Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:3.4.24.55 (PTR)
433 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Platelet transfusion recipients become alloimmunized to foreign HLA and HPA antigens, impairing their responses to further platelet transfusions (platelet transfusion refractoriness; PTR). Anti-HLA and HPA antibodies account for the majority of clinically significant alloimmunizations. Poor transfusion responses due to alloimmunization may be overcome by selection of HLA or HPA-compatible donors. Several approaches including use of white cell-depleted products have been shown to prevent or delay alloimmunization in transfusion recipients. This paper focused on: 1) factors involved in the development of platelet alloimmunization, 2) diagnosis of PTR and platelet alloimmunization, 3) effective management of the alloimmunization.
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PMID:[Platelet transfusion refractoriness and effective management of platelet alloimmunization]. 930 6

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