Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Traumatic brain injury (TBI) causes multiple long-term defects including a loss of working memory that is frequently incapacitating. Administrations of mesenchymal stem/stromal cells (MSCs) previously produced beneficial effects in models of TBI as well as other disease models. In several models, the beneficial effects were explained by the MSCs being activated to express
TSG-6
, a multifunctional protein that modulates inflammation. In a mouse model of TBI, we found the initial mild phase of the inflammatory response persisted for at least 24h and was followed by secondary severe response that peaked at 3days. Intravenous human MSCs or
TSG-6
during initial mild phase decreased neutrophil extravasation, expression of
matrix metalloproteinase 9
by endothelial cells and neutrophils, and the subsequent blood brain barrier leakage in secondary phase. Administration of
TSG-6
also decreased the lesion size at 2weeks. Importantly, the acute administration of
TSG-6
within 24h of TBI was followed 6 to 10weeks later by improvements in memory, depressive-like behavior and the number of newly born-neurons. The data suggested that acute administration of
TSG-6
may be an effective therapy for decreasing some of the long-term consequences of TBI.
...
PMID:Administration of TSG-6 improves memory after traumatic brain injury in mice. 2385 8
