Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.4.24.35 (matrix metalloproteinase 9)
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Human Gene/Protein
VICKZ2 13.8
Nucleosome-binding protein 1 13.8
matrix metalloproteinase 9 13.8
integrin, alpha 8 13.8
Adenylyl cyclase-associated protein 12.8
GCP-1 11.8
MID1IP1 11.5
ZNT4 11.5
type I collagen alpha 1 chain 11.5
matrix metalloproteinase 2 11.4
metalloelastase 11.4
N-acetylneuraminate pyruvate lyase 11.2
ZNT6 11.2
PLGL 11.1
Metalloelastase 11.0
HuP1 11.0
heterogeneous nuclear ribonucleoprotein A3 10.8
alpha-2-macroglobulin receptor 10.8
zinc transporter 5 10.8
MMP9 10.8
tissue inhibitor of metalloproteinase 1 10.8
Matrix metalloproteinase 9 10.7
Laminin subunit beta-3 10.6
matrilysin 10.4
granulocyte chemotactic protein-2 10.4
Type XIV collagen 10.4
LYNX1 10.4
Kruppel-like factor 8 10.4
protein tyrosine phosphatase receptor type C 10.4
TIMP metallopeptidase inhibitor 1 10.2
CX3CL1 protein 10.2
GCP-2 10.2
Extracellular matrix protein 1 10.1
MPP-9 10.1
selectin P 10.1
stromelysin 10.1
ZNT7 10.1
bone marrow stromal cell antigen 1 10.0
matrix metalloproteinase 10 10.0
Chitinase-3-like protein 1 10.0
collagenase-3 10.0
normal epithelial cell-specific 1 9.9
nuclear receptor coactivator 5 9.9
stromelysin-3 9.8
BTG1 protein 9.8
Alpha-L-fucosidase 9.8
PFDN1 9.8
epilysin 9.6
paternally expressed gene 1 9.6
CNK1 9.6
PSTK 9.6
kallikrein-related peptidase 4 9.6
tissue inhibitor of metalloproteinases 9.5
KLRD1 9.5
Tissue inhibitor of metalloproteinase 1 9.4
PRS II 9.4
TIMP-2 9.4
TRAF-3 9.4
JFC1 9.4
MMP-9 9.3
matrix metalloproteinase 1 9.3
metalloproteinase 1 9.3
Supervillin 9.3
calcyphosine 9.3
MMP-3 9.3
TIMP 9.3
MMP-26 9.2
osteoclast-associated receptor 9.2
metastasis-related protein 9.2
MMP-1 9.1
RAB27B 9.1
mitogen-activated protein kinase 6 9.1
secretory leukocyte peptidase inhibitor 9.1
LCN2 protein 9.1
beta B1-crystallin 9.1
FXYD5 9.1
clone 10 9.1
RLN2 9.0
PTPE 9.0
B2t 9.0
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Disease
Corticosteroid-induced glaucoma 11.8
Cytotoxic edema 10.0
Fowl cholera 9.6
Stromal keratitis 9.6
Elastolysis 9.4
MYP3 9.4
chronic nasopharyngitis 9.4
Microinvasive 8.7
tooth resorption 8.2
Cardiac autonomic neuropathy 7.9
Lymphatic metastasis 7.9
West Nile encephalitis 7.6
cerebral degeneration 7.5
Transient cerebral ischemia 7.3
Alveolar bone loss 7.2
Pseudopregnancy 7.2
Middle cerebral artery occlusion 7.1
cough variant asthma 7.1
Malignant glioma 7.0
Fungal keratitis 6.8
Epidermolysis bullosa acquisita 6.7
Granuloma annulare 6.7
Diabetic complications 6.6
Infantile hemangioma 6.6
salivary gland cancer 6.5
Squamous Cell Carcinoma 6.5
Streptococcus pneumoniae meningitis 6.5
erythroplakia 6.5
