Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.4.24.35 (
matrix metalloproteinase 9
)
2,207
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cataract is a common cause of blindness and results from destruction of the microarchitecture of the lens. It is observed in many genetic syndromes, infections, inflammatory diseases and during aging. Fluctuations in lens density and light scattering by altered refraction index form the physical basis for this process, but the pathogenesis is poorly understood. Increased levels of
gelatinase B
/matrix metalloproteinase-9 have been reported for cataract-associated disorders such as eye inflammation and diabetes. We demonstrate that incubation of lenses with
gelatinase B
leads immediately to cataract. In complete eye extracts,
betaB1 crystallin
was identified as the major
gelatinase B
substrate by combination of proteomics, mass spectrometry, and Edman degradation analysis. The cleavage of
betaB1 crystallin
was also observed in vivo after endogenous
gelatinase B
-induction by the chemokine granulocyte chemotactic protein-2 in wild-type mice but not in
gelatinase B
-/- mice.
...
PMID:Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin. 1562 92
