Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.56 (
insulin-degrading enzyme
)
737
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The primary structure of the rat
insulin-degrading enzyme
(
IDE
) was determined by cDNA analysis. Rat
IDE
, as well as the previously characterized homologs from human and Drosophila, contain the carboxyl-terminal consensus sequence A/S-K-L, for peroxisome targeting. A stretch of 43 bp surrounding an alternatively used polyadenylation site is highly conserved between rat and human, suggesting that it may contain important regulatory information. Northern blot analysis revealed two
IDE
transcripts of 3.7 and 5.5 kb in various tissues.
Testis
was found to be exceptional in having three different RNAs (3.7, 4.1 and 6.1 kb) at a relatively high abundance. The expression of the
IDE
gene in testis is correlated with sexual maturation.
...
PMID:The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts. 842 12