Lyme arthritis 6.4
Breast carcinoma 6.4
metastatic osteosarcoma 6.4
Papillomas 6.3
tympanosclerosis 6.2
Acute Stroke 6.1
Renovascular hypertension 6.0
Hypertrophic 6.0
Complex regional pain syndrome 6.0
brain edema 5.9
papillary serous carcinoma 5.9
squamous cell carcinoma of the skin 5.9
PARK7 5.8
fibrosarcoma 5.7
embryonal tumor 5.7
metastatic bladder cancer 5.7
causalgia 5.6
Giant cell tumor of bone 5.6
autoimmune lymphoproliferative syndrome 5.6
Urbach 5.4
body lice 5.4
Angiostrongylus cantonensis 5.4
pancreatic fibrosis 5.4
Cerebral malaria 5.4
scleritis 5.4
cancer relapse 5.4
erythroblastosis 5.3
Bielschowsky 5.3
Granuloma 5.3
HGF 5.3
monocytic leukemia 5.3
MSS 5.3
premature rupture of membranes 5.2
infiltrating ductal carcinoma 5.2
PNET 5.2
enchondroma 5.2
pemphigoid 5.2
Renal fibrosis 5.2
renal clear cell carcinoma 5.1
plexiform neurofibroma 5.1
tumor angiogenesis 5.1
Heymann nephritis 5.1
hydrosalpinx 5.0
Osteosarcoma 5.0
Osteosarcoma 5.0
Allergic asthma 5.0
Tick-borne encephalitis 4.9
Angiosarcoma 4.9
Friend leukemia 4.8
pulmonary fibrosis 4.8
metastatic colon cancer 4.8
Deep vein thrombosis 4.8
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Symptom
Central post-stroke pain 9.0
impaired motor coordination 6.2
swollen joints 5.8
functional recovery 3.6
dry eye 3.5
hyperoxia 3.1
chronic cough 2.8
skin irritation 2.7
thinning 2.7
respiratory distress 1.9
acute stress 1.6
splenomegaly 1.5
hypothermia 1.3
spasm 1.0
dystonia 0.8
dizziness 0.6
angina 0.4
starvation 0.2
erythema 0.1
analgesia 0.0
collapse 0.0
ataxia -0.1
chest pain -0.3
anesthesia -0.3
pain -0.7
cough -0.7
overweight -0.9
seizures -0.9
abdominal pain -1.1
weakness -1.4
headache -2.0
Drug
Liarozole fumarate 11.8
Trocade 11.2
Prinomastat 9.6
Batimastat 9.3
Batimastat 9.3
Avasimibe 9.2
Ilomastat 8.6
Prolastin 8.5
Gelatin 8.5
Oxaprozin 7.9
Hyoscyamine 7.8
Fennel 7.8
Marimastat 7.6
Lacidipine 7.1
Trilostane 7.0
Lacidipine 6.8
Aliskiren 6.8
Hyperforin 6.8
Eptifibatide 6.7
ID2 6.7
uPA 6.4
Artemether 6.3
Argatroban 6.0
Magnesium sulfate 5.8
Doxycycline 5.7
Ketotifen 5.6
Urokinase 5.5
Rutin 5.5
CTT 5.1
Cilostazol 5.1
Emodin 4.9
Amiloride 4.8
Simvastatin 4.7
Emodin 4.6
BTC 4.6
Amiloride 4.6
Glide 4.5
PDL 4.5
Rosiglitazone 4.2
Methylprednisolone 4.0
Monensin 3.9
IFN-beta 3.8
Propofol 3.8
AraC 3.8
Vitamin E 3.7
Lactose 3.7
DNase I 3.6
TAT 3.6
Indomethacin 3.5
p75 3.5
Pronase 3.5
ZnCl2 3.5
ZnCl2 3.5
G-CSF 3.5
PTH 3.4
IL-1ra 3.4
Gleevec 3.3
Prednisolone 3.3
Bortezomib 3.3
Bevacizumab 3.0
NaI 3.0
NaI 3.0
NaI 3.0
NaI 3.0
Fructose 2.9
-deoxyadenosine 2.8
CaCl2 2.8
CaCl2 2.8
EPI 2.8
Gel 2.8
CaCl2 2.7
Paraffin 2.7
MDS 2.7
Captopril 2.7
Asn 2.6
CSF 2.6
Imatinib 2.5
IFN-gamma 2.5
Alliance 2.4
AZT 2.4
more...
