasminogen activator 2
glucose oxidase 2
superoxide dismutase 2
neurolysin 2
MMP-3 2
caspase-3 2
lactate dehydrogenase 2
PAM 2
glutathione peroxidase 2
renin 2
cathepsin L 2
AMPK 2
TPP 2
PTPase 2
subtilisin 1
TOR 1
proteinase K 1
NADH pyrophosphatase 1
caspase-8 1
focal adhesion kinase 1
IDS3 1
beta-glucuronidase 1
phosphodiesterase 1
neuraminidase 1
aldolase 1
prostate-specific membrane antigen 1
IDS2 1
hexokinase 1
MMP 1
diaphorase 1
neuropathy target esterase 1
prostate-specific antigen 1
caspase-9 1
polysaccharide deacetylase 1
choline acetyltransferase 1
CaMKII 1
phosphatidylinositol 3-kinase 1
malate dehydrogenase 1
endoproteinase Glu-C 1
PNGase F 1
peroxidase 1
phosphoinositide 3-kinase 1
ribonuclease 1
cdc2 1
EC 3.4.24.54 1
sialidase 1
KLK7 1
matrix metalloproteinase 9 1
NADPH oxidase 1
NADPH oxidase 1
MAP 1
prolyl endopeptidase 1
alpha-amylase 1
complex I 1
apyrase 1
dihydrofolate reductase 1
phosphoglucose isomerase 1
glucokinase 1
P-glycoprotein 1
transcriptase 1
glutathione S-transferase 1
acyl-CoA oxidase 1
choline kinase 1
aminopeptidase B 1
HIV-1 protease 1
ribonuclease 1
alkaline phosphatase 1
acetyl-CoA carboxylase 1
RNA polymerase 1
inositol 3-kinase 1
citrate synthase 1
SMP 1
TPP 1
tripeptidyl peptidase 1
CPR 1
thrombin 1
fructose 1,6-bisphosphatase 1
lysyl endopeptidase 1
Compound
glucose 71
Insulin 71
Dec 55
zinc 34
water 33
tyrosine 27
ATP 22
Clin 21
leucine 20
DNA 19
TCA 19
Phe 18
serine 16
His 12
sodium 12
EDTA 11
SDS 11
TNF 11
sulfate 11
alanine 11
EDTA 11
arginine 9
calcium 9
ammonium 9
Asp 9
phosphate 8
B17 8
manganese 8
lysine 8
methionine 7
oxygen 7
iron 6
nitric oxide 6
aluminum 6
cysteine 6
acetate 6
valine 5
Bacitracin 5
copper 5
glutamate 5
ACS 5
ACS 5
threonine 5
cobalt 4
DEAE 4
NH2 4
galactose 4
salt 4
Glucagon 4
AMP 4
aspartic acid 4
COS 4
proline 4
hydrogen 3
IDA 3
chromium 3
Diabetol 3
ADP 3
Wellcome 3
Ile 3
Diabetol 3
aspartic acid 3
glutamine 3
Congo red 3
aspartic acid 3
aspartic acid 3
STZ 3
palmitic acid 3
cadmium 2
MTT 2
acetic acid 2
ADP 2
formic acid 2
Lead 2
formic acid 2
Chloroquine 2
PAM 2
mercury 2
Geniposide 2
Salt 2
guanidine 2
glycerol 2
Adenine 2
ADP 2
formic acid 2
nitrogen 2
GSH 2
acetone 2
PAM 2
Chloroquine 2
Triphosphate 2
formic acid 2
Propranolol 2
asparagine 2
formic acid 2
PAM 2
formic acid 2
potassium 2
Neuronal 2
Estrogen 2
GSH 2
Gly 2
formic acid 2
formic acid 2
silver 2
DMSO 2
Propranolol 2
formic acid 2
formic acid 2
urea 2
octanoic acid 2
cAMP 2
acrylamide 2
TPP 1
Metformin 1
CAP 1
PAC 1
vitamin D 1
anthracene 1
APH 1
isoleucine 1
Capsaicin 1
ABA 1
phosphorus 1
palmitic acid 1
DMI 1
MPP 1
Estrogen 1
DBI 1
trifluoroacetic acid 1
TPP 1
IPA 1
CCl4 1
Pyrroloquinoline quinone 1
Angiotensin II 1
ethanol 1
2-butenoic acid 1
Leupeptin 1
Testosterone 1
MDA 1
Metformin 1
Leucine 1
vanadium 1
[1,10]phenanthroline 1
Perindopril 1
adenylate 1
FAD 1
Mg2+ 1
Thiorphan 1
IPA 1
dUTP 1
Cereb 1
Adenosine 1
tryptophan 1
Memantine 1
TEM 1
tryptophan 1
CAM 1
acridine 1
HVA 1
more...