Enzyme
matrix metalloproteinase 9 13.8
matrix metalloproteinase 2 11.9
galactose-6-sulfatase 11.5
collagenase 3 11.0
macrophage elastase 10.7
interstitial collagenase 10.7
matrix metalloproteinase 10 10.3
neutrophil collagenase 10.2
stromelysin-3 10.2
matrilysin-2 9.5
MMP-3 9.5
deuterolysin 9.3
MMP 9.1
cathepsin K 8.5
IgA protease 7.9
adamalysin 7.5
collagenase 7.5
NADPH:quinone oxidoreductase 7.5
hydroxyprostaglandin dehydrogenase 7.2
pantetheinase 7.0
cathepsin G 7.0
glycoprotease 6.9
hatching enzyme 6.8
IgA1 protease 6.7
neutrophil elastase 6.7
urokinase-type plasminogen activator 6.5
chondroitin ABC lyase 6.3
histidyl-tRNA synthetase 6.3
chymase 6.2
TACE 6.2
PIP kinase 6.2
pregnancy-associated plasma protein-A 6.1
aminopeptidase P 6.1
ancrod 6.0
plasmin 5.9
cathepsin S 5.9
isopeptidase 5.7
proline dehydrogenase 5.5
elastase 5.5
matriptase 5.3
tissue plasminogen activator 5.3
TSP-1 5.1
cathepsin B 5.0
matriptase 4.8
cathepsin D 4.8
meprin 4.7
tryptase 4.7
arylsulfatase A 4.5
thermolysin 4.5
endothelin-converting enzyme 4.5
cathepsin L 4.5
phosphatidylinositol 4-kinase 4.4
mu-calpain 4.4
type III procollagen 4.4
CD13 4.3
alanine aminopeptidase 4.3
insulin-degrading enzyme 4.3
PNGase F 4.2
MCS 4.2
TMT 4.2
m-calpain 4.1
CD10 4.1
MIP 4.1
phosphoinositide 3-kinase 4.1
acid phosphatase 4.1
12-lipoxygenase 4.1
mitogen-activated protein kinase 4.1
p100 4.0
Pla 4.0
prostaglandin synthetase 4.0
3beta-hydroxysteroid dehydrogenase 4.0
carboxypeptidase A 3.9
diacylglycerol kinase 3.9
BAL 3.9
isocitrate dehydrogenase 3.8
proprotein convertase 3.7
granzyme B 3.7
trypsin 3.7
MEK 3.7
isocitrate dehydrogenase 3.6
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Compound
C21H19NO4S 12.8
C21H19NO4S 12.8
C21H19NO4S 12.8
C21H19NO4S 12.2
C5H10N2O2 12.2
Pseurotin A 11.2
CEPC 11.0
Gossypin 10.4
Butin 10.2
Methacycline 10.1
Pectolinarigenin 10.1
27-Hydroxycholesterol 9.6
Oxaprozin 8.4
Malvidin 8.4
Collagenase 8.2
Brazilin 8.1
DT3 8.0
thiirane 7.9
Benztropine 7.8
Escin 7.6
Escin 7.5
p-Cymene 7.4
Sesamin 7.3
Esculin 7.1
TCTP 7.1
Palmitoylethanolamide 7.0
Embelin 7.0
erythrodiol 7.0
Matrine 6.9
Matrine 6.9
Matrine 6.9
Indirubin 6.9
Hyperforin 6.8
CD 3 6.7
S-methylcysteine 6.7
Coomassie Brilliant Blue G 6.7
prostaglandin J2 6.6
Palmitoleic acid 6.5
TTNPB 6.5
NEU 6.5
Fluvastatin 6.5
Phorbol-12-myristate-13-acetate 6.5
Isoliquiritigenin 6.5
Nobiletin 6.3
Ginsenoside Rg1 6.3
PGJ2 6.2
Cinnamic acid 6.2
TACE 6.2
Eplerenone 6.1
Magnolol 6.1
Tauroursodeoxycholic acid 6.1
Argatroban 6.0
Chelerythrine 6.0
Plumbagin 6.0
Chelerythrine 6.0
Formoterol 5.9
Pepstatin 5.9
Fisetin 5.8
Shikonin 5.8
Doxycycline 5.7
Magnesium sulfate 5.7
Miconazole 5.7
Leupeptin 5.7
Montelukast 5.7
Paeoniflorin 5.6
Magnesium sulfate 5.6
Edaravone 5.5
Keratin 5.5
Celastrol 5.5
Phorbol 12-myristate 13-acetate 5.4
ADMA 5.4
Phalloidin 5.4
Clotrimazole 5.4
Sevoflurane 5.3
Leupeptin 5.3
THP 5.3
DHB 5.3
THP 5.3
NMA 5.3
HEI 5.3
more...